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Table 2 Clinical outcomes within the 28 days after inclusion

From: Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort study

  Total population (n = 191) Responders (n = 96) Non-responders (n = 95) P
PaO2/FiO2 response to prone positioning (%, mmHg) 49 [19–100] 100 [67–155] 19 [3–31]  < 0.001
Duration of prone positioning (hours) 16 [16–17] 16 [16–16.7] 16 [16–17] 0.757
Tracheostomy—no (%) 113 (59.2) 46 (47.9) 67 (70.5) 0.008
Duration of MV, days 18 [11–28] 18 [10–27] 18 [12–29] 0.432
Attempted extubation—no (%) 39 (20.4) 33 (34.3) 6 (6.3)  < 0.001
Weaning failure—reintubation no (%) 22 (18.8) 17 (17.7) 5 (5.3) 0.093
VAP—no (%) 105 (55) 53 (55.2) 52 (54.7) 0.885
Steroid use 133 (70%) 72 (75%) 61 (64%) 0.083
Non pulmonary infections—no (%) 72 (37.7) 37 (38.5) 35 (36.8) 0.882
Cardiovascular complications—no (%) 31 (16.2) 13 (13.5) 18 (18.9) 0.333
Digestive complications—no (%) 8 (4.2) 5 (5.2) 3 (3.2) 0.721
Neurologic complications—no (%) 17 (8.9) 9 (9.4) 8 (8.4) 1.000
Renal Replacement therapy—no (%) 43 (22.5) 22 (22.9) 21 (22.1) 1.000
Veno-venous ECMO—no (%) 3 (1.6) 0 (0.0) 3 (3.2) 0.121
ICU length of stay, days 22 [14–35] 22[15–35] 21[14–35] 0.994
VFD at 28 days, days 4.5 ± 7.1 6.3 ± 8.1 2.7 ± 5.6  < 0.001
ICU mortality—no (%) 83 (43.4) 32 (33.3) 51 (53.7) 0.006
  1. Values are median (IQR) except for VFD (Mean ± SD). Significant P values are highlighted in bold
  2. FiO2  inspired fraction of oxygen, CRS  respiratory system compliance measured in supine position, PaO2  arterial oxygen partial pressure, MV  mechanical ventilation, NIV  non-invasive ventilation, CPAP  continuous positive airway pressure, HFNO  high flow nasal oxygen, VFD  ventilator free days, VAP  ventilator associated pneumonia, DP  driving pressure