Impact on 6-month outcomes of hospital trajectory in critically ill older patients: analysis of the ICE-CUB2 clinical trial

Annals of Intensive Care

Table 2 Factors associated with 6-month overall survival—multivariate analysis

Variables	Hazard ratio (95% CI)^a	p value
Hospital destination (vs IMCU)
AMW	1.31 (1.04–1.63)	0.019
ICU	1.17 (0.95–1.46)	0.147
Age (per one-point increase)	1.04 (1.03–1.05)	< 0.001
Male sex (vs female)	1.19 (1.04–1.36)	0.012
Presence of comorbidities	1.04 (0.90–1.20)	0.562
SAPS-3 (per one-point increase)	1.05 (1.04–1.05)	< 0.001
ADL (per one-point decrease)	1.15 (1.06–1.25)	< 0.001
Admission diagnosis (ref: cardiac disorder)
Surgery	0.97 (0.59–1.61)	0.909
Coma	1.56 (1.21–2.02)	< 0.001
Respiratory failure	0.92 (0.74–1.15)	0.465
Gastrointestinal tract disorder	0.67 (0.46–0.97)	0.034
Shock	0.80 (0.62–1.01)	0.065
Multiple trauma with no surgery	1.08 (0.44–2.65)	0.870
Acute kidney injury	0.97 (0.69–1.36)	0.865
Other	0.79 (0.59–1.05)	0.102

Multivariate analysis using Cox model with the following variables: SAPS-3, gender, age, admission diagnosis, invalidating illness, baseline ADL, initial diagnosis
95% CI: 95% confidence interval, ADL: Activity of daily living, ICU: intensive care unit, IMCU: intermediate care unit, HR: hazard ratio, ref: reference, SAPS-3: Simplified Acute Physiology Score 3
^aHR gives the increase of the risk of death per each unit increase for continuous variables and for one specific category vs a reference category for categorical variables (HR > 1: the variable is associated with an increased risk of death or decreased survival)