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Table 3 Characteristics of CAR-T cells patients according to the reason for ICU admission

From: The use of ICU resources in CAR-T cell recipients: a hospital-wide study

Characteristic CRS n = 33 CRS or sepsis n = 13 Disease progression n = 4 Sepsis n = 21 p
Demographics
 Age 56 [27–69] 60 [48–67] 60 [48–64] 65 [44–67] 0.8
 Male gender 16 (48.5%) 10 (77%) 4 (100%) 12 (57%) 0.11
Body mass index (kg/m2)
 Performance status 1 [1–1] 1 [1–2] 2 [2–2] 2 [1–2] 0.04
 Hematological malignancy      0.84
  - Diffuse large B cell lymphoma 24 (73%) 10 (77%) 4 (100%) 15 (71%)  
  - Lymphoblastic leukemia 8 (24%) 3 (23%) 0 6 (29%)  
- Multiple myeloma 1 (3%) 0 0 0  
 Median number of previous treatment lines 3 [2–4] 4 [4–5] 4 [3–5] 4 [3–4] 0.01
 Delay between CAR-T cell and ICU admission (days) 6 [4–7] 6 [4–8] 0.5 [− 0.25 to 1] 6 [5–8] 0.01
Clinical features at ICU admission
 Mean arterial blood pressure (mmHg) 69 [60–80] 62 [59–77] 79 [72–86] 66 [62–73] 0.45
 Temperature (°C) 39.3 [38.7–39.9] 40.2 [39.4–40.5] 37.5 [36.7–38.2] 39.8 [38.8–40] 0.006
Biological features at ICU admission
 Leucocytes (× 109/L) 0.66 [0.2–1.07] 0.54 [0.1–7.06] 0.58 [0.24–1.11] 0.34 [0.1–1.28] 0.81
 Hemoglobin (g/dL) 9.1 [8.6–9.5] 8.6 [8.4–9.2] 8.9 [8.8–9.1] 9 [8.1–9.2] 0.57
 Platelets (× 109/L) 72 [48–151] 90 [47–149] 88 [70–95] 78 [18–124] 0.74
 Fibrinogen (g/L) 5.1 [4.3–5.8] 6 [4.7–6.9] 4.7 [4.6–5.4] 5.6 [4.9–6.4] 0.54
 Creatinin (µmol/L) 61 [52–83] 69 [54–121] 78 [43–117] 57 [48–90] 0.63
 Bilirubin (µmol/L) 8.7 [5.6–12.1] 7.6 [6.1–9.9] 14 [9.7–21.1] 6.1 [5–15.5] 0.56
 Ferritin (µmol/L) 943 [514–1820] 1184 [643–4238] 7692 [6603–8782] 2434 [912–6114] 0.09
 LDH (UI/L) 429 [322–654] 421 [296–507] 611 [525–955] 363 [248–617] 0.37
 Lactate (mmol/L) 1.2 [0.8–1.9] 1.7 [1.1–2.7] 1.6 [1.2–1.9] 1.5 [1–2.1] 0.64
 SOFA score 4 [2–5] 5 [3–6] 3.5 [2.5–4.5] 4 [2–7] 0.5
Non-specific treatments in the ICU at day 1
 Fluid resuscitation at day 1 (mL) 500 [0–1500] 1500 [0–2000] 0 [0–0] 1000 [0–2000] 0.04
 Vasopressors 8 (24%) 4 (31%) 0 6 (29%) 0.64
 Mechanical ventilation 1 (3%) 0 0 1 (5%) 0.85
 Renal replacement therapy 0 1 (8%) 0 0 0.21
Outcome
 Death in the ICU 0 1 (8%) 0 0 0.21
 Death in the hospital 2 (6.1%) 2 (15%) 1 (25%) 3 (16%) 0.53
  1. ICU intensive care unit; SOFA Sepsis–related Organ Failure Assessment