Table 3 Characteristics of CAR-T cells patients according to the reason for ICU admission
From: The use of ICU resources in CAR-T cell recipients: a hospital-wide study
Characteristic | CRS n = 33 | CRS or sepsis n = 13 | Disease progression n = 4 | Sepsis n = 21 | p |
|---|---|---|---|---|---|
Demographics | |||||
Age | 56 [27–69] | 60 [48–67] | 60 [48–64] | 65 [44–67] | 0.8 |
Male gender | 16 (48.5%) | 10 (77%) | 4 (100%) | 12 (57%) | 0.11 |
Body mass index (kg/m2) | |||||
Performance status | 1 [1–1] | 1 [1–2] | 2 [2–2] | 2 [1–2] | 0.04 |
Hematological malignancy | 0.84 | ||||
- Diffuse large B cell lymphoma | 24 (73%) | 10 (77%) | 4 (100%) | 15 (71%) | |
- Lymphoblastic leukemia | 8 (24%) | 3 (23%) | 0 | 6 (29%) | |
- Multiple myeloma | 1 (3%) | 0 | 0 | 0 | |
Median number of previous treatment lines | 3 [2–4] | 4 [4–5] | 4 [3–5] | 4 [3–4] | 0.01 |
Delay between CAR-T cell and ICU admission (days) | 6 [4–7] | 6 [4–8] | 0.5 [− 0.25 to 1] | 6 [5–8] | 0.01 |
Clinical features at ICU admission | |||||
Mean arterial blood pressure (mmHg) | 69 [60–80] | 62 [59–77] | 79 [72–86] | 66 [62–73] | 0.45 |
Temperature (°C) | 39.3 [38.7–39.9] | 40.2 [39.4–40.5] | 37.5 [36.7–38.2] | 39.8 [38.8–40] | 0.006 |
Biological features at ICU admission | |||||
Leucocytes (× 109/L) | 0.66 [0.2–1.07] | 0.54 [0.1–7.06] | 0.58 [0.24–1.11] | 0.34 [0.1–1.28] | 0.81 |
Hemoglobin (g/dL) | 9.1 [8.6–9.5] | 8.6 [8.4–9.2] | 8.9 [8.8–9.1] | 9 [8.1–9.2] | 0.57 |
Platelets (× 109/L) | 72 [48–151] | 90 [47–149] | 88 [70–95] | 78 [18–124] | 0.74 |
Fibrinogen (g/L) | 5.1 [4.3–5.8] | 6 [4.7–6.9] | 4.7 [4.6–5.4] | 5.6 [4.9–6.4] | 0.54 |
Creatinin (µmol/L) | 61 [52–83] | 69 [54–121] | 78 [43–117] | 57 [48–90] | 0.63 |
Bilirubin (µmol/L) | 8.7 [5.6–12.1] | 7.6 [6.1–9.9] | 14 [9.7–21.1] | 6.1 [5–15.5] | 0.56 |
Ferritin (µmol/L) | 943 [514–1820] | 1184 [643–4238] | 7692 [6603–8782] | 2434 [912–6114] | 0.09 |
LDH (UI/L) | 429 [322–654] | 421 [296–507] | 611 [525–955] | 363 [248–617] | 0.37 |
Lactate (mmol/L) | 1.2 [0.8–1.9] | 1.7 [1.1–2.7] | 1.6 [1.2–1.9] | 1.5 [1–2.1] | 0.64 |
SOFA score | 4 [2–5] | 5 [3–6] | 3.5 [2.5–4.5] | 4 [2–7] | 0.5 |
Non-specific treatments in the ICU at day 1 | |||||
Fluid resuscitation at day 1 (mL) | 500 [0–1500] | 1500 [0–2000] | 0 [0–0] | 1000 [0–2000] | 0.04 |
Vasopressors | 8 (24%) | 4 (31%) | 0 | 6 (29%) | 0.64 |
Mechanical ventilation | 1 (3%) | 0 | 0 | 1 (5%) | 0.85 |
Renal replacement therapy | 0 | 1 (8%) | 0 | 0 | 0.21 |
Outcome | |||||
Death in the ICU | 0 | 1 (8%) | 0 | 0 | 0.21 |
Death in the hospital | 2 (6.1%) | 2 (15%) | 1 (25%) | 3 (16%) | 0.53 |