Table 1 Study participant characteristics at sepsis onset in the HYPRESS trial
SIC positive at sepsis onset | SIC positive only after sepsis onset | SIC negative during the entire course of the disease | p value SIC positive at onset vs. SIC negative | |
|---|---|---|---|---|
Total (n = 45) | Total (n = 14) | Total (n = 208) | ||
Male sex—no. (%) | 25/45 (55.6) | 9/14 (64.3) | 144/208 (69.2) | 0.083 |
Age—years | 69 [55–75] | 69.5 [66.3–74.3] | 68 [55–75] | 0.830 |
Type of admission—no. (%) | 0.002 | |||
Surgery (elective) | 5/45 (11.1) | 3/14 (21.4) | 54/207 (26.1) | |
Surgery (emergency) | 5/45 (11.1) | 3/14 (21.4) | 50/207 (24.2) | |
Non-surgery (elective) | 0 | 0 | 8/207 (3.9) | |
Non-surgery (emergency) | 35/45 (77.8) | 8/14 (57.1) | 95 (45.9) | |
SOFA | 8 [7–10] | 6 [4–9] | 5 [4–7] | < 0.001 |
SOFA SIC score adapted | 5 [4–7] | 5.5 [3.8–7.3] | 4 [3–6] | 0.010 |
APACHE II | 19.5 [16–27] | 25 [15.5–28.8] | 17 [14–21] | 0.016 |
SAPS II | 56 [47.5–64.5] | 58 [47.8–73.8] | 53 [46–59] | 0.092 |
SAPS 3 | 65 [57–73.5] | 64 [46–82] | 57 [48.5–64.5] | < 0.001 |
Organ dysfunction—no. (%) | ||||
CNS | 16/45 (35.6) | 4/14 (28.6) | 46/206 (22.3) | 0.085 |
Coagulation | 28/45 (62.2) | 2/14 (14.3) | 11/208 (5.3) | < 0.001 |
Pulmonary | 26/45 (57.8) | 6/14 (42.9) | 153/207 (73.9) | 0.045 |
Renal | 19/45 (42.2) | 7/14 (50.0) | 69/208 (33.2) | 0.300 |
Microcirculatory | 18/45 (40.0) | 8/14 (42.9) | 59/208 (28.4) | 0.153 |