A burden of fluid, sodium, and chloride due to intravenous fluid therapy in patients with respiratory support: a post-hoc analysis of a multicenter cohort study

Annals of Intensive Care

Table 3 Estimates of the effects of septic shock and hypoxemic respiratory failure to a burden of fluid, sodium, and chloride within 24 h

	Septic shock (95% CI)	P value	Hypoxemic respiratory failure (95% CI)	P value
Fluid volume
Total intravenous fluid, mL	1756.9 (1123.9 to 2390.0)	< 0.001	− 467.2 (− 913.8 to − 20.5)	0.040
Intravenous fluid due to fluid creep, mL	249.8 (47.6 to 452.0)	0.016	− 50.1 (− 192.8 to 92.5)	0.490
Sodium burden
Total sodium burden, mEq	227.0 (143.1 to 310.9)	< 0.001	− 74.0 (− 133.2 to − 14.8)	0.014
Sodium burden due to fluid creep, mEq	14.0 (− 8.4 to 36.4)	0.220	− 0.9 (− 16.7 to 14.9)	0.913
Chloride burden
Total chloride burden, mEq	194.8 (121.5 to 268.2)	< 0.001	− 61.4 (− 113.1 to − 9.7)	0.020
Chloride burden due to fluid creep, mEq	25.3 (2.5 to 48.2)	0.030	− 3.6 (− 19.7 to 12.6)	0.663

Adjusted by the following factors: sex, age, body mass index, emergency admission, cardiovascular disease, APACHE II score, SOFA score, Charlson comorbidity index. Multicollinearity using variance inflation factors was not detected among all covariates
APACHE acute physiology and chronic health evaluation, CI confidence interval, SOFA sequential organ failure assessment