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Annals of Intensive Care

Table 3 Independent relationship between echocardiographic variables and myocardial injury

From: Association between left ventricular systolic function parameters and myocardial injury, organ failure and mortality in patients with septic shock

 

Model with LVEF

Model with s’

Model with LVLS

Model with MAPSE

Model with LV-LWFS

LVEF

aOR (CI)

0.97 (0.93–1.01)

p = 0.10

–

–

–

–

s´

aOR (CI)

–

0.93(0.76–1.16)

p = 0.53

–

–

–

LVLS

aOR (CI)

–

–

1.10 (0.98–1.24)

p = 0.11

–

–

MAPSE

aOR (CI)

–

–

 –

0.84 (0.70–0.99)

p = 0.04

 –

LV-LWFS

aOR (CI)

–

–

–

–

0.85 (0.73–0.99)

p = 0.04

Age

1.07 (1.03–1.11)

p = 0.001

1.04 (0.99–1.09)

p = 0.10

1.06 (1.01–1.10)

p = 0.01

1.06 (1.01–1.10)

p = 0.01

1.06 (1.01–1.10)

p = 0.01

Cardiac disease†

0.77 (0.31–1.91)

p = 0.58

0.76 (0.26–2.23)

p = 0.61

0.71 (0.25–1.98)

p = 0.51

0.83 (0.32–2.13)

p = 0.70

0.82 (0.32–2.11)

p = 0.68

SOFA

0.96 (0.83–1.10)

p = 0.56

0.97 (0.82–1.15)

p = 0.75

1.12 (0.95–1.33)

p = 0.19

1.00 (0.86–1.16)

p = 0.99

0.99 (0.86–1.15)

p = 0.93

SAPS 3

1.02 (0.99–1.05)

p = 0.30

1.00 (0.98–1.03)

p = 0.81

1.01 (0.97–1.04)

p = 0.67

1.03 (0.99–1.07)

p = 0.20

1.03 (0.99–1.07)

p = 0.16

Creatinine

1.00 (1.00–1.01)

p = 0.02

1.00 (1.00–1.01)

p = 0.13

1.01 (1.00–1.01)

p = 0.02

1.00 (1.00–1.01)

p = 0.02

1.00 (1.00–1.01)

p = 0.02

RV systolic dysfunction‡

1.34 (0.54–3.33)

p = 0.53

1.42 (0.43–4.66)

p = 0.56

1.45 (0.51–4.10)

p = 0.49

1.03 (0.39–2.75)

p = 0.96

1.08 (0.41–2.81)

p = 0.88

  1. Echocardiographic variables (either LVEF, s´, LVLS, MAPSE or LV-LWFS) were included in 5 separate multivariable models adjusted for age, previous cardiac disease, SOFA score, SAPS3 score, creatinine and RV systolic dysfunction. Myocardial injury defined as high-sensitivity troponin T ≥ 45 ng/L on ICU admission. Data are presented as adjusted odds ratio (aOR) (95% confidence interval)
  2. LVEF left ventricular ejection fraction. s´: peak systolic tissue Doppler velocity measured at the mitral annulus. LVLS left ventricular longitudinal strain. MAPSE mitral annular plane systolic excursion. LV-LWFS: left ventricular longitudinal wall fractional shortening. CRRT: continuous renal replacement therapy. SOFA: Sequential Organ Failure Assessment, score at admission. SAPS 3 Simplified Acute Physiology Score 3, score at admission
  3. †Pre-existing cardiac disease, defined as arrhythmias, heart failure or ischaemic heart disease, or any combination of these
  4. ‡Defined as FWS > -20%, TAPSE < 17 mm, FAC < 35%, tissue or colour s´ < 9.5 cm/s or < 6.0 cm/s, respectively, or (RV/LV) area ratio > 0.66 with concurrent paradoxical septal motion
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