Table 1 Demographics and characteristics of patients with NSTI, according to the presence of neutropenia

General characteristics

 Age, years

60.1 ± 13.0

54.2 ± 14.1

0.002

 Sex

  Male

118 (71.5)

48 (63.2)

0.193

  Female

47 (28.5)

28 (36.2)

 Obesity

58/165 (35.2)

12/65 (18.5)

0.01

 Diabetes

92 (55.8)

9 (11.8)

< 0.001

 PAOD

26 (15.8)

1 (1.3)

0.001

 Liver cirrhosis

15/164 (9.1)

2/76 (2.6)

0.067

 HIV infection

4 (2.4)

5 (6.6)

0.145

 Cancer *

10 (6.1)

67 (87)

< 0.001

 COPD

17/164 (10.4)

7/76 (9.2)

0.792

 ESRD requiring dialysis

5 (3.0)

1 (1.3)

0.668

 Alcohol consumption

49 (29.7)

9 (11.8)

0.002

 Long-term steroid therapy

25 (15.2)

21 (27.6)

0.022

 NSAIDs

35/163 (21.5)

1/76 (1.3)

< 0.001

 SAPS II

47.5 ± 22.7

62.1 ± 21.9

< 0.001

Characteristics of NSTI

 Hospital-acquired

38 (23.0)

43 (56.6)

< 0.001

 NSTI location

  Upper Limbs

24 (14.6)

11 (14.5)

0.988

  Lower limbs

117 (70.9)

34 (44.7)

< 0.001

  Abdomino-perineal

31 (18.8)

33 (43.4)

< 0.001

  Cervical

–

7(9.2)

–

  Thoracic

–

3 (3.9)

–

 Monomicrobial documentation

60/149 (40.3)

50/76 (65.8)

< 0.001

 Positive blood culture

49 (29.7)

47 (61.8)

< 0.001

 Surgery

165 (100)

55 (72.4)

< 0.001

 Amputation

26/161 (16.2)

4/76 (5.3)

0.022

 IVIg

12/161 (7.5)

2/76 (2.6)

0.236

 Hyperbaric oxygenotherapy

3/161 (1.9)

1/76 (1.3)

> 0.999

ICU outcomes

 Shock during ICU stay

125/162 (77.2)

65/76 (85.5)

0.166

 Invasive mechanical ventilation during ICU stay

83/161 (51.6)

59/76 (77.6)

< 0.001

 ICU length of stay

15.3 ± 20.8

14.1 ± 14.9

0.61

 ICU mortality

35 (21.2)

39 (51.3)

< 0.001

 Hospital length of stay

49.0 ± 45.1

30.0 ± 30.8

< 0.001

 In-hospital mortality

47 (28.5)

44 (57.9)

< 0.001