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Table 2 Univariable and multivariable analysis: factors associated with 30-day mortality

From: Outcome of cancer patients considered for intensive care unit admission in two university hospitals in the Netherlands: the danger of delayed ICU admissions and off-hour triage decisions

 

30-day

Mortality

Univariable analysis

Multivariable analysis

Odds ratio

95% CI

p-value

Odds ratio

95% CI

p-value

Age

1.02

1.01–1.03

0.001*

1.04

1.02–1.05

 < 0.001*

Male

192 (38.5%)

1.08

0.80–1.46

0.61

   

Solid malignancy (ref)

176 (35%)

      

Hematological malignancy

117 (42.7%)

1.39

1.02–1.87

0.03*

1.63

1.02–2.60

0.04*

Metastatic disease

101 (41.2%)

1.23

0.91–1.68

0.19

1.05

0.56–1.96

0.89

Cancer recurrence

32 (45.1%)

1.39

0.85–2.27

0.19

1.39

0.74–2.60

0.31

Controlled cancer (ref)

98 (26.4%)

      

Uncontrolled cancer

197 (48.3%)

2.60

1.92–3.52

 < 0.001*

2.30

1.54–3.41

 < 0.001*

CCI

1.08

1.01–1.15

0.02*

1.02

0.89–1.15

0.82

ECOG PS before hospital admission

 0 (ref)

47 (26%)

      

 1

107 (35.9%)

1.60

1.06–2.40

0.02*

1.33

0.81–2.18

0.27

 2

82 (42.9%)

2.15

1.38–3.33

0.001*

1.84

1.07–3.19

0.03*

 3

44 (48.9%)

2.73

1.61–4.64

 < 0.001*

2.40

1.21–4.77

0.01*

 4

13 (86.7%)

18.53

4.03–85.19

 < 0.001*

12.42

2.34–65.93

0.003*

MEWS

 

1.13

1.05–1.20

 < 0.001*

1.13

1.04–1.23

0.006*

Cancer treatment

252 (36.8%)

0.77

0.50–1.20

0.25

   

Immunocompromised

214 (38.2%)

1.09

0.79–1.51

0.61

   

ICU triage decision

 ICU admission (ref)

141 (36.9%)

      

 Too well to benefit—no ICU admission

66 (25.6%)

0.59

0.42–0.83

0.003*

0.66

0.42–1.04

0.08

 Too well to benefit—delayed ICU

34 (45.9%)

1.45

0.88—2.40

0.15

1.83

1.00—3.33

0.048*

 Too sick to benefit

54 (81.8%)

7.69

3.98–14.87

 < 0.001*

7.78

3.38–17.89

 < 0.001*

Year ICU consult

 2016 (ref)

78 (36.4%)

   

 2017

77 (37.7%)

1.06

0.71–1.57

0.78

   

 2018

87 (39.2%)

1.12

0.76–1.66

0.56

   

 2019

53 (37.9%)

1.06

0.68–1.65

0.79

   

Earlier ICU admission before consult

18 (23.4%)

0.47

0.27–0.81

0.007*

0.82

0.41–1.64

0.57

One ICU physician (ref)

109 (34.3%)

      

Two ICU physicians

155 (40.3%)

1.29

0.95–1.76

0.10

0.97

0.64–1.46

0.87

More than two ICU physicians

31 (40.3%)

1.29

0.78–2.15

0.33

0.95

0.48–1.87

0.88

One referring physician (ref)

53 (32.3%)

      

Two referring physicians

195 (39.3%)

1.36

0.93–1.97

0.11

1.27

0.80–2.03

0.31

More than two referring physicians

45 (39.8%)

1.39

0.84–2.28

0.20

1.24

0.64–2.38

0.53

Location consult

 Emergency room (ref)

57 (41.6%)

   

 Ward

188 (38.9%)

0.89

0.61–1.32

0.57

1.42

0.86–2.35

0.18

 Other

50 (31.3%)

0.64

0.40–1.03

0.07

1.70

0.90–3.20

0.10

On-hours (ref)

103 (32.7%)

      

Off-hours

192 (41.3%)

1.45

1.07–1.95

0.02*

1.61

1.09–2.38

0.02*

Weekend

95 (38.9%)

1.07

0.79–1.46

0.67

   

Consult reason

 Shock

68 (45.3%)

2.49

1.48–4.19

0.001*

1.78

0.97–3.26

0.06

 Respiratory insufficiency

188 (38.9%)

1.48

1.02–2.17

0.04*

1.18

0.77–1.83

0.45

 Altered consciousness

68 (48.9%)

2.12

1.35–3.34

0.001*

1.73

1.06–2.83

0.03*

 Sepsis

87 (40.7%)

1.28

0.84–1.97

0.25

   

 Acute kidney injury

50 (53.2%)

2.70

1.65–4.41

 < 0.001*

2.47

1.41–4.34

0.002*

 High MEWS

10 (43.5%)

1.93

0.80–4.64

0.14

2.00

0.70–5.72

0.20

 Hemodynamic instability

102 (36.4%)

0.69

0.42–1.14

0.15

0.70

0.42–1.18

0.18

 Other

34 (35.4%)

1.14

0.70–1.87

0.59

   
  1. Table shows data of first ICU triage decision of the hospital admission
  2. A p-value of < 0.05 is considered significant (marked by an *)
  3. CCI Charlson Comorbidity Index, ECOG PS Eastern Cooperative Oncology Group Performance Status, MEWS Modified Early Warning Score, On-hours during dayshift