Table 3 Univariable and multivariable models to examine the association between angiopoietin-2 (Ang-2) and extracellular water (ECW) using generalized estimating equations (GEE); the multivariable model was adjusted for chronic kidney disease, normal left ventricular ejection fraction, type of surgical procedure, duration of cardiopulmonary bypass (CPB), diuretic use, and packed red blood cell (PRBC) transfusion

Angiopoietin-2

0.242 (0.165, 0.319)

P < 0.001

0.24 (0.163, 0.317)

P < 0.001

Surgery type

 Aortic valve^#

− 1.720 (− 3.314, − 0.125)

P = 0.034

 Mitral valve^#

− 1.817 (− 3.821, 0.186)

P = 0.075

 Multivalve^#

− 3.223 (− 5.312, − 1.134)

P = 0.002

 Aortic surgery^#

− 1.644 (− 3.416, 0.129)

P = 0.069

 Left ventricular assist devices^#

0.382 (− 3.281, 4.045)

P = 0.838

 Others^#

− 4.037 (− 6.117, − 1.957)

P < 0.001

Cardiopulmonary bypass time

0.033 (0.020, 0.047)

P < 0.001

PRBC Transfusion

− 2.348 (− 3.711, − 0.985)

P = 0.001

Normal LVEF

− 2.205 (− 3.385, − 1.025)

P < 0.001

Diastolic dysfunction

0.033 (− 1.048, 1.518)

P = 0.719

Chronic kidney disease

− 1.230 (− 2.708, 0.249)

P = 0.103

Diuretic use

− 0.048 (− 1.209, 1.113)

P = 0.935