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Table 2 Pre- and on-ECMO characteristics, adverse events during the ECMO course, and outcomes

From: Role of extracorporeal membrane oxygenation in pediatric cancer patients: a systematic review and meta-analysis of observational studies

Study Days of mechanical ventilation prior to ECMO Mean (SD) or median (IQR) PaOs:FiO2 before start of ECMO Mean (SD) or median (IQR) OI before start ECMO Days on ECMO Mean (SD) or median (IQR) Type of cannulation, n (%) Mortality, n (%) Adverse events, n (%)
VV VA VV → VA VA → VVV other During ECMO run Hospital Major haemorrhage Mechanical Infections Central nervous system Renal
Lindén et al. 1999 [19] 5.0 (1.0–9.8) 56.5 (41.8–75.8) NR 17.5 (9.5–36.8) 4 (100%)      1/4 (25%) 1/4 (25%) 0 1 (25%) 1 (25%) 0 0
Gupta et al. 2008 [20] NS NS NR NR NR      NR 44/60 (73%) NR NR NR NR NR
Gow et al. 2009 [21] 2.7 (0.9–5.3) 53.0 (42.0–62.0) 52.0 (39.3–70.0) 6.1 (2.8–12.3) 28 (26.2%) 67 (62.6%) 9 (8.4%) 1 (0.9%) 2 (1.9%) 62/107 (58%) 70/107 (65.4%) 44 (41.1%) 46 (43.0%) 40 (37.3%) 28 (26.1%) 67 (62.6%)
Meister et al. 2009 [22] NR NR NR 14.0 (3.5) 3 (75%) 1 (25%)     2/4 (50%) 2/4 (50%) 1 (25%) 0 0 0 0
Di Nardo et al. 2014 [23] 2.7 (range 1.7–7.4) NR NR 7.7 (3.8–15.6) 8 17 3    14/15 (93%) 14/15 (93%) NR NR NR NR NR
Smith et al. 2016 [24] 0.3 (0.1–1) NR 19 (9.5–44.5) 5.0 (3.9–6.7)) 1 (12%) 8 (88%)     5/9 (66%) 5/9 (66%) 5 (55%)   2 (22%) 1 (11%) 6 (67%)
Bailly et al. 2017 [25] NR NR NR NR NR      NR 101/161 (62.7%) NR NR NR NR NR
Cortina et al. 2018 [26] 3 (range 0.4–14) 47 (range 32–67) NR 14 (range 2–24) 7 (77.8%) 2 (22.2%)     4/9 (44.4%) 5/9 (56%) 4 (44.4%)     3 (33.3%)
Maue et al. 2019 [27] NS NR NS NS 2 (40%) 3 (60%)     4/5 (80%) 5/5 (100%) NS   0   NS
Steppan et al. 2020 [28] NR NR NS NS NS      NS 6/16 (37.5%)     NS NS
Ranta et al. 2020 [29] 4.5 (2.0–8.0) NR NR 15 (range 1–72) 4 (33.3%) 4 (33.3%) 1 (8.3%) 1 (8.3%) 2 (16.7%) 4/12 (33.3%) 6/12 (50%) 4 (33.3%)    2 (16.7%)  
Coleman et al. 2020 [30] NR NR NR 5 (1–15; leukaemia); 2 (0–6; lymphoma); 2 (0–11; other) NR      NR 126/200 (63%) NR NR NR NR NR
Friedman et al. 2020 [31] NR NR NR NR NR      13/23 (57%) NR NR NR NR NR NR
  1. ECMO extracorporeal membrane oxygenation, IQR interquartile range, NR not reported, NS not specified for oncology patients, PICU pediatric intensive care unit, SD standard deviation, VA venoarterial, VV venovenous, VV → VA VV converted to VA, VA → VV VA converted to VV