Table 1 Patient characteristics

Patient characteristics

n = 28

n = 32

 Age (y), mean (± SD)

61 ± 11

63 ± 11

 Sex - male, n (%)

20(71)

22(69)

 BMI (kg/m²), mean (± SD)

31 ± 6

31 ± 6

 Comorbidities, n (%)

20(71)

26(81)

 Hypertension, n (%)

11 (39)

18(56)

 Other cardiac (Coronary heart disease, arrhythmias), n (%)

3  (11)

4  (13)

 Diabetes, n (%)

6  (21)

7 (22)

 Chronic kidney disease, n (%)

1 (4)

3  (9)

 Active cancer, n (%)

2  (7)

0(0)

 Others, n (%)

12  (43)

14(44)

Concomitant medication (at study inclusion)

 NSAID, n (%)

2  (7)

0(0)

 Antidiabetic oral, n (%)

3 (11)

4  (13)

 ACE inhibitor, n (%)

18(64)

10  (31)

 Dexamethasone, n (%)

25(89)

31(97)

Analgosedation (at study inclusion)

 Propofol, n (%)

27(96)

27(84)

 Clonidine, n (%)

1  (4)

0(0)

 Dexmedetomidine, n (%)

3 (11)

5  (16)

 Midazolam, n (%)

7  (25)

9  (28)

 Sevoflurane, n (%)

0(0)

0(0)

 Isoflurane, n (%)

0(0)

0(0)

 Ketamine, n (%)

1  (4)

0(0)

 Fentanyl, n (%)

28(100)

30(94)

 Sufentanil, n (%)

0(0)

1  (3)

 Morphine, n (%)

1 (4)

0(0)

Ventilation settings at baseline

 PEEP (cmH₂O), mean (± SD)

12 ± 2

12 ± 5

 MV (l/min), mean (± SD)

10.9 ± 2.8

9.7 ± 3.0

 PaO₂/FiO₂ (mmHg), mean (± SD)

147 ± 53

167 ± 60