From: Sex difference in the risk of extubation failure in ICUs
Male (n = 425) | Female (n = 216) | Absolute difference % (95% CI) | P value* | |
---|---|---|---|---|
Primary outcome | ||||
Reintubation at day 7, n (%) | 71 (16.7%) | 24 (11.1%) | 5.6 (− 0.3 to 10.8) | 0.059 |
Secondary outcomes | ||||
Post-extubation respiratory failure at day 7, n (%) | 103 (24.2%) | 55 (25.4%) | − 1.2 (− 8.5 to 5.6) | 0.733 |
Cardiogenic pulmonary edema, n (%) | 19 (4.5%) | 8 (3.7%) | 0.8 (− 3.0 to 3.8) | 0.648 |
Upper airway obstruction, n (%) | 15 (3.5%) | 12 (5.5%) | − 2.0 (− 6.2 to 1.2) | 0.227 |
Reintubation among patients with post-extubation respiratory failure, n/n total (%) | 57/103 (55.3%) | 22/55 (40.0%) | 15.3 (− 1 to 30.4) | 0.066 |
Reintubation at 48 h, n (%) | 47 (11.0%) | 13 (6.0%) | 5.0 (0.2 to 9.2) | 0.038 |
Reintubation at 72 h, n (%) | 58 (13.6%) | 19 (8.7%) | 4.9 (− 0.6 to 9.6) | 0.074 |
Reintubation in ICU, n (%) | 74 (17.4%) | 26 (12.0%) | 5.4 (− 0.6 to 10.7) | 0.076 |
Patient meeting reintubation criteria in ICU, n (%) | 84 (19.8%) | 30 (13.9%) | 5.9 (− `0.4 to 11.6) | 0.066 |
Length of stay in ICU, days | 12 [7–18] | 10 [6–16] | – | 0.070 |
Length of stay in hospital, days | 16 [9–32] | 15 [8–24] | – | 0.091 |
Mortality in ICU, n (%) | 32 (7.5%) | 15 (6.9%) | 0.6 (− 4.1 to 4.6) | 0.782 |
Mortality in hospital, n (%) | 73 (17.2%) | 27 (12.5%) | 4.7 (− 1.4 to 10.1) | 0.123 |
Mortality at day-90, n (%) | 93 (21.9%) | 35 (16.2%) | 5.7 (− 0.9 to 11.7) | 0.089 |