Impact of direct ICU admission of pneumococcal meningitis in France: a retrospective analysis of a French medico-administrative (PMSI) database

Annals of Intensive Care

Table 3 Multivariate analysis of factors associated with death among patients admitted in ICU for pneumococcal meningitis

Variable	Multivariate analysis
Variable	Odds Ratio	95% CI	p value
Age > 65 years	1.89	[1.63; 2.2]	< 0.01
Sex (Female)	0.79	[0.68–0.92]	< 0.01
Cancer	1.26	[1.02–1.56]	0.04
Organ failures on admission
CV failure on admission	1.82	[1.52–2.17]	< 0.01
Renal failure on admission	2.31	[1.87–2.85]	< 0.01
Associated pneumonia	1.30	[1.12–1.51]	< 0.01
Mode of admission
Admission from home	2.26	[1.38–3.7]	< 0.01
Direct ICU admission	0.67	[0.56–0.8]	< 0.01
Category of 1st hospital
Regional/universitary hospital	1
Local hospital	1.24	[1.06–1.46]	0.01
Other (private hospital, short hospitalization)	1.50	[1.17–1.92]	< 0.01

Volume admissions of hospital corresponding to the volume of admissions for meningitis. The ICD-10 codes used for definitions are displayed in the Additional file 1: Table S1. The variables tested in multivariate analysis were: the variables displayed here in the Table 3 and gender (female), cardiovascular comorbidities, chronic obstructive pulmonary disease, diabetes, chronic kidney disease, neurological, respiratory and hematological failures on admission, associated diagnosis of endocarditis. The mode of admission was defined as: admission from home for patients who were directly hospitalized from home and admission from another hospital for patients hospitalized from another hospital
95% CI 95% confidence interval, CV cardiovascular, ICU intensive and intermediate care units