The influence of timing of coronary angiography on acute kidney injury in out-of-hospital cardiac arrest patients: a retrospective cohort study

Annals of Intensive Care

Table 4 Univariable and multivariable analysis on predictors of acute kidney injury

Predictors and covariates	Univariable analysis		Multivariable analysis*
Predictors and covariates	Odds ratio (95% CI)	p-value	Odds ratio (95% CI)	p-value
Early coronary angiography	0.71 (0.58–0.88)	0.002
Sex (reference = female)	1.07 (0.85–1.35)	0.57
Age (per year)	1.01 (1.00–1.02)	0.03
Diabetes mellitus	1.36 (1.03–1.78)	0.03
Hypertension	0.96 (0.77–1.21)	0.74
Arrest witnessed	1.35 (0.95–1.94)	0.10
Time from arrest to BLS (per minute)	1.07 (1.03–1.11)	< 0.001
Time from arrest to ROSC (per minute)	1.03 (1.02–1.04)	< 0.001	1.12 (1.06–1.19)	< 0.001
Targeted temperature management	1.92 (1.28–2.88)	0.002
Use of ACE-inhibitor or ARB	1.97 (1.43–2.70)	< 0.001	0.20 (0.04–0.91)	0.04
Heart failure (LVEF < 45%)	1.57 (1.09–2.26)	0.02
Hypotension > 30 min	3.19 (2.43–4.18)	< 0.001
Contrast used (per 10 mL)	1.05 (1.03–1.08)	< 0.001
Creatinine at baseline (per 1 pnt)	1.01 (1.01–1.01)	< 0.001	1.05 (1.03–1.07)	< 0.001
Use of IABP	1.06 (0.69–1.64)	0.80
First rhythm (reference = VF/VT)
PEA	2.38 (1.29–4.42)	0.01
Asystole	2.82 (1.87–4.25)	< 0.001
Glasgow Coma Scale < 8	3.27 (1.63–6.54)	0.001

This figure shows the independent predictors of acute kidney injury in patients successfully resuscitated of out-of-hospital cardiac arrest. Time to return of spontaneous circulation and creatinine at baseline were independent predictors for the presence of acute kidney injury
ACE-inhibitor angiotensin-converting enzyme, ARB angiotensin II receptor blocker, BLS basic life support, IABP intra-aortic balloon pump, LVEF left ventricular ejection fraction, PEA pulseless electrical activity, ROSC return of spontaneous circulation, VF ventricular fibrillation, VT ventricular tachycardia
*If p-value of univariable analysis was < 0.1, variables were entered in a backward multivariable analysis