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Table 1 Reported use of ECMO in recent ARDS studies

From: A rational approach on the use of extracorporeal membrane oxygenation in severe hypoxemia: advanced technology is not a panacea

Study

Intervention

Population

Total patients

N

Total ECMO use

n (% of N)

ECMO use in intervention group

n (% of N)

ACURASYS [95]

Cisatracurium

Severe ARDS (PF ratio < 150 mmHg)

339

0 (0)

0 (0)

ART [120]

Lung recruitment maneuvers

Moderate-to-severe ARDS (PF ratio ≤ 200 mmHg)

1010

10 (0.99)

5 (0.5)

EPVENT-2 [121]

Transpulmonary pressure targets

Moderate-to-severe ARDS (PF ratio ≤ 200 mmHg)

200

4 (2.0)

1 (0.5)

ICU-ROX [122]

Conservative oxygen

PF ratio < 300 mmHg

623

13a (2.09)

7a (1.12)

LIVE [123]

Personalized mechanical ventilation

Moderate-to-severe ARDS (PF ratio ≤ 200 mmHg)

400

14 (3.5)

7 (1.75)

LOCO2 [124]

Liberal oxygen

Mild-to-severe ARDS (PF ratio ≤ 300 mmHg)

201

0 (0)

0 (0)

LUNG SAFE [73]

NA

Mild-to-severe ARDS (PF ratio ≤ 300 mmHg)

2377

76 (3.2)

N/A

PHARLAP [125]

Lung recruitment maneuvers

Moderate-to-severe ARDS (PF ratio ≤ 200 mmHg)

114

7 (6.14)

1 (0.88)

PROSEVA [68]

Prone positioning

Severe ARDS (PF < 150 mmHg)

466

8 (1.72)

2 (0.43)

ROSE [69]

Cisatracurium

Moderate-to-severe ARDS (PF ≤ 200 mmHg)

1006

13 (1.29)

3 (0.30)

Total

  

6736

145 (2.15)

 
  1. aThe number of patients reported (N) reflects the use of extracorporeal membrane oxygenation (ECMO) and extracorporeal carbon dioxide removal (ECCO2R). NA non-applicable; ARDS, acute respiratory distress syndrome; PF,  ratio of partial pressure of oxygen to inspired fraction of oxygen