Articles

Preclinical septic shock research: why we need an animal ICU

Animal experiments are widely used in preclinical medical research with the goal of disease modeling and exploration of novel therapeutic approaches. In the context of sepsis and septic shock, the translation ...

Authors: Antoine Guillon, Sebastien Preau, Jérôme Aboab, Eric Azabou, Boris Jung, Stein Silva, Julien Textoris, Fabrice Uhel, Dominique Vodovar, Lara Zafrani, Nicolas de Prost and Peter Radermacher

Changes in acute kidney injury epidemiology in critically ill patients: a population-based cohort study in Korea

Although no specific treatment facilitates renal tubular regeneration in acute kidney injury (AKI), the rapid increase in aging populations with more comorbidities and advances in critical care management are ...

Authors: Subin Hwang, Hyejeong Park, Youngha Kim, Danbee Kang, Ho Suk Ku, Juhee Cho, Jung Eun Lee, Wooseong Huh, Eliseo Guallar, Gee Young Suh and Hye Ryoun Jang

A multiplex analysis of sepsis mediators during human septic shock: a preliminary study on myocardial depression and organ failures

The mechanisms of organ failure during sepsis are not fully understood. The hypothesis of circulating factors has been suggested to explain septic myocardial dysfunction. We explored the biological coherence o...

Authors: Keyvan Razazi, Florence Boissier, Mathieu Surenaud, Alexandre Bedet, Aurélien Seemann, Guillaume Carteaux, Nicolas de Prost, Christian Brun-Buisson, Sophie Hue and Armand Mekontso Dessap

Sensitivity to angiotensin II dose in patients with vasodilatory shock: a prespecified analysis of the ATHOS-3 trial

Early clinical data showed that some patients with vasodilatory shock are responsive to low doses of angiotensin II. The objective of this analysis was to compare clinical outcomes in patients requiring ≤ 5 ng kg

Authors: Kealy R. Ham, David W. Boldt, Michael T. McCurdy, Laurence W. Busse, Raphael Favory, Michelle N. Gong, Ashish K. Khanna, Stefan N. Chock, Feng Zeng, Lakhmir S. Chawla, George F. Tidmarsh and Marlies Ostermann

Candidemia in critically ill immunocompromised patients: report of a retrospective multicenter cohort study

Immunocompromised critically ill patients constitute a population with the high risk of candidemia. This retrospective study aimed to assess the outcome of immunocompromised critically ill patients with candid...

Authors: Etienne Ghrenassia, Djamel Mokart, Julien Mayaux, Alexandre Demoule, Imène Rezine, Lionel Kerhuel, Laure Calvet, Audrey De Jong, Elie Azoulay and Michael Darmon

Influence of changes in ventricular systolic function and loading conditions on pulse contour analysis-derived femoral dP/dt_max

Femoral dP/dt_max (maximum rate of the arterial pressure increase during systole) measured by pulse contour analysis has been proposed as a surrogate of left ventricular (LV) dP/dt_max and as an estimator of LV sys...

Authors: Sergi Vaquer, Denis Chemla, Jean-Louis Teboul, Umar Ahmad, Flora Cipriani, Joan Carles Oliva, Ana Ochagavia, Antonio Artigas, Francisco Baigorri and Xavier Monnet

Interest and limits of assessing acute kidney injury in administrative dataset

Authors: Michaël Darmon, Emmanuel Canet and Lara Zafrani

Association between post-procedural hyperoxia and poor functional outcome after mechanical thrombectomy for ischemic stroke: an observational study

The actual effects of oxygen therapy on patients who have suffered a stroke are still unknown, and its recommendation as a routine measure in emergency services remains controversial. The aim of this study is ...

Authors: Héctor Vargas López, Miguel Fernández Vivas, Rafael Núñez Ruiz, José Ros Martínez, Blanca García-Villalba Navaridas, Manuel García Villa, Cristina Llamas Lázaro, Rubén Jara Rubio, Ana Morales Ortiz, Laura Albert Lacal and Antonio Moreno Diéguez

Effects of different ascorbic acid doses on the mortality of critically ill patients: a meta-analysis

Low levels of ascorbic acid (AA) have been detected in critically ill patients in which AA supplementation leads to promising outcomes. However, the ability of AA to reduce mortality in critically ill patients...

