Fig. 4From: Trends in ICU mortality and underlying risk over three decades among mechanically ventilated patients. A group level analysis of cohorts from infection prevention studiesScatter plot and linear regression of group mean age versus year of publication for groups from studies of infection prevention interventions. The linear regression line in each plot, derived using the observational groups, increased versus year of study publication (slope is + 5.4 years per decade; 95% confidence interval + 2.7 to + 7.9; p = 0.001) and serves as a benchmark for all plots [symbols; filled triangle = non-concurrent control groups; filled square  = groups receiving PPAP; open circle = all other groups; NCC groups appear as observational groups]. The same plot showing each individual group traceable to the original study is shown in Additional file 1: Fig. S5Back to article page