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Table 4 Univariable and multivariable analysis on predictors of acute kidney injury

From: The influence of timing of coronary angiography on acute kidney injury in out-of-hospital cardiac arrest patients: a retrospective cohort study

Predictors and covariates Univariable analysis Multivariable analysis*
Odds ratio (95% CI) p-value Odds ratio (95% CI) p-value
Early coronary angiography 0.71 (0.58–0.88) 0.002   
Sex (reference = female) 1.07 (0.85–1.35) 0.57   
Age (per year) 1.01 (1.00–1.02) 0.03   
Diabetes mellitus 1.36 (1.03–1.78) 0.03   
Hypertension 0.96 (0.77–1.21) 0.74   
Arrest witnessed 1.35 (0.95–1.94) 0.10   
Time from arrest to BLS (per minute) 1.07 (1.03–1.11) < 0.001   
Time from arrest to ROSC (per minute) 1.03 (1.02–1.04) < 0.001 1.12 (1.06–1.19) < 0.001
Targeted temperature management 1.92 (1.28–2.88) 0.002   
Use of ACE-inhibitor or ARB 1.97 (1.43–2.70) < 0.001 0.20 (0.04–0.91) 0.04
Heart failure (LVEF < 45%) 1.57 (1.09–2.26) 0.02   
Hypotension > 30 min 3.19 (2.43–4.18) < 0.001   
Contrast used (per 10 mL) 1.05 (1.03–1.08) < 0.001   
Creatinine at baseline (per 1 pnt) 1.01 (1.01–1.01) < 0.001 1.05 (1.03–1.07) < 0.001
Use of IABP 1.06 (0.69–1.64) 0.80   
First rhythm (reference = VF/VT)
 PEA 2.38 (1.29–4.42) 0.01   
 Asystole 2.82 (1.87–4.25) < 0.001   
Glasgow Coma Scale < 8 3.27 (1.63–6.54) 0.001   
  1. This figure shows the independent predictors of acute kidney injury in patients successfully resuscitated of out-of-hospital cardiac arrest. Time to return of spontaneous circulation and creatinine at baseline were independent predictors for the presence of acute kidney injury
  2. ACE-inhibitor angiotensin-converting enzyme, ARB angiotensin II receptor blocker, BLS basic life support, IABP intra-aortic balloon pump, LVEF left ventricular ejection fraction, PEA pulseless electrical activity, ROSC return of spontaneous circulation, VF ventricular fibrillation, VT ventricular tachycardia
  3. *If p-value of univariable analysis was < 0.1, variables were entered in a backward multivariable analysis