Authors: Ying Wang, Huan Lin, Bing-wen Lin and Jian-dong Lin

Clinical review: peripheral muscular ultrasound in the ICU

Muscular weakness developing from critical illness neuropathy, myopathy and muscle atrophy has been characterized as intensive care unit-acquired weakness (ICUAW). This entity occurs commonly during and after ...

Authors: Paolo Formenti, Michele Umbrello, Silvia Coppola, Sara Froio and Davide Chiumello

Cytokine removal in human septic shock: Where are we and where are we going?

Although improving, the mortality from septic shock still remains high despite increased international awareness. As a consequence, much effort has focused on alternative treatment strategies in an effort to i...

Authors: Patrick M. Honore, Eric Hoste, Zsolt Molnár, Rita Jacobs, Olivier Joannes-Boyau, Manu L. N. G. Malbrain and Lui G. Forni

Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study

Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respir...

Authors: Laura R. Schouten, Anton H. van Kaam, Franziska Kohse, Floor Veltkamp, Lieuwe D. Bos, Friso M. de Beer, Roosmarijn T. van Hooijdonk, Janneke Horn, Marleen Straat, Esther Witteveen, Gerie J. Glas, Luuk Wieske, Lonneke A. van Vught, Maryse A. Wiewel, Sarah A. Ingelse, Bart Cortjens…

Effects of mean arterial pressure on arousal in sedated ventilated patients with septic shock: a SEPSISPAM post hoc exploratory study

It is unknown whether the recommended mean arterial pressure (MAP) target of 65 mmHg during initial resuscitation of septic shock is sufficient to maintain cerebral perfusion. Thus, we tested the hypothesis th...

Authors: Youenn Jouan, Valérie Seegers, Ferhat Meziani, Fabien Grelon, Bruno Megarbane, Nadia Anguel, Jean-Paul Mira, Pierre-François Dequin, Soizic Gergaud, Nicolas Weiss, François Legay, Yves Le Tulzo, Marie Conrad, René Robert, Frédéric Gonzalez, Christophe Guitton…

Impact of a computer-assisted decision support system (CDSS) on nutrition management in critically ill hematology patients: the NUTCHOCO study (nutritional care in hematology oncologic patients and critical outcome)

Mortality of critically ill hematology (HM) patients has improved over time. Thus, those patients require an extensive diagnostic workup and the optimal use of available treatments. There are no data regarding...

Authors: Florence Ettori, Aurélia Henin, Christophe Zemmour, Laurent Chow-Chine, Antoine Sannini, Magali Bisbal, Frédéric Gonzalez, Luca Servan, Jean Manuel de Guibert, Marion Faucher, Jean Marie Boher and Djamel Mokart

Ventilation in patients with intra-abdominal hypertension: what every critical care physician needs to know

The incidence of intra-abdominal hypertension (IAH) is high and still underappreciated by critical care physicians throughout the world. One in four to one in three patients will have IAH on admission, while o...

Authors: Adrian Regli, Paolo Pelosi and Manu L. N. G. Malbrain

Determinants of Doppler-based renal resistive index in patients with septic shock: impact of hemodynamic parameters, acute kidney injury and predisposing factors

Increased renal resistive index (RI) measured by Doppler ultrasonography has been shown to be associated with acute kidney injury (AKI) in septic patients. However, its clinical use is limited by poor sensitiv...

Authors: François Beloncle, Natacha Rousseau, Jean-François Hamel, Alexis Donzeau, Anne-Lise Foucher, Marc-Antoine Custaud, Pierre Asfar, René Robert and Nicolas Lerolle

Diaphragm thickening in cardiac surgery: a perioperative prospective ultrasound study

Diaphragm paresis is common after cardiac surgery and may delay the weaning from the ventilator. Our objective was to evaluate diaphragm thickening during weaning and secondly the muscle thickness as a marker ...

Authors: Pierre-Henri Moury, Adrien Cuisinier, Michel Durand, Jean-Luc Bosson, Olivier Chavanon, Jean-François Payen, Samir Jaber and Pierre Albaladejo

A clinical evaluation of two central venous catheter stabilization systems

Central venous catheters (CVCs) are commonly secured with sutures which are associated with microbial colonization and infection. We report a comparison of a suture-free system with standard sutures for securi...

Authors: Tarja J. Karpanen, Anna L. Casey, Tony Whitehouse, Jean-Francois Timsit, Olivier Mimoz, Mercedes Palomar and Tom S. J. Elliott

Determinants of left ventricular ejection fraction and a novel method to improve its assessment of myocardial contractility

The aim of this study was to quantify the impact of different cardiovascular factors on left ventricular ejection fraction (LVEF) and test a novel LVEF calculation considering these factors.

