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Annals of Intensive Care
Fig. 2 | Annals of Intensive Care

Fig. 2

From: Effects of regional citrate anticoagulation on thrombin generation, fibrinolysis and platelet function in critically ill patients receiving continuous renal replacement therapy for acute kidney injury: a prospective study

Fig. 2

Changes in systemic measurements of coagulation over duration of treatment. INR International Normalised Ratio, APTTr activated partial thromboplastin time ratio, TGA thrombin generation assay, PFSCA platelet function assay using collagen/adenosine diphosphate, PFSCE platelet function assay using collagen/epinephrine, CT closure time. Repeated measures ANOVAs compared systemic parameters from baseline to 48 h. Post hoc pairwise comparisons found significant differences between haemoglobin at baseline and 36 h (p = 0.030) and baseline and 48 h (p = 0.018); platelets at baseline and 36 h (p = 0.035) and baseline and 48 h (p = 0.040) and INR at baseline and 36 h (p = 0.034) and baseline and 48 h (p = 0.024). There were no significant differences in systemic parameters on CRRT

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