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Annals of Intensive Care

Table 1 Main endothelial SASP components

From: Long-term cardiovascular complications following sepsis: is senescence the missing link?

Main endothelial SASP components

Pro-inflammatory mediators

TNF-α, TGF-β, IL-1, IL-6, CSFs

Pro-inflammatory chemokines

CXCL-1, CXCL-8, CCL-2

Proteases and mediators of tissue remodeling

MMPs, PAI-1

Growth factors

VEGF, EGF, IGFBPs

  1. TNF-α tumor necrosis factor alpha, TGF-β transforming growth factor beta, IL-1 interleukin-1, IL-6 interleukin-6, CSFs colony-stimulating factor, CXCL-1 chemokine (C-X-C motif) ligand-1, CXCL-8 chemokine (C-X-C motif) ligand-8, CCL-2 C-C motif chemokine ligand 2, MMPs matrix metalloproteinases, PAI-1 plasminogen activator inhibitor-1, VEGF vascular endothelial growth factor, EGF epidermal growth factor, IGFBPs insulin-like growth factor-binding protein
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