Role of extracorporeal membrane oxygenation in pediatric cancer patients: a systematic review and meta-analysis of observational studies

Slooff, Valerie; Hoogendoorn, Rianne; Nielsen, Jeppe Sylvest Angaard; Pappachan, John; Amigoni, Angela; Caramelli, Fabio; Aziz, Omer; Wildschut, Enno; Verbruggen, Sascha; Crazzolara, Roman; Dohna-Schwake, Christian; Potratz, Jenny; Willems, Jef; Llevadias, Judit; Moscatelli, Andrea; Montaguti, Alessia; Bottari, Gabriella; Di Nardo, Matteo; Schlapbach, Luregn; Wösten-van Asperen, Roelie

doi:10.1186/s13613-022-00983-0

Annals of Intensive Care

Table 2 Pre- and on-ECMO characteristics, adverse events during the ECMO course, and outcomes

From: Role of extracorporeal membrane oxygenation in pediatric cancer patients: a systematic review and meta-analysis of observational studies

Study	Days of mechanical ventilation prior to ECMO Mean (SD) or median (IQR)	PaO_s:FiO₂ before start of ECMO Mean (SD) or median (IQR)	OI before start ECMO	Days on ECMO Mean (SD) or median (IQR)	Type of cannulation, n (%)					Mortality, n (%)		Adverse events, n (%)
Study		PaO_s:FiO₂ before start of ECMO Mean (SD) or median (IQR)	OI before start ECMO	Days on ECMO Mean (SD) or median (IQR)	VV	VA	VV → VA	VA → VVV	other	During ECMO run	Hospital	Major haemorrhage	Mechanical	Infections	Central nervous system	Renal
Lindén et al. 1999 [19]	5.0 (1.0–9.8)	56.5 (41.8–75.8)	NR	17.5 (9.5–36.8)	4 (100%)					1/4 (25%)	1/4 (25%)	0	1 (25%)	1 (25%)	0	0
Gupta et al. 2008 [20]	NS	NS	NR	NR	NR					NR	44/60 (73%)	NR	NR	NR	NR	NR
Gow et al. 2009 [21]	2.7 (0.9–5.3)	53.0 (42.0–62.0)	52.0 (39.3–70.0)	6.1 (2.8–12.3)	28 (26.2%)	67 (62.6%)	9 (8.4%)	1 (0.9%)	2 (1.9%)	62/107 (58%)	70/107 (65.4%)	44 (41.1%)	46 (43.0%)	40 (37.3%)	28 (26.1%)	67 (62.6%)
Meister et al. 2009 [22]	NR	NR	NR	14.0 (3.5)	3 (75%)	1 (25%)				2/4 (50%)	2/4 (50%)	1 (25%)	0	0	0	0
Di Nardo et al. 2014 [23]	2.7 (range 1.7–7.4)	NR	NR	7.7 (3.8–15.6)	8	17	3			14/15 (93%)	14/15 (93%)	NR	NR	NR	NR	NR
Smith et al. 2016 [24]	0.3 (0.1–1)	NR	19 (9.5–44.5)	5.0 (3.9–6.7))	1 (12%)	8 (88%)				5/9 (66%)	5/9 (66%)	5 (55%)		2 (22%)	1 (11%)	6 (67%)
Bailly et al. 2017 [25]	NR	NR	NR	NR	NR					NR	101/161 (62.7%)	NR	NR	NR	NR	NR
Cortina et al. 2018 [26]	3 (range 0.4–14)	47 (range 32–67)	NR	14 (range 2–24)	7 (77.8%)	2 (22.2%)				4/9 (44.4%)	5/9 (56%)	4 (44.4%)				3 (33.3%)
Maue et al. 2019 [27]	NS	NR	NS	NS	2 (40%)	3 (60%)				4/5 (80%)	5/5 (100%)	NS		0		NS
Steppan et al. 2020 [28]	NR	NR	NS	NS	NS					NS	6/16 (37.5%)				NS	NS
Ranta et al. 2020 [29]	4.5 (2.0–8.0)	NR	NR	15 (range 1–72)	4 (33.3%)	4 (33.3%)	1 (8.3%)	1 (8.3%)	2 (16.7%)	4/12 (33.3%)	6/12 (50%)	4 (33.3%)			2 (16.7%)
Coleman et al. 2020 [30]	NR	NR	NR	5 (1–15; leukaemia); 2 (0–6; lymphoma); 2 (0–11; other)	NR					NR	126/200 (63%)	NR	NR	NR	NR	NR
Friedman et al. 2020 [31]	NR	NR	NR	NR	NR					13/23 (57%)	NR	NR	NR	NR	NR	NR

ECMO extracorporeal membrane oxygenation, IQR interquartile range, NR not reported, NS not specified for oncology patients, PICU pediatric intensive care unit, SD standard deviation, VA venoarterial, VV venovenous, VV → VA VV converted to VA, VA → VV VA converted to VV

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