Table 1 Included patients’ general characteristics according to ICU survival status
From: Critically ill severe hypothyroidism: a retrospective multicenter cohort study
Characteristic | Total | ICU survivors | ICU nonsurvivors | p |
|---|---|---|---|---|
(n = 82) | (n = 61) | (n = 21) | ||
At ICU admission | ||||
Age (years) | 70 (59–78) | 68 (58–76) | 77 (70–81) | 0.015 |
Female | 61 (74) | 47 (77) | 14 (67) | 0.391 |
SAPS II | 55 (45–70) | 53 (42–66) | 61 (55–88) | 0.005 |
Charlson score | 3 (1–5) | 3 (1–4) | 4 (3–7) | 0.013 |
SOFA score | 8 (6–12) | 7 (5–11) | 12 (8–13) | 0.001 |
Cardiovascular | 3 (0–4) | 1 (0–4) | 4 (4–4) | < 0.001 |
Respiratory | 1 (0–2) | 1 (0–2) | 2 (1–3) | 0.001 |
Neurological | 3 (2–4) | 3 (2–4) | 4 (1–4) | 0.705 |
De novo hypothyroidism | 44 (54) | 32 (52) | 12 (57) | 0.802 |
Etiology | 0.883 | |||
Primary | 76 (93) | 56 (92) | 20 (95) | |
Thyroidectomy | 16 (19) | 13 (21) | 3 (14) | |
Thyroiditis | 24 (29) | 16 (26) | 8 (38) | |
Graves’ disease | 1 (1) | 1 (2) | ||
Atrophic thyroiditis | 1 (1) | 1 (2) | ||
Congenital | 1 (1) | 1 (2) | ||
Unknown | 20 (24) | 16 (26) | 4 (19) | |
Central | 6 (7) | 5 (8) | 1 (5) | |
Trigger | 0.726 | |||
Levothyroxine discontinuation | 23 (28) | 17 (28) | 6 (29) | |
Sepsis | 12 (15) | 9 (15) | 3 (14) | |
Amiodarone | 9 (11) | 5 (8) | 4 (19) | |
Drug-induced hypothyroidism* | 5 (6) | 4 (7) | 1 (5) | |
Unknown | 33 (40) | 26 (43) | 7 (33) | |
Diagnostic score for myxedema comaa | 65 (50–75) | 65 (50–75) | 70 (50–75) | 0.63 |
TSH (mIU/L) | 51.0 (17.5–94.5) | 44.0 (17.2–90.0) | 63.0 (29.8–100.0) | 0.281 |
FT3 (pmol/L) | 1.3 (0.0–2.2) | 1.3 (0.5–2.1) | 0.1 (0.0–2.2) | 0.451 |
FT4 (pmol/L) | 2.7 (0.0–7.5) | 3.0 (0.2–7.8) | 0.9 (0.0–4.9) | 0.247 |