The effect of the volemic and cardiac status on brain oxygenation in patients with subarachnoid hemorrhage: a bi-center cohort study

Annals of Intensive Care

Table 2 Changes of variables pre-, during, and post-fluid administration in a total of 198 infusions in 48 patients

Variable	Pre infusion	During infusion	Post infusion	p-value**
P_btO₂, mmHg	26 ± 10	26 ± 11	26 ± 10	0.885
BTH, percent	49 (25)	50 (25)	41 (21)	0.241
CI, L/min/m²	3.9 ± 1.1	3.9 ± 1.1	4.0 ± 1.2	< 0.001
SVV, percent	11 ± 6	11 ± 6	9 ± 5	< 0.001
MAP, mmHg	104 ± 15	104 ± 17	106 ± 16	0.116
CPP^a, mmHg				0.264
IBK	73 ± 9	71 ± 10	74 ± 10
BRU	109 ± 26	108 ± 28	109 ± 29
ICP, mmHg	12 ± 8	12 ± 9	12 ± 10	0.582
HR, bpm	86 ± 15	86 ± 15	86 ± 17	0.973
PRx^b	0.10 ± 0.28	0.08 ± 0.27	0.08 ± 0.30	0.187
Impaired autoregulation (PRx ≥ 0.2)^b	21 (42)	20 (36)	19 (34)	0.264

P_btO₂ brain tissue oxygenation, BTH brain tissue hypoxia, CI continuous cardiac index, SVV stroke volume variation, MAP mean arterial pressure, CPP cerebral perfusion pressure, ICP intracerebral pressure, HR heart rate, PRx pressure reactivity index
^aIBK: zeroed at the level of the Monroe foramen, BRU: zeroed at the heart level
Data are given in mean ± SD or counts (%)
^bSubanalysis in 15 patients
^**p-values indicate the difference between pre (1 h before) and post (1 h after) fluid administration