Skip to main content

Table 2 Clinical outcomes within the 28 days after inclusion

From: Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort study

 

Total population (n = 191)

Responders (n = 96)

Non-responders (n = 95)

P

PaO2/FiO2 response to prone positioning (%, mmHg)

49 [19–100]

100 [67–155]

19 [3–31]

 < 0.001

Duration of prone positioning (hours)

16 [16–17]

16 [16–16.7]

16 [16–17]

0.757

Tracheostomy—no (%)

113 (59.2)

46 (47.9)

67 (70.5)

0.008

Duration of MV, days

18 [11–28]

18 [10–27]

18 [12–29]

0.432

Attempted extubation—no (%)

39 (20.4)

33 (34.3)

6 (6.3)

 < 0.001

Weaning failure—reintubation no (%)

22 (18.8)

17 (17.7)

5 (5.3)

0.093

VAP—no (%)

105 (55)

53 (55.2)

52 (54.7)

0.885

Steroid use

133 (70%)

72 (75%)

61 (64%)

0.083

Non pulmonary infections—no (%)

72 (37.7)

37 (38.5)

35 (36.8)

0.882

Cardiovascular complications—no (%)

31 (16.2)

13 (13.5)

18 (18.9)

0.333

Digestive complications—no (%)

8 (4.2)

5 (5.2)

3 (3.2)

0.721

Neurologic complications—no (%)

17 (8.9)

9 (9.4)

8 (8.4)

1.000

Renal Replacement therapy—no (%)

43 (22.5)

22 (22.9)

21 (22.1)

1.000

Veno-venous ECMO—no (%)

3 (1.6)

0 (0.0)

3 (3.2)

0.121

ICU length of stay, days

22 [14–35]

22[15–35]

21[14–35]

0.994

VFD at 28 days, days

4.5 ± 7.1

6.3 ± 8.1

2.7 ± 5.6

 < 0.001

ICU mortality—no (%)

83 (43.4)

32 (33.3)

51 (53.7)

0.006

  1. Values are median (IQR) except for VFD (Mean ± SD). Significant P values are highlighted in bold
  2. FiO2  inspired fraction of oxygen, CRS  respiratory system compliance measured in supine position, PaO2  arterial oxygen partial pressure, MV  mechanical ventilation, NIV  non-invasive ventilation, CPAP  continuous positive airway pressure, HFNO  high flow nasal oxygen, VFD  ventilator free days, VAP  ventilator associated pneumonia, DP  driving pressure