Table 2 Changes in characteristics and outcomes of ICU admissions between 2007 and 2018
Characteristics | 2007–2008 | 2009–2010 | 2011–2012 | 2013–2014 | 2015–2016 | 2017–2018 | p |
|---|---|---|---|---|---|---|---|
(n = 181) | (n = 230) | (n = 241) | (n = 263) | (n = 291) | (n = 319) | ||
Features at ICU admission | |||||||
Time between hospital and ICU admissions (days) | 0 [0–4] | 0 [0–3] | 0 [0–3] | 0 [0–2] | 0 [0–3] | 0 [0–4] | 0.625 |
SOFA score (points) | 5 [4–9] | 5 [4–8] | 5 [4–8] | 5 [4–8] | 5 [4–7.50] | 5 [4–9] | 0.11 |
Leukopenia | 4 (2.2) | 9 (3.9) | 15 (6.2) | 13 (4.9) | 15 (5.2) | 17 (5.3) | 0.05 |
Distribution of acute complications | |||||||
Non-specific | 113 (62.4) | 147 (63.9) | 147 (61.0) | 174 (66.2) | 179 (61.5) | 193 (60.5) | 0.56 |
Infection | 58 (32.0) | 66 (28.7) | 75 (31.1) | 91 (34.6) | 104 (35.7) | 98 (30.7) | |
Bleeding | 6 (3.3) | 10 (4.3) | 9 (3.7) | 17 (6.5) | 18 (6.2) | 19 (6.0) | |
Ischaemic events | 3 (1.7) | 2 (0.9) | 2 (0.8) | 1 (0.4) | 4 (1.4) | 3 (0.9) | |
Venous thrombo-embolism | 4 (2.2) | 8 (3.5) | 7 (2.9) | 9 (3.4) | 6 (2.1) | 11 (3.4) | |
Miscellaneous | 40 (22.1) | 61 (26.5) | 54 (22.4) | 56 (21.3) | 47 (16.2) | 62 (19.4) | |
Specific | 52 (28.7) | 62 (27.0) | 71 (29.5) | 65 (24.7) | 84 (28.9) | 75 (23.5) | 0.26 |
Metabolic | 3 (1.7) | 9 (3.9) | 9 (3.7) | 7 (2.7) | 8 (2.7) | 5 (1.6) | |
Respiratory | 20 (11.0) | 9 (3.9) | 9 (3.7) | 15 (5.7) | 6 (2.1) | 10 (3.1) | |
Urinary tract obstruction | 13 (7.2) | 8 (3.5) | 12 (5.0) | 6 (2.3) | 12 (4.1) | 3 (0.9) | |
Haematologic | 0 (0.0) | 2 (0.9) | 0 (0.0) | 0 (0.0) | 2 (0.7) | 0 (0.0) | |
Others | 16 (8.8) | 34 (14.8) | 41 (17.0) | 37 (14.1) | 58 (19.9) | 57 (17.9) | |
Adverse events | 16 (8.8) | 21 (9.1) | 23 (9.5) | 24 (9.1) | 28 (9.6) | 51 (16.0) | 0.01 |
Drug-related adverse events | 5 (2.8) | 7 (3.0) | 5 (2.1) | 10 (3.8) | 16 (5.5) | 14 (4.4) | |
Procedural adverse events | 11 (6.1) | 14 (6.1) | 18 (7.5) | 14 (5.3) | 12 (4.1) | 37 (11.6) | |
Management during the ICU stay | |||||||
Organ failure supports | |||||||
Invasive mechanical ventilation | 80 (44.2) | 100 (43.5) | 99 (41.1) | 101 (38.4) | 113 (38.8) | 135 (42.3) | 0.415 |
Non-invasive mechanical ventilation | 29 (16.0) | 20 (8.7) | 21 (8.7) | 28 (10.6) | 23 (7.9) | 42 (13.2) | 0.72 |
Vasopressors/inotropes | 74 (40.9) | 79 (34.3) | 81 (33.6) | 75 (28.5) | 96 (33.0) | 107 (33.5) | 0.14 |
Renal replacement therapy | 48 (26.5) | 44 (19.1) | 43 (17.8) | 39 (14.8) | 50 (17.2) | 35 (11.0) | < 0.001 |
Length of stay in the ICU (days) | 3 [1–8] | 3 [1–6] | 2 [1–6] | 2 [1–4] | 3 [1–5] | 3 [1–6] | 0.91 |
Decision to forgo life-sustaining therapy | 49 (27.1) | 62 (27.0) | 51 (21.2) | 70 (26.6) | 85 (29.2) | 113 (35.4) | 0.008 |
Outcomes | |||||||
ICU survival | 126 (69.6) | 176 (76.5) | 203 (84.2) | 203 (77.2) | 232 (79.7) | 240 (75.2) | 0.407 |
Hospital survivala | 83/168 (49.4) | 112/203 (55.2) | 136/224 (60.7) | 151/250 (60.4) | 176/281 (62.6) | 166/298 (55.7) | 0.75 |
One-year survivalb | 44/146 (30.1) | 60/183 (32.8) | 70/202 (34.7) | 77/223 (34.5) | 88/255 (34.5) | 85/270 (31.5) | 0.68 |