Fluid accumulation and major adverse kidney events in sepsis: a multicenter observational study

Mele, Alessandro; Cerminara, Emanuele; Häbel, Henrike; Rodriguez-Galvez, Borja; Oldner, Anders; Nelson, David; Gårdh, Johannes; Thobaben, Ragnar; Jonmarker, Sandra; Cronhjort, Maria; Hollenberg, Jacob; Mårtensson, Johan

doi:10.1186/s13613-022-01040-6

Annals of Intensive Care

Table 4 Type and volume of administered fluids and urine output during the first 2 days in ICU

From: Fluid accumulation and major adverse kidney events in sepsis: a multicenter observational study

Fluid type	No MAKE30 (n = 1315)			MAKE30 (n = 519)
Fluid type	No. of patients^a	Median (IQR) volume (ml)^b	% of total fluid volume^c	No. of patients^a	Median (IQR) volume (ml)^b	% of total fluid volume^c
Total fluid input	1315	8395 (6233–11,130)	100	519	8559 (6245–11,531)	100
Resuscitation fluids
Ringer’s solution	1235	3500 (2000–5357)	41.7	481	3460 (2000–5670)	41.0
Albumin 40 or 50 g/l	359	500 (481–1000)	2.6	139	750 (490–1289)	2.8
Albumin 200 g/l	498	200 (100 – 348)	1.2	240	200 (100–400)	1.5
Hydroxyethyl starch	212	963 (500–1014)	1.8	77	1000 (500–1461)	1.7
Dextran	111	600 (500–1000)	0.8	28	733 (500–1000)	0.6
Gelofusine	117	1500 (500–2000)	1.4	30	1000 (500–1500)	0.8
	Proportion of total fluid input from resuscitation fluids		49.5	Proportion of total fluid input from resuscitation fluids		48.4
Non resuscitation fluids
0.9% saline	1099	432 (152–921)	6.9	451	506 (201–1178)	9.2
Glucose 25–200 g/l	1283	2106 (1428–2891)	24.3	509	2082 (1316–2954)	23.6
Glucose 300–500 g/l	6	25 (20–40)	< 0.1	9	30 (20–90)	< 0.1
Red blood cells	458	500 (250–750)	2.6	197	500 (250–750)	2.8
Plasma	342	1000 (500–1750)	4.3	147	750 (500–1500)	3.9
Platelets	123	600 (300–650)	0.6	100	600 (300–900)	1.5
Parenteral nutrition	909	182 (12–1096)	5.2	353	112 (11.8–1239)	5.3
Enteral (oral or nasogastric) fluids	435	710 (325–1300)	3.5	125	425 (200–800)	1.9
Enteral nutrition (IQR)	345	326 (163–566)	1.4	136	295 (171–495)	1.4
Electrolyte solutions	1215	78 (36–143)	1.2	474	94 (39–199)	1.6
Other fluids	109	100 (40–280)	0.3	64	169 (50–462)	0.4
	Proportion of total fluid input from non-resuscitation fluids		50.5	Proportion of total fluid input from non-resuscitation fluids		51.6
Total urine output	1305	4215 (2821–6098)		511	3081 (1580–4787)

^aTotal number of patients who received the fluid type presented on each row
^bMedian (IQR) delivered volume of each fluid (among those who received the specific fluid type)
^cProportion of total fluid intake in the No MAKE30 group and MAKE30 group, respectively

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