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Annals of Intensive Care

Table 3 Multivariable logistic regression analysis of factors associated with mortality at 28 days in patients with severe SARS-CoV-2 infection (n = 852)

From: Auto-antibodies against type I IFNs in > 10% of critically ill COVID-19 patients: a prospective multicentre study

 

Day-28 mortality

 

aOR [95% CI]

P value

Anti-IFN auto-antibody

0.69 [0.38–1.25]

0.222

Age, year

1.06 [1.04–1.08]

 < 0.0001

Male gender

1.37 [0.92–2.03]

0.119

Immunosuppressiona

1.81 [1.10–2.98]

0.020

Hypertension

1.11 [0.76–1.61]

0.591

Obesity

1.00 [0.69–1.45]

0.993

Diabetes

0.84 [0.57–1.22]

0.351

SOFA score, per point

1.17 [1.12–1.23]

 < 0.0001

Antibiotic at ICU admission

1.09 [0.75–1.60]

0.641

  1. aOR [95% CI] adjusted odds ratio [95% confidence interval]
  2. Hosmer–Lemeshow Chi2 p-value: 0.403
  3. aRefers to pre-existing immunosuppression; bolded values are significant at the < 0.05 level
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