Table 2 Clinical characteristics of patients with COVID-19-related acute respiratory distress syndrome receiving inhaled nitric oxide, according to the oxygenation response within 6 h
ADa | All patients N = 151 | Oxygenation response at H6 | p value | ||
|---|---|---|---|---|---|
Yes N = 69 | No N = 82 | ||||
Patient’s characteristics | |||||
Age, years | 151 | 65 (56–72) | 66 (53–72) | 65 (56–72) | 0.929 |
Women, n (%) | 151 | 31 (20.5%) | 11 (16%) | 20 (24%) | 0.200 |
Body Mass Index ≥ 30 kg/m2 | 144 | 72 (50%) | 30 (46%) | 42 (54%) | 0.316 |
At least one comorbidity | 151 | 110 (72.8%) | 48 (69.6%) | 62 (75.6%) | 0.405 |
Treated hypertension | 68 (45.0%) | 31 (44.9%) | 37 (45.1%) | 0.981 | |
Diabetes | 60 (39.7%) | 22 (31.9%) | 38 (46.3%) | 0.071 | |
COPD | 11 (7.3%) | 5 (7.2%) | 6 (7.3%) | 0.987 | |
Immunodeficiency | 11 (7.3%) | 5 (7.2%) | 6 (7.3%) | 0.987 | |
Condition at ICU admission | |||||
SAPS II score | 114 | 35 (29–45) | 40 (29–51) | 34 (28–39) | 0.054 |
SOFA score | 119 | 4 (3–7) | 4 (3–8) | 5 (4–7) | 0.703 |
Cardiovascular SOFA score | 109 | 1 (0–3) | 0 (0–3) | 2 (0–3) | 0.601 |
Condition within 6 h before iNO initiation | |||||
SOFA score | 114 | 8 (5–12) | 8 (5–12) | 8 (5–13) | 0.798 |
Renal SOFA score | 94 | 0 (0–2) | 0 (0–1) | 0 (0–2) | 0.326 |
Cardiovascular SOFA score | 120 | 3 (0–4) | 3 (0–4) | 1 (0–4) | 0.455 |
Biological parameters before iNO initiation | |||||
Creatinine, µmol/L | 144 | 90 (62–187) | 80 (62–140) | 107 (62–236) | 0.184 |
Platelets, G/L | 102 | 241 (196–320) | 231 (196–297) | 249 (188–368) | 0.410 |
Outcomes | |||||
ICU length of stay in survivors, days | 62 | 38 (26–51) | 38 (27–44) | 41 (22–55) | 0.871 |
Hospital length of stay in survivors, days | 59 | 49 (39–73) | 48 (41–79) | 53 (36–70) | 0.538 |
ICU mortality | 151 | 86 (57.0%) | 35 (50.7%) | 51 (62.2%) | 0.156 |
Hospital mortality | 151 | 89 (58.9%) | 36 (52.2%) | 53 (64.6%) | 0.121 |