Skip to main content

Table 4 Baseline characteristics associated with DLCO alteration at 3, 6 and 12 months

From: Result of one-year, prospective follow-up of intensive care unit survivors after SARS-CoV-2 pneumonia

  3 months 6 months 12 months
  Normal DLCO
N = 49
Altered DLCO
N = 36
p-value Normal DLCO
N = 66
Altered DLCO
N = 12
p-value Normal DLCO
N = 65
Altered DLCO
N = 8
p-value
Age, years 67.3 (59.7–73.3) 68.8 (62.4–72.8) 0.5440 68.6 (60.1–73.3) 67.8 (63.3–71.2) 0.6689 68.7 (60.1–72.9) 66.2 (59.4–71.4) 0.8534
Male 35 (71.4%) 32 (88.9%) 0.0516 49 (74.2%) 12 (100%) 0.0589 50 (76.9%) 7 (87.5%) 0.6760
Length of hospitalization (days) 39 (20–52) 53 (24–80) 0.0313 44 (20–61) 58.5 (24–102) 0.2227 45 (20–65) 60 (54–102) 0.1529
Intensive care unit          
 Obesity          
  Missing data 2 0   2 0   2 0  
  BMI < 25 4 (8.5%) 10 (27.8%) 0.0104 11 (17.2%) 3 (25.0%) 0.6590 11 (17.5%) 2 (25.0%) 0.3387
  BMI ≥ 25—< 30 21 (44.7%) 19 (52.8%)   28 (43.8%) 6 (50.0%)   28 (44.4%) 5 (62.5%)  
  BMI ≥ 30 22 (46.8%) 7 (19.4%)   25 (39.1%) 3 (25.0%)   24 (38.1%) 1 (12.5%)  
 Length of stay in ICU (days) 16.5 (11–22) 19.5 (11–37.5) 0.1016 17 (11–23) 32 (13.5–39) 0.0274 17.5 (11–24) 34 (12.5–39) 0.8534
 Creatinemia 81.6 (68.7–98) 113.3 (84.7–163.8) 0.0005 84.8 (70.4–113) 125.5 (93.6–163.8) 0.0052 88 (71–116.4) 110 (84.6–147.6) 0.1400
 CRP 184.1 (128–259) 193.5 (124.9–276) 0.7329 185.6 (128–270.7) 174.5 (108.5–244.1) 0.4864 189 (121.2–270.7) 143.4 (112.6–193.5) 0.3391
 Score SOFA 3 (2–6) 3 (2–6) 0.8614 3 (2–5) 3 (2–6) 0.8464 3 (2–6) 2.5 (2–5.5) 0.6985
 Neuromuscular blocking agents 40 (83.3%) 31 (86.1%) 0.7276 57 (87.7%) 10 (83.3%) 0.6503 58 (90.6%) 6 (75.0%) 0.2150
 Prone position 35 (72.9%) 27 (75.0%) 0.8298 48 (73.8%) 10 (83.3%) 0.7192 51 (79.7%) 6 (75.0%) 0.6687
 Corticosteroids 17 (34.7%) 19 (52.8%) 0.0955 25 (37.9%) 7 (58.3%) 0.2145 28 (43.1%) 6 (75%) 0.1346
 Non-invasive ventilation support 3 (6.1%) 9 (25.0%) 0.0135 6 (9.1%) 5 (41.7%) 0.0104 7 (10.8%) 3 (37.5%) 0.0728
 PaO2/FiO2 (at Day 0 of ICU) 137.5 (108.8–197.7) 157.5 (118.9–216.2) 0.5292 140 (111.4–206.9) 154.5 (85.5–225) 0.9684 153 (111.4–208.4) 166 (105.4–202.5) 0.8570
  1. Values are presented as medians (interquartile ranges) or number of patients (percentages)
  2. DLCO  diffusing capacity of the lung for carbon monoxide, BMI body mass index, CRP  C-reactive protein, SOFA  Sequential Organ Failure Assessment, PaO2/FiO2  partial pressure of oxygen/fraction of inspired oxygen, ICU  intensive care unit