Pathogen-based target attainment of optimized continuous infusion dosing regimens of piperacillin-tazobactam and meropenem in surgical ICU patients: a prospective single center observational study

Annals of Intensive Care

Table 1 Dosing regimens for piperacillin-tazobactam and meropenem according to renal function

	Loading dose	Continuous infusion
Piperacillin-tazobactam
Creatinine clearance > 30 mL/min	4/0.5 g given over 30 min	16/2 g every 24 h
Creatinine clearance 15–29 mL/min		12/1.5 g every 24 h
Creatinine clearance < 15 mL/min		8/1 g every 24 h
Intermittent RRT		8/1 g every 24 h + repeat loading dose within 2 h after every RRT session
Continuous RRT		12/1.5 g every 24 h
Meropenem
Creatinine clearance > 30 mL/min	1 g given over 30 min	3 g every 24 h
Creatinine clearance 15–29 mL/min		2 g every 24 h
Creatinine clearance < 15 mL/min		1 g every 24 h
Intermittent RRT		1 g every 24 h + repeat loading dose within 2 h after every RRT session
Continuous RRT		3 g every 24 h
Meropenem high dose	2 g given over 30 min	6 g every 24 h