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Annals of Intensive Care

Table 4 Baseline characteristics associated with DLCO alteration at 3, 6 and 12 months

From: Result of one-year, prospective follow-up of intensive care unit survivors after SARS-CoV-2 pneumonia

 

3 months

6 months

12 months

 

Normal DLCO

N = 49

Altered DLCO

N = 36

p-value

Normal DLCO

N = 66

Altered DLCO

N = 12

p-value

Normal DLCO

N = 65

Altered DLCO

N = 8

p-value

Age, years

67.3 (59.7–73.3)

68.8 (62.4–72.8)

0.5440

68.6 (60.1–73.3)

67.8 (63.3–71.2)

0.6689

68.7 (60.1–72.9)

66.2 (59.4–71.4)

0.8534

Male

35 (71.4%)

32 (88.9%)

0.0516

49 (74.2%)

12 (100%)

0.0589

50 (76.9%)

7 (87.5%)

0.6760

Length of hospitalization (days)

39 (20–52)

53 (24–80)

0.0313

44 (20–61)

58.5 (24–102)

0.2227

45 (20–65)

60 (54–102)

0.1529

Intensive care unit

         

 Obesity

         

  Missing data

2

0

 

2

0

 

2

0

 

  BMI < 25

4 (8.5%)

10 (27.8%)

0.0104

11 (17.2%)

3 (25.0%)

0.6590

11 (17.5%)

2 (25.0%)

0.3387

  BMI ≥ 25—< 30

21 (44.7%)

19 (52.8%)

 

28 (43.8%)

6 (50.0%)

 

28 (44.4%)

5 (62.5%)

 

  BMI ≥ 30

22 (46.8%)

7 (19.4%)

 

25 (39.1%)

3 (25.0%)

 

24 (38.1%)

1 (12.5%)

 

 Length of stay in ICU (days)

16.5 (11–22)

19.5 (11–37.5)

0.1016

17 (11–23)

32 (13.5–39)

0.0274

17.5 (11–24)

34 (12.5–39)

0.8534

 Creatinemia

81.6 (68.7–98)

113.3 (84.7–163.8)

0.0005

84.8 (70.4–113)

125.5 (93.6–163.8)

0.0052

88 (71–116.4)

110 (84.6–147.6)

0.1400

 CRP

184.1 (128–259)

193.5 (124.9–276)

0.7329

185.6 (128–270.7)

174.5 (108.5–244.1)

0.4864

189 (121.2–270.7)

143.4 (112.6–193.5)

0.3391

 Score SOFA

3 (2–6)

3 (2–6)

0.8614

3 (2–5)

3 (2–6)

0.8464

3 (2–6)

2.5 (2–5.5)

0.6985

 Neuromuscular blocking agents

40 (83.3%)

31 (86.1%)

0.7276

57 (87.7%)

10 (83.3%)

0.6503

58 (90.6%)

6 (75.0%)

0.2150

 Prone position

35 (72.9%)

27 (75.0%)

0.8298

48 (73.8%)

10 (83.3%)

0.7192

51 (79.7%)

6 (75.0%)

0.6687

 Corticosteroids

17 (34.7%)

19 (52.8%)

0.0955

25 (37.9%)

7 (58.3%)

0.2145

28 (43.1%)

6 (75%)

0.1346

 Non-invasive ventilation support

3 (6.1%)

9 (25.0%)

0.0135

6 (9.1%)

5 (41.7%)

0.0104

7 (10.8%)

3 (37.5%)

0.0728

 PaO2/FiO2 (at Day 0 of ICU)

137.5 (108.8–197.7)

157.5 (118.9–216.2)

0.5292

140 (111.4–206.9)

154.5 (85.5–225)

0.9684

153 (111.4–208.4)

166 (105.4–202.5)

0.8570

  1. Values are presented as medians (interquartile ranges) or number of patients (percentages)
  2. DLCO  diffusing capacity of the lung for carbon monoxide, BMI body mass index, CRP  C-reactive protein, SOFA  Sequential Organ Failure Assessment, PaO2/FiO2  partial pressure of oxygen/fraction of inspired oxygen, ICU  intensive care unit
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