Infected pancreatic necrosis complicating severe acute pancreatitis in critically ill patients: predicting catheter drainage failure and need for necrosectomy

Annals of Intensive Care

Table 2 Univariate regression analysis to identify predictors of catheter-drainage failure

	Odds ratio	95% CI	P value
Baseline characteristics and CTSI
Age	1.01	[0.98; 1.04]	0.5388
Male	1.08	[0.33; 3.52]	0.8944
BMI	1.11	[1.01; 1.22]	0.0246
SOFA	1.02	[0.94; 1.14]	0.39
Persistent organ failure^a, after the first 48 h
Respiratory failure	2.40	[0.74; 7.75]	0.1431
Hemodynamic failure	2.49	[0.60; 10.32]	0.2071
Renal failure	1.38	[0.30; 6.27]	0.6760
Complications during the 24 h before first drainage
Respiratory failure	4.62	[1.62; 13.21]	0.0043
Hemodynamic failure	1.86	[0.56; 6.15]	0.3078
Renal failure	1.76	[0.40; 7.67]	0.4531
Data on last CT before drainage
CTSI before drainage	1.20	[0.98; 1.48]	0.07
% of pancreatic necrosis
Pancreatic necrosis < 30%	0.46	[0.17; 1.25]	0.12
Pancreatic necrosis ≥ 30 < 50%	0.69	[0.19; 2.55]	0.58
Pancreatic necrosis ≥ 50%	3.47	[1.07; 11.19]	0.03
Heterogeneous collection	2.44	[0.84; 7.06]	0.10
Gas bubbles in collection on CT	1.23	[0.38; 4.06]	0.72
Acute necrotic collection	0.00	[0.00; I]*	0.9799
Walled-off necrosis	1.87	[0.32; 11.00]	0.4883
PSM vein thrombosis	0.98	[0.34; 2.84]	0.96
PSM vein narrowing	2.33	[0.86; 6.29]	0.09
Drainage modalities
Time from diagnosis to drainage (per additional day)	1.04	[1.00; 1.07]	0.0663
Antibiotic therapy ≥ 48 h before drainage	0.72	[0.27; 1.93]	0.5154
Second drainage (percutaneous or endoscopic)	15.05	[1.80; 125.95]	0.0124

95% CI 95% confidence interval, CTSI computed tomography severity index, BMI: body mass index, SOFA Sequential Organ Failure Assessment, PSM: portosplenomesenteric. Bold numbers indicate p<=0.05
^aOrgan failure was defined as a SOFA subscore ≥ 2 for the respiratory, renal, and/or hemodynamic components