Table 2 Comparative susceptibility to cefiderocol versus ceftazidime–avibactam, ceftolozane–tazobactam, imipenem–relebactam, meropenem–vaborbactam, colistin of Gram-negative bacterial species
|  | Cefiderocol | Ceftazidime–avibactam | Ceftolozane–tazobactam | Imipenem–relebactam | Meropenem–vaborbactam | Colistina | Refs | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  | MIC90 (µg/mL) | Susceptibility rate (%) | MIC90 (µg/mL) | Susceptibility rate (%) | MIC90 (µg/mL) | Susceptibility rate (%) | MIC90 (µg/mL) | Susceptibility rate (%) | MIC90 (µg/mL) | Susceptibility rate (%) | MIC90 (µg/mL) | Susceptibility rate (%) |  | ||||||
CLSI | EUCAST | CLSI | EUCAST | Â | CLSI | EUCAST | Â | CLSI | EUCAST | Â | CLSI | EUCAST | Â | CLSI | EUCAST | Â | |||
Enterobacterales | 1 | 99.8 | 98.3 | 0.5 | 99.2 | NR | 2 | 91.7 | NR | NT | NT | NT | NT | NT | NT | 1 | 96.8 | NR | [28] |
0.5 | 99.8 | 99.1 | 0.25 | 99.5 | 99.5 | NT | NT | NT | 0.5 | 94.8 | 98.9b | 0.06 | 99.4 | 99.5 |  > 8 | 83.6 | 83.6 | [30] | |
CRE | 4 | 96.7 | 79.9 |  > 64 | 77.0 | NR |  > 64 | 7.8 | NR | NT | NT | NT | NT | NT | NT |  > 8 | 80.5 | NR | [28] |
4 | 98.2 | 87.6 |  > 32 | 81.7 | 81.7 | NT | NT | NT |  > 8 | 63.9 | 71.0b |  > 8 | 71.0 | 75.7 |  > 8 | 78.7 | 78.7 | [30] | |
M/V-R Enterobacterales | 4 | 95.1 | 70.7 |  > 32 | 43.9 | 43.9 | NT | NT | NT |  > 8 | 2.4 | 7.3b |  > 8 | 0 | 0 |  > 8 | 48.8 | 48.8 | [30] |
I/R-R Enterobacterales | 4 | 95.9 | 69.4 |  > 32 | 40.8 | 40.8 | NT | NT | NT |  > 8 | 0 | 0b |  > 8 | 16.3 | 24.5 |  > 8 | 55.1 | 55.1 | [30] |
CZA-R Enterobacterales | 8 | 89.2 | 54.1 |  > 32 | 0 | 0 | NT | NT | NT |  > 8 | 5.4 | 8.1b |  > 8 | 29.7 | 37.8 |  > 8 | 56.8 | 56.8 | [30] |
P. aeruginosa | 0.5 | 99.9 | 99.4 | 8 | 93.8 | NR | 2 | 94.0 | NR | NT | NT | NT | NT | NT | NT | 2 | 99.3 | NR | [28] |
0.5 | 99.6 | 99.4 | 4 | 96.4 | 96.4 | 2 | 96.1 | 96.1 | 1 | 96.4 | 96.4 | NT | NT | NT | 1 | 99.6 | 99.6 | [30] | |
CR P. aeruginosa | 1 | 99.8 | 98.5 | 32 | 75.0 | NR |  > 64 | 76.1 | NR | NT | NT | NT | NT | NT | NT | 1 | 98.5 | NR | [28] |
XDR P. aeruginosa | 1 | 97.3 | 96.9 | 32 | 73.4 | 73.4 |  > 16 | 72.3 | 72.3 |  > 8 | 73.0 | 73.0 | NT | NT | NT | 1 | 99.2 | 99.2 | [30] |
XDR P. aeruginosa | 4 | 97.4 | NA |  > 16 | 57.0 | NA | 32 | 66.8 | NA | 16 | 49.8 | NA | NT | NT | NT | NT | NT | NT | [128] |
C/T-R P. aeruginosa | 8 | 88.3 | 85.0 |  > 32 | 25.0 | 25.0 |  > 16 | 0 | 0 |  > 8 | 43.3 | 43.3 | NT | NT | NT | 1 | 100 | 100 | [30] |
I/R-R P. aeruginosa | 1 | 100 | 100 |  > 32 | 35.4 | 35.4 |  > 16 | 20.8 | 20.8 |  > 8 | 0 | 0 | NT | NT | NT | 1 | 100 | 100 | [30] |
CZA-R P. aeruginosa | 4 | 91.6 | 89.2 |  > 32 | 0 | 0 |  > 16 | 37.3 | 37.3 |  > 8 | 47.0 | 47.0 | NT | NT | NT | 1 | 100 | 100 | [30] |
A. baumannii | 1 | 96.0 | 94.1 |  > 64 | NA | NA |  > 64 | NA | NA | NT | NT | NT | NT | NT | NT | 2 | 92.7 | NR | [28] |
1 | 97.7 | 95.7c | NT | NT | NT | NT | NT | NT |  > 8 | 53.1 | 53.1 | NT | NT | NT | 8 | 86.3 | 86.3 | [30] | |
CR A. baumannii | 2 | 94.2 | 91.1 |  > 64 | NA | NA |  > 64 | NA | NA | NT | NT | NT | NT | NT | NT |  > 8 | 87.2 | NR | [28] |
2 | 95.8 | 91.5c | NT | NT | NT | NT | NT | NT |  > 8 | 0.3 | 0.3 | NT | NT | NT |  > 8 | 76.4 | 76.4 | [30] | |
S. maltophilia | 0.25 | 98.6 | 99.6 | 64 | NA | NA |  > 64 | NA | NA | NT | NT | NT | NT | NT | NT |  > 8 | NA | NA | [28] |
0.5 | 97.9 | 99.7c | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT |  > 8 | NA | NA | [30] | |
Achromobacter spp. | 0.5 | NA | NA | 16 | NA | NA | NT | NT | NT | 2 | NA | NA | 4 | NA | NA | 4 | NA | NA | [29] |
CR Achromobacter spp. | 4 | NA | NA |  > 16 | NA | NA | NT | NT | NT |  > 16 | NA | NA |  > 16 | NA | NA | 8 | NA | NA | [29] |
Burkholderia spp. | 0.5 | NA | NA | 8 | NA | NA | 32 | NA | NA | NT | NT | NT | NT | NT | NT |  > 8 | NA | NA | [28] |
0.5 | NA | NA | 8 | NA | NA | 32 | NA | NA | 4 | NA | NA | 4 | NA | NA |  > 8 | NA | NA | [147] | |
CR Burkholderia spp. | 1 | NA | NA | 16 | NA | NA |  > 64 | NA | NA | 4 | NA | NA | 4 | NA | NA |  > 8 | NA | NA | [147] |