Table 2 Baseline LRT pathogens in participants with a baseline R-SOFA ≥ 2 or CV-SOFA ≥ 2 (mITT population)
Variable | Respiratory SOFA component score ≥ 2 | Cardiovascular SOFA component score ≥ 2 | ||
|---|---|---|---|---|
Ceftolozane/tazobactam (n = 225) | Meropenem (n = 222) | Ceftolozane/tazobactam (n = 56) | Meropenem (n = 72) | |
Number of baseline LRT pathogens | ||||
Monomicrobial | 138 (61.3) | 142 (64.0) | 36 (64.3) | 45 (62.5) |
Polymicrobial | 87 (38.7) | 80 (36.0) | 20 (35.7) | 27 (37.5) |
Baseline LRT pathogensa | ||||
Gram-negative | 223 (99.1) | 217 (97.7) | 54 (96.4) | 72 (100) |
Pseudomonas aeruginosa | 52 (23.1) | 58 (26.1) | 14 (25.0) | 14 (19.4) |
AmpC overexpressing | 7 (3.1) | 6 (2.7) | 1 (1.8) | 0 |
Enterobacterales | 171 (76.0) | 169 (76.1) | 38 (67.9) | 60 (83.3) |
ESBL + Enterobacterales | 72 (32.0) | 67 (30.2) | 14 (25.0) | 17 (23.6) |
Citrobacter koseri | 5 (2.2) | 7 (3.2) | 1 (1.8) | 3 (4.2) |
Enterobacter cloacae | 16 (7.1) | 13 (5.9) | 5 (8.9) | 10 (13.9) |
Escherichia coli | 47 (20.9) | 38 (17.1) | 9 (16.1) | 14 (19.4) |
Klebsiella aerogenes | 4 (1.8) | 8 (3.6) | 3 (5.4) | 4 (5.6) |
Klebsiella oxytoca | 13 (5.8) | 9 (4.1) | 5 (8.9) | 6 (8.3) |
Klebsiella pneumoniae | 79 (35.1) | 86 (38.7) | 16 (28.6) | 24 (33.3) |
Proteus mirabilis | 21 (9.3) | 19 (8.6) | 3 (5.4) | 6 (8.3) |
Serratia marcescens | 11 (4.9) | 12 (5.4) | 6 (10.7) | 3 (4.2) |
Acinetobacter baumannii | 18 (8.0) | 12 (5.4) | 3 (5.4) | 1 (1.4) |
Haemophilus influenzae | 18 (8.0) | 16 (7.2) | 5 (8.9) | 8 (11.1) |
Gram-positive | 9 (4.0) | 15 (6.8) | 3 (5.4) | 3 (4.2) |
Streptococcus pneumoniae | 4 (1.8) | 7 (3.2) | 1 (1.8) | 2 (2.8) |