Table 1 Demographics, respiratory support characteristics, and hypoxemia severity
HFNO N = 229 | Ventilation N = 499 | p | |
|---|---|---|---|
Demographics | |||
Age, years (median [IQR]) | 66 [60–73] | 67 [59–73] | 0.634 |
Male gender, N (%) | 172 (75.1) | 368 (73.7) | 0.765 |
Height, cm (median [IQR]) | 175 [168–180] | 174 [168–180] | 0.624 |
Weight, kg (median [IQR]) | 85 [76–95] | 87 [78–100] | 0.063 |
BMI, kg/m2 (median [IQR]) | 28 [25–32] | 29 [26–33] | 0.042 |
SAPS II (median [IQR])* | (110/229) 31 [22–36] | (214/499) 39 [32–46] | < 0.001 |
SOFA score (median [IQR])* | (146/229) 4 [3–6] | (291/499) 6 [4–8] | < 0.001 |
Comorbidities, n (%), yes | 199 (86.9) | 426 (85.4) | 0.664 |
Arterial hypertension | 88 (38.4) | 183 (36.7) | 0.710 |
Heart failure | 61 (26.6) | 124 (24.8) | 0.672 |
Diabetes mellitus | 77 (33.6) | 148 (29.7) | 0.323 |
Chronic kidney disease | 22 (9.6) | 36 (7.2) | 0.337 |
Liver cirrhosis | 2 (0.9) | 2 (0.4) | 0.794 |
COPD | 56 (24.5) | 112 (22.4) | 0.615 |
Active hematological cancer | 6 (2.6) | 17 (3.4) | 1.000 |
Active solid cancer | 13 (5.7) | 18 (3.5) | 0.219 |
Metastatic cancer | 4 (1.7) | 5 (1.0) | 0.629 |
Neuromuscular disease | 7 (3.1) | 9 (1.8) | 0.424 |
Immunosuppression | 3 (1.3) | 15 (3.0) | 0.266 |
Respiratory Support Characteristics | < 0.001 | ||
PEEP, cm H2O (median [IQR]) | N.A | 12 [10–13] | |
Airflow, L/min (median [IQR]) | 50 [50–60] | N.A | |
FiO2 (median [IQR]) | 70 [60–85] | 50 [40–61] | |
CPAP before ICU, N (%) | 0 (0.0) | 1 (0.2) | |
NIV before ICU, N (%) | 1 (0.3) | 5 (1.0) | |
Hypoxemia severity | |||
PaO2/FiO2, mmHg (median [IQR]) | 92 [72–123] | 150 [117–188] | < 0.001 |
PaO2/FiO2 ranges | < 0.001 | ||
200–300 mmHg | 6 (2.6) | 89 (17.8) | |
100–200 mmHg | 91 (39.7) | 340 (68.1) | |
< 100 mmHg | 132 (57.6) | 70 (14.0) | |