Bedside personalized methods based on electrical impedance tomography or respiratory mechanics to set PEEP in ARDS and recruitment-to-inflation ratio: a physiologic study

Annals of Intensive Care

Table 2 Respiratory mechanics and Electrical Impedance Tomography based measurements at the optimal Positive End-Expiratory Pressure (PEEP) levels computed for each tested PEEP titration strategy

	CoV	Crossing Point	Express	Positive P_Le	ANOVA p value
PEEPtot, cmH₂O	20 [19–20]*	11 [10–12]^†	18 [16–19]*	7 [10–14]^†	< .001
Pplat, cmH₂O	31 [27–34]*	19 [17–20]^†	27 [27–28]*	18 [14–21]^†	< .001
P_Le, cmH₂O	7 [3–10]*	2 [0–3]^†	6 [3–7]*	2 [1– 2]^†	< .001
P_Li, cmH₂O	13 [10–22]*	7 [3–10]^†	12 [10–15]*	7 [5–10]^†	< .001
Pplat_L, cmH₂O	23 [16–27]*	14 [10–15]^†	19 [16–22]*	11 [8–15]^†	< .001
ΔP_RS, cmH₂O	11 [9–13]*	8 [7–10]^†	9 [8–10]*	7 [7–10]^†	< .001
C_RS, mL. cmH₂O⁻¹	41 [28–50]*	54 [43–67]^†	45 [42–56]*	59 [41–71]^†	< .001
C_L, mL. cmH₂O⁻¹	53 [34–67]*	75 [61–133]^†	63 [53–88]*	77 [58–141]†	< .001
OD, %	24 [15–29]*	9 [6–13]^†	21 [18–26]*	5 [0–14]†	< .001
LC, %	0 [0–1]*	9 [4–10]^†	1 [0–2]*	9 [2–14]†	< .001
CoV, %	53 [51–56]*	57 [53–60]^†	54 [51–57]*	56 [55–59]†	< .001
V_REC from PEEP 5 cmH₂O, mL	511 [216–785]*	232 [140–401]^†	517 [239–749]*	124 [0–155]^†*	< .001
V_REC/PBW from PEEP 5 cmH₂O, mL.kg⁻¹	7.4 [3.5–10.9]*	3.3 [2.3–4.9]^†	7.5 [3.7–10.8]*	1.5 [0.0–2.6]^†*	< .001

C_L Lung compliance, CoV Center of Ventilation, C_RS respiratory system compliance, LC Lung Collapse, OD OverDistension, PEEPtot total Positive End-Expiratory Pressure, P_Le expiratory transpulmonary pressure, P_Li inspiratory transpulmonary pressure, Pplat plateau pressure, Pplat_L plateau pressure applied to the lung, ΔP_RS respiratory system driving pressure. *Significantly different from Crossing Point method (p < 0.05), †Significantly different from CoV method (p < 0.05)