Table 1 Patient characteristics
From: Impact of dexamethasone in severe COVID-19-induced acute kidney injury: a multicenter cohort study
Characteristics of patients | All patients (n = 798) | No DXM (n = 331) | DXM (n = 467) | p value |
|---|---|---|---|---|
Baseline characteristics | ||||
Bordeaux, n (%) | 162 (20%) | 53 (16%) | 109 (23%) | 0.012 |
Metz-Thionville, n (%) | 636 (80%) | 278 (84%) | 358 (77%) | 0.011 |
SARS-CoV-2 variant | ||||
Wuhan, n (%) | 516 (65%) | 295 (89%) | 221 (47%) | < 0.001 |
Alpha, n (%) | 154 (19%) | 21 (6%) | 133 (28%) | |
Beta, n (%) | 104 (13%) | 15 (4%) | 89 (19%) | |
Gamma, n (%) | 2 (0.3%) | 0 (0%) | 2 (0.4%) | |
Delta, n (%) | 22 (3%) | 0 (0%) | 22 (5%) | |
Males, n (%) | 560 (70%) | 248 (78%) | 318 (68%) | 0.127 |
Age (years), mean ± SD | 63 ± 12 | 64 ± 12 | 62 ± 12 | 0.037 |
BMI (kg/m2), mean ± SD | 30.6 ± 6.6 | 30.7 ± 6.4 | 30.6 ± 6.7 | 0.88 |
Chronic kidney disease, n (%) | 46 (6%) | 22 (7%) | 24 (5%) | 0.368 |
Basal SCr (µmol/L), median [IQR] (missing values, n = 470) | 71 [59–88] | 75 [63–92] | 70 [58–84] | 0.48 |
Hypertension, n (%) | 402 (50%) | 170 (51%) | 232 (50%) | 0.64 |
Diabetes, n (%) | 231 (29%) | 91 (27%) | 140 (30%) | 0.445 |
Immunosuppression, n (%) | 39 (5%) | 15 (4%) | 24 (5%) | 0.695 |
SAPS II, median [IQR] | 35 [29–45] | 40 [29–52] | 33 [28–41] | < 0.01 |
SOFA, median [IQR] | 4 [3–6] | 5 [4–8] | 4 [3–5] | < 0.01 |
Non-renal SOFA, median [IQR] | 4 [3–5] | 3 [4–7] | 4 [3–5] | 0.05 |
Time between ICU admission and DXM administration | NA | NA | 1 [1–1] | |
ICU management | ||||
Crystalloid infusion during the first 24 h (L) | 1.7 ± 1.2 | 2.2 ± 1.4 | 1.7 ± 1.2 | < 0.001 |
Catecholamine use during the first 24 h, n (%) | 156 (19%) | 96 (29%) | 60 (12%) | < 0.001 |
Catecholamine use during ICU hospitalization, n (%) | 372 (47%) | 210 (63%) | 162 (35%) | < 0.001 |
Invasive mechanical ventilation, n (%) | 420 (53%) | 215 (70%) | 205 (43%) | < 0.001 |
Worst PaO2/FiO2, median [IQR] | 105 [74–146] | 106 [77–155] | 103 [72–138] | 0.11 |
Prone position, n (%) | 470 (59%) | 169 (51%) | 301 (64%) | < 0.001 |