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Table 1 Baseline characteristics of studied population. Parameters and SOFA (Sequential Organ Failure Assessment) were reported at inclusion

From: Kinetics of capillary refill time after fluid challenge

  Total N = 29 Non-responders N = 6 Responders N = 23 P value
Age, years 67 [57–71] 67 [57–68] 67 [57–71] 0.85
Male gender 21 (72.4) 3 (50) 18 (78) 0.30
Body mass index, kg/m2 25 [22–28] 25 [23–28] 25 [19–29] 0.92
SAPS II 57 [45–72] 46 [44–47] 61 [50–78] 0.10
SOFA 7 [5–9] 5 [4–6] 7 [5–10] 0.03
Comordibities
 Cardiovascular disease 5 (17) 1 (17) 4 (17)  > 0.99
 Hypertension 18 (62) 2 (33) 16 (69) 0.24
 Cirrhosis 0 0 0
 Diabetes mellitus 12 (41) 1 (17) 11 (48) 0.36
 Chronic kidney disease 5 (17) 0 (0) 4 (17) 0.27
 Malignancy 12 (41) 3 (67) 9 (39) 0.63
Sepsis
 Proven 21 (72) 4 (67) 17 (74)  
 Suspected 8 (35) 2 (33) 6 (26) 0.72
Heart rate, bpm 109 [95–127] 124 [89–152] 106 [95–125] 0.34
MAP, mmHg 71 [67–82] 74 [70–79] 71 [68–83] 0.94
Cardiac index, mL/min/m2 3.4 [2.7–4.5] 3.4 [2.6–4.4] 3.4 [2.6–4.6] 0.84
CRT fingertip, sec 3.4 [2.5–4.0] 2.8 [2.5–3.4] 3.8 [2.6–4.1] 0.02
Mottling score 2 [1–3] 1.5 [0.75–3.25] 2 [1–3] 0.51
Skin temperature, °C 29.8 [29.2–31.6] 29.8 [28.8–31] 29.9 [29.2–31.9] 0.89
Mechanical ventilation, n (%) 15 (52) 1 (17) 14 (61) 0.05
Crystalloid infused before inclusion (mL) 1500 [1000–2500] 1500 [1000–1800] 1500 [1000–2200] 0.67
Norepinephrine
 Yes, n (%) 14 (48) 2 (33) 12 (52) 0.41
 Dose, μg/kg/min 0 [0–0.40] 0 [0–0.38] 0.10 [0–0.40] 0.53
Biological parameters
 Arterial pH 7.31 [7.26–7.44] 7.29 [7.10–7.40] 7.32 [7.27–7.44] 0.36
 Arterial lactate, mmol/L 2.4 [1.4–3.3] 2.3 [1.3–3.4] 2.4 [1.3–3.8] 0.80
 Leukocyte count, G/L 13.4 [6.6–18.8] 10.6 [5.5–18.6] 13.4 [7.0–19.3] 0.72
 Hemoglobin, g/dL 13.1 [10.3–13.8] 11.7 [9.2–13.7] 13.3 [11–13.9] 0.29
 Platelet count, G/L 172 [105–233] 161 [107–289] 172 [105–233] 0.84
 Serum creatinin, μmol/L 127 [96–189] 104 [99–117] 131 [84–241] 0.18
 Sodium, mmol/L 136 [130–139] 137 [130–140] 136 [129–139] 0.94
 Protidemia, g/L 58 [49–62] 59 [49–62] 55 [49–63] 0.98
 Bilirubin, μmol/L 14 [10–18] 15 [9–27] 14 [10–19] 0.85
 C reactive protein, mg/L 137 [30–390] 161 [75–282] 100 [4–398] 0.76
 Procalcitonin, ng/L 10.3 [2.9–65] 13.5 [5.7–87.8] 10.5 [1.2–63.6] 0.48
Death in ICU, n (%) 7 (24) 0 (0) 7 (30) 0.12
  1. SAPS II (Simplified Acute Physiology Score) was calculated within 24 h of admission. Values are given as median (25th–75th percentiles) and percentage according to data distribution. Comparisons were done using non-parametric Mann Whitney test. Patients’ characteristics
  2. ICU intensive care unit, MAP mean arterial pressure, SAPS Simplified Acute Physiology Score, SOFA Score SOFA (Sequential Organ Failure Assessment), CRT capillary refill time
  3. Bold values indicate statistically differences between groups