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Annals of Intensive Care
Fig. 2 | Annals of Intensive Care

Fig. 2

From: Adverse outcomes with extracorporeal adsorbent blood treatments in toxic systemic inflammation: a perspective on possible mechanisms

Fig. 2

Removal of protective proteins. A Inter-alpha inhibitor proteins (IαIp) inhibit granzymes (GNZ) and other proteases reducing their toxic proteolytic activity. Matrix metalloproteinase-9 (MMP-9) transits to bone marrow where it mobilizes circulating endothelial progenitor cells (cEPC) to the circulation, promoting healing of microvascular endothelium. B Where matrix adsorption binds IαIp its activity may be reduced leading to disinhibition of proteases which may be injurious. Where adsorption binds MMP-9, mobilization of restorative cEPC may be blunted and their systemic restorative effects diminished or lost

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