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Annals of Intensive Care

Table 2 Primary and secondary outcomes

From: Influence of fluid accumulation on major adverse kidney events in critically ill patients – an observational cohort study

 

Univariable model

(unadjusted)

Multivariable model (adjusted *)

 

OR (95%-CI) /

Regression-Co-efficient B (95%-CI)

p-value

OR (95%-CI) /

Regression-Co-efficient B (95%-CI)

p-value

Primary endpoint

MAKE30

2.59 (2.25–2.99)

< 0.001

1.96 (1.67–2.30)

< 0.001

Secondary endpoints

Need for RRT

6.27 (5.18–7.60)

< 0.001

3.83 (3.02–4.84)

< 0.001

Duration of RRT on the ICU [days]

3.41 (2.06–4.76)

< 0.001

1.48 (1.14–1.82)

< 0.001

Acute kidney injury (AKI)

2.18 (1.91–2.49)

< 0.001

1.76 (1.53–2.03)

< 0.001

KDIGO stage 1

0.88 (0.75–1.03)

0.119

  

KDIGO stage 2

0.65 (0.43–0.98)

0.039

0.60 (0.39–0.91)

0.015

KDIGO stage 3

2.58 (2.28–2.92)

< 0.001

2.01 (1.76–2.31)

< 0.001

Persistent renal dysfunction+

2.54 (2.10–3.08)

< 0.001

1.72 (1.40–2.12)

< 0.001

30-day mortality

2.04 (1.69–2.45)

< 0.001

1.70 (1.38–2.09)

< 0.001

  1. Medians and interquartile range (IQR) or odds ratio (OR) and 95% confidence interval (95%-CI) or regression coefficient (95%-CI) are given. FA: fluid accumulation; MAKE30: major adverse kidney events in the first 30 days after ICU admission; RRT: renal replacement therapy; ICU: intensive care unit; AKI: acute kidney injury; KDIGO: Kidney Disease: Improving Global Outcomes
  2. + only patients without chronic dialysis before admission (n = 12,749, therof 1,012 with FA)
  3. * The multivariable regression model is adjusted for age, APACHE II Score, type of admission, creatinine at admission, history of chronic kidney disease (CKD), history of liver disease, and history of immune deficiency.Bold values represent a p-value < 0.05
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