Table 2 Cox proportional hazards model univariable and multivariable analysis of ICU mortality-associated factors in patients with definite intestinal necrosis
Characteristics of necrosis population | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
CSH | 95% CI | P value | CSH | 95% CI | P value | |
Age (+ 10 years) | 1.32 | 0.92–1.90 | 0.13 | 1.67 | 1.01–2.80 | 0.04 |
Males | 1.44 | 0.61–3.39 | 0.41 | – | – | – |
Body mass index (kg/m2) | 0.99 | 0.92–1.06 | 0.74 | – | – | – |
Diabetes | 0.86 | 0.20–3.71 | 0.85 | – | – | – |
Hypertension | 0.55 | 0.23–1.31 | 0.18 | – | – | – |
Smoking | 1.19 | 0.51–2.77 | 0.68 | – | – | – |
Coronary disease | 0.69 | 0.27–1.79 | 0.45 | – | – | – |
Peripheral arterial disease | 0.66 | 0.15–2.83 | 0.57 | – | – | – |
End stage renal disease | 2.06 | 0.27–16.2 | 0.49 | – | – | – |
Atrial fibrillation | 0.77 | 0.26–2.28 | 0.63 | – | – | – |
Abdominal distension | 2.47 | 1.05–5.86 | 0.04 | 4.99 | 1.62–15.3 | 0.005 |
SOFA at day of suspicion | 0.99 | 0.87–1.13 | 0.93 | – | – | – |
Biological parameters | ||||||
Lactate (mmol/L) | 1.10 | 1.02–1.19 | 0.03 | 1.17 | 1.05–1.30 | 0.005 |
pH (+ 0.1 unit) | 0.69 | 0.50–0.94 | 0.02 | – | – | – |
Bicarbonates | 0.97 | 0.89–1.06 | 0.52 | – | – | – |
LDH (+ 300 units) | 1.02 | 0.99–1.06 | 0.21 | – | – | – |
CPK (+ 1.000 units) | 1.001 | 0.98–1.02 | 1 | – | – | – |
Aspartate transaminase (+ 100 units) | 1.001 | 0.98–1.02 | 0.94 | – | – | – |
Procalcitonin (µg/L) | 0.97 | 0.89–1.06 | 0.52 | – | – | – |
Positive blood cultures | 0.93 | 0.36–2.37 | 0.87 | – | – | – |
Candidemia | 1.50 | 0.43–5.22 | 0.52 | – | – | – |
Specific biomarkers | ||||||
Plasma I-FABP (+ 1.000 units) | 1.02 | 1.01–1.03 | 0.02 | 1.00 | 0.99–1.02 | 0.67 |
Citrulline (µmol/mL) | 1.02 | 0.98–1.05 | 0.32 | – | – | – |
Arginine (µmol/mL) | 1.01 | 0.99–1.02 | 0.09 | – | – | – |
Plasma citrulline/arginine ratio | 1.06 | 0.54–2.08 | 0.87 | – | – | – |
CT findings | ||||||
Abnormal wall enhancement | 0.93 | 0.34–2.48 | 0.87 | – | – | – |
Pneumatosis intestinalis | 1.54 | 0.43–5.48 | 0.50 | – | – | – |
Bowel dilation | 0.76 | 0.28–2.05 | 0.59 | – | – | – |
Portal venous gas | 0.30 | 0.04–2.32 | 0.25 | – | – | – |
Atherosclerosis of mesenteric arteries | 0.89 | 0.29–2.79 | 0.85 | – | – | – |
Organ supports at inclusion | ||||||
Norepinephrine (μg/kg/mn) | 1.20 | 1.03–1.41 | 0.01 | – | – | – |
Mechanical ventilation | 3.07 | 0.41–23.0 | 0.27 | – | – | – |
Renal replacement therapy | 1.10 | 0.32–3.74 | 0.88 | – | – | – |
Surgical treatment | ||||||
Resection | 0.31 | 0.12–0.75 | 0.01 | 0.49 | 0.18–1.33 | 0.16 |