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Annals of Intensive Care

Table 3 Univariable and multivariable logistic regression analyses of factors associated with a complicated hospital coursea

From: Healthcare trajectory of critically ill patients with necrotizing soft tissue infections: a multicenter retrospective cohort study using the clinical data warehouse of Greater Paris University Hospitals

 

N

Univariable analysis

Multivariable analysis

 

Non complicated course

Complicated course

OR [95% CI]

P-value

aOR [95% CI]

P-value

 

N = 46

N = 123

    

Demographic data

 Age

169

59 [52–69]

60 [53–68]

1.00 [0.98; 1.03]

0.724

  

 Sex

169

      

  Male

 

31 (67.4)

89 (72.4)

1.32 [0.63; 2.75]

0.459

  

  Female

 

15 (32.6)

34 (27.6)

Ref

   

Hospital trajectory data

 Annual NSTI procedural volume < 3/year

169

5 (10.9)

33 (26.8)

3.01 [1.09; 8.26]

0.033

  

 Type of structure after ICU

167

   

0.139

  

  Medical ward

 

19 (41.3)

66 (54.6)

Ref.

   

  Rehabilitation

 

5 (10.9)

5 (4.1)

0.29 [0.08; 1.10]

0.069

  

  Plastic surgery

 

7 (15.2)

9 (7.4)

0.37 [0.12; 1.13]

0.080

  

  Other surgical ward

 

15 (32.6)

41 (33.9)

0.79 [0.36; 1.72]

0.548

  

 Inter-hospital transfer

167

      

  No

 

18 (39.1)

61 (50.4)

Ref

   

  Yes

 

28 (60.9)

60 (49.6)

0.63 [0.32; 1.26]

0.194

  

NSTI characteristics

 Hospital-acquired NSTI

169

12 (26.1)

26 (21.1)

0.76 [0.35; 1.67]

0.494

  

 Topography

       

  Upper limb

169

7 (15.2)

17 (13.8)

0.89 [0.34; 2.32]

0.817

  

  Lower limb

169

32 (69.6)

88 (71.5)

1.10 [0.52; 2.31]

0.801

  

  Abdominal/perineal

169

7 (15.2)

26 (21.1)

1.49 [0.60; 3.72]

0.390

  

  Multifocal

169

0

2 (1.6)

–

   

Comorbidities

 Immunosuppression

169

9 (19.6)

34 (27.6)

1.57 [0.69; 3.60]

0.286

  

 PAOD

169

6 (13.0)

20 (16.3)

1.29 [0.48; 3.46]

0.607

  

 Cancer

169

5 (10.9)

9 (7.3)

0.65 [0.20; 2.04]

0.459

  

 Neutropenia

169

2 (4.4)

3 (2.4)

0.55 [0.09; 3.40]

0.520

  

 HIV infection

169

0

4 (3.3)

–

   

 Diabetes

169

23 (50.0)

71 (57.7)

1.37 [0.69; 2.69]

0.369

  

 Chronic heart failure

169

11 (23.9)

26 (21.1)

0.85 [0.38; 1.91]

0.698

  

 COPD

168

5 (10.9)

12 (9.8)

0.89 [0.30; 2.70]

0.843

  

 Cirrhosis

168

2 (4.4)

13 (10.7)

2.62 [0.57; 12.11]

0.216

  

 Chronic hemodialysis

169

0

5 (4.1)

–

   

 Chronic alcohol use

169

8 (17.4)

41 (33.3)

2.38 [1.01; 5.55]

0.046

  

 Previous NSAIDs use

167

14 (30.4)

23 (19.0)

0.54 [0.25; 1.16]

0.115

  

 Obesity

169

13 (28.3)

47 (38.2)

1.57 [0.75; 3.28]

0.231

  

Microbiological data

 Number of isolated bacteria

156

1 [1, 2]

2 [1–4]

1.38 [1.07; 1.78]

0.014

  

 NSTI categorization

154

      

  Type II (monomicrobial)

 

24 (55.8)

41 (36.9)

Ref.

 

Ref.

 

  Type I (polymicrobial)

 

19 (44.2)

70 (63.1)

2.16 [1.06; 4.41]

0.035

3.18 [1.37; 735]

0.007

 Positive blood culture

169

6 (13.0)

44 (35.8)

3.71 [1.46; 9.45]

0.006

3.29 [1.14; 9.52]

0.028

 Isolation of multi / highly resistant bacteria

167

3 (6.5)

26 (21.5)

3.92 [1.13; 13.67]

0.032

  

 Hospital-acquired NSTI

169

12 (26.1)

26 (21.1)

0.76 [0.35; 1.67]

0.494

  

Severity scores

 SAPS II

161

33 [22–45]

53 [33.5–68]

1.05 [1.02; 1.07]

 < 0.001

1.05 [1.02; 1.07]

 < 0.001

 SOFA

161

4 [1–7]

9.5 [5–12]

1.09 [1.01; 1.17]

0.022

  
  1. Qualitative variables are shown as number (percentages) and continuous variables as median [quartile 1-quartile 3]
  2. PAOD peripheral artery occlusive disease, HIV human immunodeficiency virus, COPD chronic obstructive pulmonary disease, NSAIDs non-steroidal anti-inflammatory drugs, NSTI necrotizing soft tissue infection, SAPS Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment score, OR odds ratio, aOR adjusted odds ratio
  3. aDefined by one of the following: a duration of hospital stay ≥ 6 weeks, a number of debridement performed ≥ 3, or hospital death; Area under the ROC curve = 0.796; model calibration (p = 0.442, Hosmer–Lemeshow test)
  4. Bolded variables are significant at the p < 0.05 level
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