All | Women | Men | P-value | |
---|---|---|---|---|
Patient demographics, characteristics and comorbidities at ICU admission | ||||
No. (%) | 8392 | 2509 (29.9) | 5883 (70.1) | |
Age, median (IQR), y | 63 (53–72) | 63 (51–72) | 63 (54–72) | 0.003 |
Age, Interval, y | ||||
< 40 | 670 (8) | 293 (11.7) | 377 (6.4) | < 0.001 |
40–49 | 900 (10.7) | 282 (11.2) | 618 (10.5) | |
50–59 | 1768 (21.1) | 483 (19.3) | 1285 (21.8) | |
60–69 | 2392 (28.5) | 651 (25.9) | 1741 (29.6) | |
70–79 | 2151 (25.6) | 646 (25.7) | 1505 (25.6) | |
≥ 80 | 511 (6.1) | 154 (6.1) | 357 (6.1) | |
Admission perioda | ||||
Wave 1 | 2428 (28.9) | 649 (25.9) | 1779 (30.2) | < 0.001 |
Wave 2 | 2104 (25.1) | 617 (24.6) | 1487 (25.3) | |
Wave 3 | 3235 (38.5) | 1021 (40.7) | 2214 (37.6) | |
Wave 4 | 625 (7.4) | 222 (8.8) | 403 (6.9) | |
Location before ICU admission | ||||
Emergency department | 1981 (23.6) | 548 (21.8) | 1433 (24.4) | 0.014 |
Hospital floor | 6409 (76.4) | 1960 (78.1) | 4449 (75.6) | |
Time from symptom to ICU admission, d | ||||
Median (IQR) | 10 (7–13) | 10 (7–12) | 10 (7–13) | < 0.001 |
Hospital level | ||||
Tertiary | 2840 (33.8) | 815 (32.5) | 2025 (34.4) | 0.068 |
County | 4349 (51.8) | 1305 (52) | 3044 (51.7) | |
Local | 1203 (14.3) | 389 (15.5) | 814 (13.8) | |
Days at hospital before ICU admission, d | ||||
No. with data | 8284 | 2464 | 5820 | |
Median (IQR) | 2 (0–4) | 2 (0–4) | 2 (0–4) | 0.570 |
Pregnant, No. (%) | 78 (0.9) | 78 (3.1) | 0 (0) | < 0.001 |
Comorbidities | ||||
None | 2527 (30.1) | 705 (28.1) | 1822 (31.0) | 0.009 |
One or more | 5865 (69.9) | 1804 (71.9) | 4061 (69.0) | 0.009 |
Chronic hypertension | 3717 (44.3) | 1039 (41.4) | 2678 (45.5) | 0.001 |
Chronic cardiac disease | 1363 (16.2) | 299 (11.9) | 1064 (18.1) | < 0.001 |
COPD/Asthma | 1464 (17.4) | 604 (24.1) | 860 (14.6) | < 0.001 |
Immune deficiency | 760 (9.1) | 300 (12.0) | 460 (7.8) | < 0.001 |
Chronic liver disease | 79 (0.9) | 29 (1.2) | 50 (0.8) | 0.228 |
Chronic kidney disease | 526 (6.3) | 152 (6.1) | 374 (6.4) | 0.640 |
Diabetes | 2102 (25.0) | 602 (24.0) | 1500 (25.5) | 0.153 |
Neuromuscular disease | 162 (1.9) | 61 (2.4) | 101 (1.7) | 0.037 |
Morbid obesityb | 702 (8.4) | 314 (12.5) | 388 (6.6) | < 0.001 |
Malignancyc, No./total (%) | 205/8284 (2.5) | 59/2464 (2.4) | 146/5820 (2.5) | 0.819 |
Treatment and vital signs at ICU admission (within 1 h before until 1 h after admission) | ||||
Vasopressor on admission, No./total (%) | 353/8284 (4.3) | 94/2464 (3.8) | 259/5820 (4.5) | 0.212 |
Feverd, No./total (%) | 2386/7876 (30.3) | 652/2340 (27.9) | 1734/5536 (31.3) | 0.002 |
Glasgow coma scale | ||||
No. with data | 3372 | 979 | 2393 | |
Median (IQR) | 15 (14–15) | 15 (14–15) | 15 (14–15) | 0.012 |
Systolic blood pressure, mmHg | ||||
No. with data | 8036 | 2382 | 5654 | |
Median (IQR) | 120 (104–140) | 120 (100–136) | 120 (105–140) | < 0.001 |
Heart rate, beats/min | ||||
No. with data | 8117 | 2410 | 5707 | |
Median (IQR) | 92 (80–109) | 93 (80–110) | 91 (80–108) | 0.204 |
PaO2, kPa | ||||
No. with data | 7637 | 2267 | 5370 | |
Median (IQR) | 8.8 (7.6–10.2) | 8.7 (7.6–10.1) | 8.8 (7.7–10.3) | 0.090 |
FiO2, % | ||||
No. with data | 5723 | 1725 | 3998 | |
Median (IQR) | 75 (60–90) | 75 (60–90) | 76 (60–90) | 0.615 |
PaO2/FiO2 ratio, kPa | ||||
No. with data | 5672 | 1710 | 3962 | |
Median (IQR) | 12.1 (9.3–16.2) | 12 (9.2–16.17) | 12.2 (9.4–16.3) | 0.329 |
White blood cell count, × 109/L | ||||
No. with data | 7622 | 2270 | 5652 | |
Median (IQR) | 9 (6.5–12.4) | 8.8 (6.3–12.4) | 9.1 (6.7–12.3) | 0.009 |
pH | ||||
No. with data | 7922 | 2352 | 5570 | |
Median (IQR) | 7.45 (7.40–7.48) | 7.44 (7.39–7.48) | 7.45 (7.4–7.48) | < 0.001 |
Creatinine, mg/dL | ||||
No. with data | 7645 | 2272 | 5373 | |
Median (IQR) | 72 (57–96) | 58 (46–79) | 77 (63–101) | < 0.001 |
Bilirubin, mg/dL | ||||
No. with data | 7393 | 2205 | 5188 | |
Median (IQR) | 9 (6–12) | 7 (5–10) | 9 (7–13) | < 0.001 |
SAPS 3 at admission, median (IQR) | ||||
No. with data | 8284 | 2464 | 5820 | |
Median (IQR) | 55 (49–62) | 55 (49–62) | 55 (49–62) | 0.313 |
Predicted risk of death, median (IQR), % | 0.26 (0.16–0.4) | 0.26 (0.16–0.4) | 0.26 (0.16–0.4) | 0.313 |