Table 2 Intensive care management and outcomes of patients with severe SARS-CoV-2 infection (n = 925) at intensive care unit admission, according to the presence of auto-antibodies against type I IFNs
Total | Negative anti-IFN auto-Abs | Positive anti-IFN auto-Abs | p-valuea | |
|---|---|---|---|---|
N = 925 | N = 829 | N = 96 | ||
Duration of hospital stay, days (N = 642) | 19.5 (11;37) | 19.0 (11;37) | 22 (13;44) | 0.155 |
Duration of stay in the ICU, days (N = 655) | 12.0 (6;26) | 11.0 (6;25) | 13.0 (7;31) | 0.157 |
Invasive mechanical ventilation | 644 (69.6) | 576 (69.5) | 68 (70.8) | 0.785 |
Duration of mechanical ventilation support. days (N = 643) | 17 (9;28) | 16 (9;28) | 18 (9;30.5) | 0.557 |
Ventilator-free days, 28 days (N = 583) | 1 (0;5) | 1 (0;5) | 2 (0;6) | 0.772 |
Ventilator-free days, 90 days (N = 640) | 0.5 (0;4) | 0 (0;4) | 1 (0;5) | 0.578 |
Ventilator-associated pneumonia (N = 643) | 457 (71) | 406 (70.6) | 51 (75) | 0.450 |
Continuous sedation | 629 (68) | 563 (67.9) | 66 (68.8) | 0.868 |
Neuromuscular blockade | 620 (67) | 553 (66.7) | 67 (69.8) | 0.543 |
Prone positioning | 632 (68.3) | 564 (68) | 68 (70.8) | 0.577 |
Inhaled nitric oxide | 91 (9.8) | 82 (9.9) | 9 (9.4) | 0.872 |
ECMO | 166 (17.95) | 143 (17.3) | 23 (23.96) | 0.105 |
Duration of ECMO support, days | 17 (7;33) | 17 (7;35) | 16 (7;28) | 0.546 |
Renal replacement therapy | 265 (28.7) | 238 (28.7) | 27 (28.1) | 0.773 |
Shock | 507 (54.8) | 455 (54.9) | 52 (54.2) | 0.914 |
Duration of vasopressor support, days (N = 486) | 7 (3;15) | 7 (3;15) | 8 (3;13) | 0.968 |
Vasopressor-free days, 28 days (N = 264) | 14 (6;28) | 14 (6;28) | 16 (8;28) | 0.630 |
Vasopressor-free days, 90 days (N = 261) | 14 (6;28) | 13.5 (6;28) | 16 (8;28) | 0.541 |
Dexamethasone | 678 (73.3) | 614 (74.1) | 64 (66.7) | 0.121 |
Hydrocortisone | 138 (14.9) | 121 (14.6) | 17 (17.7) | 0.418 |
Other corticosteroids | 0.541 | |||
Fludrocortisone | 12 (1.3) | 10 (1.2) | 2 (2.1) | |
Methylprednisolone | 107 (11.6) | 99 (12.0) | 8 (8.3) | |
Prednisone | 17 (1.8) | 15 (1.8) | 2 (2.1) | |
Mortality, 28-day | 214 (23.2) | 196 (23.7) | 18 (18.8) | 0.279 |
Mortality, 90-day | 279 (30.3) | 252 (30.5) | 27 (28.1) | 0.630 |