Authors: Manuel Ignacio Monge García, Zhongping Jian, Jos J. Settels, Charles Hunley, Maurizio Cecconi, Feras Hatib and Michael R. Pinsky

Update in Neurocritical Care: a summary of the 2018 Paris international conference of the French Society of Intensive Care

The 2018 Paris Intensive Care symposium entitled “Update in Neurocritical Care” was organized in Paris, June 21–22, 2018, under the auspices of the French Intensive Care Society. This 2-day post-graduate educa...

Authors: Mauro Oddo, Serge Bracard, Alain Cariou, Gérald Chanques, Giuseppe Citerio, Béatrix Clerckx, Bertrand Godeau, Anne Godier, Janneke Horn, Samir Jaber, Boris Jung, Khaldoun Kuteifan, Marc Leone, Alexandra Mailles, Mikael Mazighi, Bruno Mégarbane…

Predictive analytics: beyond the buzz

Authors: Frederic Michard and Jean Louis Teboul

Risk factors for progression toward brain death after out-of-hospital cardiac arrest

Successfully resuscitated out-of-hospital cardiac arrest (OHCA) may lead to brain death (BD) and good-quality transplantable organs. We aimed to determine risk factors for evolution toward BD after OHCA. We an...

Authors: Martin Cour, Jean Turc, Thomas Madelaine and Laurent Argaud

Airway pressure release ventilation during acute hypoxemic respiratory failure: a systematic review and meta-analysis of randomized controlled trials

Airway pressure release ventilation (APRV) has been considered a tempting mode of ventilation during acute respiratory failure within the concept of open lung ventilation. We performed a systematic review and ...

Authors: Andrea Carsetti, Elisa Damiani, Roberta Domizi, Claudia Scorcella, Simona Pantanetti, Stefano Falcetta, Abele Donati and Erica Adrario

Proceedings of Réanimation 2019, the French Intensive Care Society International Congress

Authors:

Gender and survival of critically ill patients: results from the FROG-ICU study

Few studies analyzed gender-related outcome differences of critically ill patients and found inconsistent results. This study aimed to test the independent association of gender and long-term survival of ICU p...

Authors: Alexa Hollinger, Etienne Gayat, Elodie Féliot, Catherine Paugam-Burtz, Marie-Céline Fournier, Jacques Duranteau, Jean-Yves Lefrant, Marc Leone, Samir Jaber, Alexandre Mebazaa and Mattia Arrigo

Chest CT scan and alveolar procollagen III to predict lung fibroproliferation in acute respiratory distress syndrome

Lung fibroproliferation in ARDS patients is associated with mortality. Alveolar procollagen III (NT-PCP-III) is a validated biomarker of lung fibroproliferation. A chest CT scan could be useful for the diagnos...

Authors: Annabelle Hamon, Ugo Scemama, Jérémy Bourenne, Florence Daviet, Benjamin Coiffard, Nicolas Persico, Mélanie Adda, Christophe Guervilly, Sami Hraiech, Kathia Chaumoitre, Antoine Roch, Laurent Papazian and Jean-Marie Forel

Does volatile sedation with sevoflurane allow spontaneous breathing during prolonged prone positioning in intubated ARDS patients? A retrospective observational feasibility trial

Lung-protective ventilation and prolonged prone positioning (PP) are presented as essential in treating acute respiratory distress syndrome (ARDS). The optimal respirator mode, however, remains controversial. ...

Authors: Jascha Heider, Joachim Bansbach, Kai Kaufmann, Sebastian Heinrich, Torsten Loop and Johannes Kalbhenn

Pulmonary infections prime the development of subsequent ICU-acquired pneumonia in septic shock

To investigate the determinants and the prognosis of intensive care unit (ICU)-acquired pneumonia in patients with septic shock.

Authors: Jean-François Llitjos, Aïcha Gassama, Julien Charpentier, Jérôme Lambert, Charles de Roquetaillade, Alain Cariou, Jean-Daniel Chiche, Jean-Paul Mira, Matthieu Jamme and Frédéric Pène

Associations between tricuspid annular plane systolic excursion to reflect right ventricular function and acute kidney injury in critically ill patients: a SICS-I sub-study

Acute kidney injury (AKI) occurs in up to 50% of all critically ill patients and hemodynamic abnormalities are assumed to contribute, but their nature and share is still unclear. We explored the associations b...

