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Table 2 Association between surge and risk of invasive mechanical ventilation

From: Trends in clinical characteristics and outcomes of all critically ill COVID-19 adult patients hospitalized in France between March 2020 and June 2021: a national database study

Covariates

Invasive MV

Death without invasive MV

Discharge alive without MV

aSHR

95%CI

aSHR

95%CI

aSHR

95%CI

Age (+ 10 years)a

0.92

0.912

2.75

2.69–2.81

0.84

0.83–0.84

Male sex

1.23

1.20–1.26

1.08

1.03–1.13

0.84

0.83–0.86

Arterial hypertension

1.24

1.21–1.27

0.75

0.72–0.78

0.95

0.93–0.96

Diabetes mellitus

1.03

0.99–1.08

1.30

1.20–1.42

0.92

0.87–0.96

Heart disease

0.96

0.92–0.99

1.11

1.05–1.17

0.96

0.93–0.99

Lung disease

1.01

0.98–1.04

1.16

1.08–1.23

0.94

0.92–0.97

Cirrhosis

0.84

0.76–0.93

2.33

1.92–2.82

0.89

0.80–0.99

Cancer

0.51

0.47–0.56

2.13

1.93–2.36

1.09

1.02–1.16

Hematological malignancies

0.88

0.82–0.94

1.21

1.07–1.36

0.97

0.90–1.05

Chronic kidney disease

0.67

0.65–0.70

1.21

1.13–1.29

1.19

1.15–1.24

Immunosuppression

0.83

0.79–0.87

1.88

1.73–2.05

0.90

0.86–0.95

Modified SAPS II

 ≤ 14

Ref

 

Ref

 

Ref

 

 15–20

2.14

2.06–2.23

1.30

1.23–1.38

0.63

0.62–0.64

 21–28

3.70

3.56–3.85

1.51

1.42–1.61

0.41

0.40–0.42

 ≥ 28

6.96

6.71–7.22

1.70

1.60–1.81

0.18

0.17–0.18

Surge

 First

Ref

 

Ref

 

Ref

 

 Second

0.64

0.62–0.66

1.24

1.17–1.32

1.27

1.24–1.30

 Third

0.62

0.61–0.64

1.47

1.39–1.55

1.22

1.19–1.25

  1. aSHR, adjusted sub-hazard ratio; CI, confidence interval; MV, mechanical ventilation; SAPS, simplified acute physiology score
  2. aThe aSHR of age corresponds to SHR for each 10 years in more