Comparison of clinical characteristics and hospital mortality in critically ill patients without COVID-19 before and during the COVID-19 pandemic: a multicenter, retrospective, propensity score-matched study

Annals of Intensive Care

Table 3 Univariate and Multivariate Cox proportional hazard regression analysis for in-hospital mortality in propensity score matched patients

	Univariate logistic regression analysis			Multivariate logistic regression analysis
	Odds ratio	95% confidence interval	p value	Odds ratio	95% confidence interval	p value
Age > 70	1.779	1.325–2.389	< 0.001	0.758	0.457–1.259	0.284
Sex	0.885	0.654–1.196	0.425
Charlson comorbidity index	1.266	1.166–1.374	< 0.001	1.099	0.962–1.256	0.165
SAPS 3	1.089	1.075–1.103	< 0.001	1.065	1.048–1.081	< 0.001
SOFA on ER admission	1.322	1.261–1.386	< 0.001	1.148	1.078–1.224	< 0.001
SOFA on ICU admission	1.376	1.311–1.444	< 0.001
Cause of admission			< 0.001			0.286
Respiratory disease	3.032	1.930–4.762	0.001	1.091	0.591–2.011	0.781
Cardiovascular disease	1.929	1.142–3.259	0.014	1.827	0.901–3.708	0.095
Liver cirrhosis	3.660	1.922–6.969	< 0.001	0.918	0.355–2.378	0.861
Infectious disease	3.762	2.308–6.130	< 0.001	1.520	0.798–2.896	0.202
Other metabolic	Reference			Reference
ER length of stay	0.989	0.974–1.005	0.167
Do-not-resuscitation order	10.728	7.303–15.760	< 0.001	8.160	5.072–13.130	< 0.001
COVID-19 pandemic	1.260	0.942–1.685	0.120	1.405	0.937–2.107	0.100

SAPS 3, simplified acute physiology score 3; SOFA, sequential organ failure assessment; ER, emergency room; COVID-19, corona virus disease 2019