Table 2 Studies describing inflammation and oxidative stress in vivo in RCA CRRT
Author | Tiranathanagul (62) | Schilder (63) | Schilder (64) | Gattas (65) |
|---|---|---|---|---|
Mode | CVVH | CVVH | CVVH | CVVH/CVVHDF |
Comparison | Heparin vs citrate | Heparin vs citrate vs none | Heparin vs citrate vs none | Heparin vs citrate |
Numbers included | 10 vs 10 patients | 8 vs 17 vs 13 patients | 8 vs 17 vs 13 patients | 467 vs 390 circuits in 212 patients |
Markers | MPO, IL-8, TNF-α | IL-6, IL-8 | C5a, elastase, MPO | IL-6, IL-8, IL-10 |
Outcome | At 6Â h pre filter MPO in heparin group higher than baseline, not in citrate. Serum MPO significantly lower in citrate at 24Â h. IL-8 at 6Â h lower than baseline in citrate group, only TNF-a in heparin group, similar trend in citrate group | High inlet IL-6 and IL-8 associated with non-survival, decreased during CVVH. No difference in flux between groups | Total mass production rate of C5a elastase and MPO highest in heparin. Less filter-induced complement activation, neutrophil degranulation and endothelial activation than heparin in citrate | No differences in change from baseline to 2nd measurement between groups |
Remarks | 24 h study | 12 h study | 12 h study | Baseline and measurement at 48–72 h |