Variable (unit) | Timepoint | Isoflurane | Propofol | p | ||||
---|---|---|---|---|---|---|---|---|
 |  | n | Mean (± SD) | SM / LSM change from BL | n | Mean (± SD) | SM / LSM change from BL | (isoflurane vs. propofol) |
PaO2/FiO2 (mmHg) | BL | 72 | 199 (± 58) |  | 90 | 202 (± 62) |  |  |
EOT | 70 | 219 (± 76) | 0.24/19 | 89 | 236 (± 77) | 0.46/358 | 0.185 | |
D7 | 41 | 210 (± 79) | 0.03/3 | 44 | 185 (± 87) | − 0.15/− 13 | 0.411 | |
FiO2 | BL | 72 | 50 (± 14) |  | 90 | 51 (± 16) |  |  |
EOT | 70 | 46 (± 13) | − 0.28/− 3.4 | 89 | 45 (± 12) | − 0.50/− 6.8 | 0.145 | |
PaCO2 | BL | 71 | 45.1 (± 9.9) |  | 90 | 44.6 (± 11.9) |  |  |
EOT | 70 | 47.5(± 10.0) | 0.26/2.7 | 87 | 45.6 (± 8.6) | 0.08/0.9 | 0.264 | |
pH | BL | 71 | 7.4 (± 0.09) |  | 90 | 7.4 (± 0.09) |  |  |
EOT | 44 | 7.4 (± 0.08) | 0.04/0.00 | 50 | 7.4 (± 0.08) | 0.17/0.02 | 0.458 | |
VT (ml/kg) | BL | 72 | 6.6 (± 2.3) |  | 88 | 6.6 (± 2.0) |  |  |
EOT | 56 | 6,4 (± 2,3) | 0.15/0.3 | 61 | 6,6 (± 2.1) | 0.16/0.3 | 0.972 | |
Time to extubation | EOT-extubation | 42 | 38 patients extubated | 55 | 51 patients extubated | 0.456 | ||
30-day mortality | BL-30Â days | 61 | 19 patients died | 80 | 19 patients died | 0.274 | ||
ventilator-free days alive | BL-30 days | 59 | 15.8 (± 11.9) |  | 75 | 15.9 (± 12.0) |  | 0.931 |
Ventilator mode | BL | 72 | Fully controlled: 55.6% Partially assisted: 20.8% Fully assisted: 23.6% | 90 | Fully controlled: 60% Partially assisted: 25.6% Fully assisted: 14.4% | Â | ||
EOT | 70 | Fully controlled: 38.6% Partially assisted: 21.4% Fully assisted: 40% | 89 | Fully controlled: 46.1% Partially assisted: 22.5% Fully assisted: 31.5% | Â |