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Annals of Intensive Care

Table 2 Baseline characteristics between AKI patients with and without renal recovery in the derivation cohort

From: Cell cycle arrest biomarkers for predicting renal recovery from acute kidney injury: a prospective validation study

Variables

Recovery (n = 115)

Non-recovery (n = 79)

p value

Baseline characteristics

 Age (year)

62 (49, 76)

62 (50, 71)

0.483

 Female gender

71 (61.7)

46 (58.2)

0.656

 BMI (kg/m2)

23.3 (20.5, 24.8)

22.6 (19.5, 23.9)

0.354

 APACHE II score

14.0 (12.0, 16.0)

16.0 (14.0, 18.0)

 < 0.001

 Nonrenal SOFA score

4 (1, 6)

6 (3, 9)

 < 0.001

Admission type

 Medical

18 (15.6)

12 (15.2)

0.887

 Surgical (abdominal surgery)

51 (44.3)

42 (53.2)

0.213

 Surgical (non-abdominal surgery)

38 (33.0)

17 (21.5)

0.189

 Emergency

8 (7.0)

8 (10.1)

0.536

Comorbidities

 COPD/asthma

9 (7.8)

11 (13.9)

0.229

 Cardiovascular disease

26 (22.6)

14 (17.7)

0.472

 Chronic liver disease

26 (22.6)

16 (20.3)

0.726

 Diabetes

28 (24.3)

21 (26.6)

0.739

 Hypertension

50 (43.5)

41 (51.9)

0.305

 CKD

6 (5.2)

4 (5.1)

1.000

Sepsis

51 (44.3)

38 (48.1)

0.661

Mechanical ventilation

96 (83.5)

64 (81.0)

0.703

PaO2/FiO2

316.0 (223.7, 404.0)

284.2 (210.8, 359.15)

0.026

Use of vasopressor

34 (29.6)

34 (43.0)

0.065

Use of diuresis

13 (11.3)

15 (19.0)

0.216

AKI diagnosed by UO criteria

30 (26.1)

35 (44.3)

0.002

Serum creatinine diagnosing AKI (μmol/L)

116.5 (92.3, 186.4)

137.4 (98.5, 230.6)

 < 0.001

Kinetic GFR for 24 h (mL/min/1.73m2)

55.4 (40.2, 86.3)

38.4 (19.8, 58.7)

 < 0.001

AKI stage 2–3

39 (33.9)

51 (64.5)

 < 0.001

Persistent AKI

38 (33.0)

53 (67.1)

 < 0.001

[TIMP-2]*[IGFBP7] day 0 [(ng/mL)2/1000]

0.3 (0.1, 0.6)

1.1 (0.2, 5.5)

 < 0.001

TIMP-2 day 0 (ng/mL)

3.3 (2.2, 6.3)

8.5 (3.5, 21.5)

 < 0.001

IGFBP7 day 0 (ng/mL)

35.2 (20.0, 90.0)

100.9 (41.2, 329.1)

 < 0.001

[TIMP-2]*[IGFBP7] day 1 [(ng/mL)2/1000]

0.3 (0.1, 0.8)

0.4 (0.2, 1.8)

0.104

TIMP-2 day 1 (ng/mL)

3.6 (2.5, 6.8)

5.9 (2.8, 13.5)

0.591

IGFBP7 day 1 (ng/mL)

70.0 (40.6, 120.4)

73.2 (30.7, 179.5)

0.019

  1. Values are median (interquartile range) or n (%). AKI diagnosed by UO criteria was defined as patients who were diagnosed by UO criteria and/or SCr criteria, meanwhile AKI classification by UO criteria was equal or greater than SCr criteria. Persistent AKI was defined as kidney dysfunction without recovery within 48 h
  2. AKI acute kidney injury, BMI body mass index, APACHE II Acute Physiology and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, COPD chronic obstructive pulmonary disease, CKD chronic kidney disease, UO urine output, SCr serum creatinine, TIMP-2 tissue inhibitor of metalloproteinases-2, IGFBP-7 insulin-like growth factor-binding protein 7
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