Table 3 Summary of the studies investigating the effects on the outcome of strategies using an assessment of preload responsiveness of critically ill patients
First author (year of publication) | Number of patients | Number of centres | Primary end-point | Effect of fluid administration* | Effect on mortality* | Other tested effects* | |||
|---|---|---|---|---|---|---|---|---|---|
Chen [96] | 82 | 1 | Volume of fluids administered by days 3 and 5 and cumulative fluid balance by days 3 and 5 | Fluid balance at Day-3 | 1 952 [48–5003] mL vs 3 124 [767–10103] mL, p = 0.20 | In-hospital | 56% vs. 49%, p = 0.51 | Ventilator-free days | 5.5 [0–12.25] days vs 5.5 [0–16.75] days, p =0 .05 |
Need for renal replacement therapy | 41.5% vs 39.0%, p = 0.82 | ||||||||
Vasopressor-free days | 5.5 [0–10] days vs 5 [0–16] days, p = 0.84 | ||||||||
Richard [97] | 60 | 1 | Duration of cardiovascular failure | Daily volume of fluids for volume expansion | 383 (211 to 604) mL/day vs 917 (639 to 1,511) mL/day, p = 0.01 | 28-day | 23% vs. 47%, p = 0.10 | Time to shock resolution | 2.0 (1.2 to 3.1) days vs 2.3 (1.4 to 5.6) days, p = 0.29 |
Red cell transfusions | 103 (0 to 183) mL vs 178 (82 to 304) mL, p = 0.04 | ||||||||
Ventilator-free days | 14 [0–24] days vs 8 [0–21] days, p = 0.35 | ||||||||
Douglas [95] | 150 | 13 | Positive fluid balance at 72 h or ICU discharge | Fluid balance at 72 h or ICU discharge | 0.65 ± 2.85 L vs 2.02 ± 3.44 L, p = 0.02 | 30-day | 20% vs. 21%, p = 0.42 | Need for rate of renal replacement therapy | 5.1% vs 17.5%, p = 0.04 |
Need mechanical ventilation | 17.7% ± 34.1%, p = 0.04 | ||||||||