Fig. 1
From: Treatment of immunothrombosis dysregulation: high-dose corticosteroids is not the good option
Immunothrombosis refers to the interactions between innate immunity and hemostasis, and contributes to host defense against the pathogen. Sepsis-induced coagulopathy results from immunothrombosis dysregulation, leading to an excessive generation of thrombin and disseminated microthrombi. Treatment of sepsis-induced coagulopathy should depend on coagulation activation stage, although none of the presented treatment has been validated yet. New therapeutic targets (red stars) are currently being investigated and might lead to improve the management of SIC in the next years. HNE human neutrophil elastase, PMN polymorphonuclear neutrophil, MVs microvesicles, NETs neutrophil extracellular traps, tPA tissue plasminogen activator