Table 1 Baseline characteristics of studied population. Parameters and SOFA (Sequential Organ Failure Assessment) were reported at inclusion
From: Kinetics of capillary refill time after fluid challenge
Total N = 29 | Non-responders N = 6 | Responders N = 23 | P value | |
|---|---|---|---|---|
Age, years | 67 [57–71] | 67 [57–68] | 67 [57–71] | 0.85 |
Male gender | 21 (72.4) | 3 (50) | 18 (78) | 0.30 |
Body mass index, kg/m2 | 25 [22–28] | 25 [23–28] | 25 [19–29] | 0.92 |
SAPS II | 57 [45–72] | 46 [44–47] | 61 [50–78] | 0.10 |
SOFA | 7 [5–9] | 5 [4–6] | 7 [5–10] | 0.03 |
Comordibities | ||||
Cardiovascular disease | 5 (17) | 1 (17) | 4 (17) | > 0.99 |
Hypertension | 18 (62) | 2 (33) | 16 (69) | 0.24 |
Cirrhosis | 0 | 0 | 0 | – |
Diabetes mellitus | 12 (41) | 1 (17) | 11 (48) | 0.36 |
Chronic kidney disease | 5 (17) | 0 (0) | 4 (17) | 0.27 |
Malignancy | 12 (41) | 3 (67) | 9 (39) | 0.63 |
Sepsis | ||||
Proven | 21 (72) | 4 (67) | 17 (74) | |
Suspected | 8 (35) | 2 (33) | 6 (26) | 0.72 |
Heart rate, bpm | 109 [95–127] | 124 [89–152] | 106 [95–125] | 0.34 |
MAP, mmHg | 71 [67–82] | 74 [70–79] | 71 [68–83] | 0.94 |
Cardiac index, mL/min/m2 | 3.4 [2.7–4.5] | 3.4 [2.6–4.4] | 3.4 [2.6–4.6] | 0.84 |
CRT fingertip, sec | 3.4 [2.5–4.0] | 2.8 [2.5–3.4] | 3.8 [2.6–4.1] | 0.02 |
Mottling score | 2 [1–3] | 1.5 [0.75–3.25] | 2 [1–3] | 0.51 |
Skin temperature, °C | 29.8 [29.2–31.6] | 29.8 [28.8–31] | 29.9 [29.2–31.9] | 0.89 |
Mechanical ventilation, n (%) | 15 (52) | 1 (17) | 14 (61) | 0.05 |
Crystalloid infused before inclusion (mL) | 1500 [1000–2500] | 1500 [1000–1800] | 1500 [1000–2200] | 0.67 |
Norepinephrine | ||||
Yes, n (%) | 14 (48) | 2 (33) | 12 (52) | 0.41 |
Dose, μg/kg/min | 0 [0–0.40] | 0 [0–0.38] | 0.10 [0–0.40] | 0.53 |
Biological parameters | ||||
Arterial pH | 7.31 [7.26–7.44] | 7.29 [7.10–7.40] | 7.32 [7.27–7.44] | 0.36 |
Arterial lactate, mmol/L | 2.4 [1.4–3.3] | 2.3 [1.3–3.4] | 2.4 [1.3–3.8] | 0.80 |
Leukocyte count, G/L | 13.4 [6.6–18.8] | 10.6 [5.5–18.6] | 13.4 [7.0–19.3] | 0.72 |
Hemoglobin, g/dL | 13.1 [10.3–13.8] | 11.7 [9.2–13.7] | 13.3 [11–13.9] | 0.29 |
Platelet count, G/L | 172 [105–233] | 161 [107–289] | 172 [105–233] | 0.84 |
Serum creatinin, μmol/L | 127 [96–189] | 104 [99–117] | 131 [84–241] | 0.18 |
Sodium, mmol/L | 136 [130–139] | 137 [130–140] | 136 [129–139] | 0.94 |
Protidemia, g/L | 58 [49–62] | 59 [49–62] | 55 [49–63] | 0.98 |
Bilirubin, μmol/L | 14 [10–18] | 15 [9–27] | 14 [10–19] | 0.85 |
C reactive protein, mg/L | 137 [30–390] | 161 [75–282] | 100 [4–398] | 0.76 |
Procalcitonin, ng/L | 10.3 [2.9–65] | 13.5 [5.7–87.8] | 10.5 [1.2–63.6] | 0.48 |
Death in ICU, n (%) | 7 (24) | 0 (0) | 7 (30) | 0.12 |