Authors: Renske Wiersema, Jacqueline Koeze, Bart Hiemstra, Ville Pettilä, Anders Perner, Frederik Keus and Iwan C. C. van der Horst

Narrative review: clinical assessment of peripheral tissue perfusion in septic shock

Sepsis is one of the main reasons for intensive care unit admission and is responsible for high morbidity and mortality. The usual hemodynamic targets for resuscitation of patients with septic shock use macro-...

Authors: Geoffroy Hariri, Jérémie Joffre, Guillaume Leblanc, Michael Bonsey, Jean-Remi Lavillegrand, Tomas Urbina, Bertrand Guidet, Eric Maury, Jan Bakker and Hafid Ait-Oufella

Correction to: Risk factors for mortality in elderly and very elderly critically ill patients with sepsis: a prospective, observational, multicenter cohort study

Following the publication of the original article [1], the author reported a mistake in Fig. 1.

Authors: Ignacio Martin-Loeches, Maria Consuelo Guia, Maria Sole Vallecoccia, David Suarez, Mercedes Ibarz, Marian Irazabal, Ricard Ferrer and Antonio Artigas

Eliminating endotoxin by polymyxin B hemoperfusion and/or continuous renal replacement therapy: should the focus be on timing, dosing, and type of renal epuration?

Authors: Patrick M. Honore, David De Bels, Sebastien Redant and Herbert D. Spapen

Response to the letter to the Editor “Comparing video and direct laryngoscopy for tracheal intubation in the general ward” by Shao and Colleagues

Authors: Moon Seong Baek, MyongJa Han, Jin Won Huh, Chae-Man Lim, Younsuck Koh and Sang-Bum Hong

Correction to: Effects of the timing of administration of IgM- and IgA-enriched intravenous polyclonal immunoglobulins on the outcome of septic shock patients

Following publication of the original article [1], we have been notified that the tagging of the author name was done incorrectly in the XML version of the paper. The correct given name is Michele Claudio, and...

Authors: Giorgio Berlot, Michele Claudio Vassallo, Nicola Busetto, Margarita Nieto Yabar, Tatiana Istrati, Silvia Baronio, Giada Quarantotto, Mattia Bixio, Giulia Barbati, Roberto Dattola, Irene Longo, Antonino Chillemi, Alice Scamperle, Fulvio Iscra and Ariella Tomasini

Management of hyperkalemia in the acutely ill patient

To review the mechanisms of action, expected efficacy and side effects of strategies to control hyperkalemia in acutely ill patients.

Authors: François Dépret, W. Frank Peacock, Kathleen D. Liu, Zubaid Rafique, Patrick Rossignol and Matthieu Legrand

Invasive pulmonary aspergillosis in cirrhotic patients: analysis of a 10-year clinical experience

Cirrhosis is not recognised as one of the main risk factors of invasive pulmonary aspergillosis (IPA), although its prevalence is increasing. The aim of our study was to identify factors for IPA in such patien...

Authors: Eric Levesque, Nawel Ait-Ammar, Daniela Dudau, Noémie Clavieras, Cyrille Feray, Françoise Foulet and Françoise Botterel

Effects of chloride content of intravenous crystalloid solutions in critically ill adult patients: a meta-analysis with trial sequential analysis of randomized trials

Intravenous crystalloid solutions are administered commonly for critically ill patients. We performed this meta-analysis of randomized trials with trial sequential analysis (TSA) to evaluate effects of chlorid...

Authors: Ming Xue, Xiwen Zhang, Feng Liu, Wei Chang, Jianfeng Xie, Jingyuan Xu, Yi Yang and Haibo Qiu

The association of intravenous insulin and glucose infusion with intensive care unit and hospital mortality: a retrospective study

We assessed the association of intravenous insulin and glucose infusion with intensive care unit (ICU) and hospital mortality.

Authors: Sigrid C. van Steen, Saskia Rijkenberg, Peter H. J. van der Voort and J. Hans DeVries

Renal protection in sepsis: Is hypertonic sodium (lactate) the solution?

Authors: Patrick M. Honore, Leonel Barreto Gutierrez and Herbert D. Spapen

The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Sepsis is characterized by a complex immune response. This meta-analysis evaluated the clinical effectiveness of intravenous IgM-enriched immunoglobulin (IVIgGM) in patients with sepsis and septic shock.

Authors: Jie Cui, Xuxia Wei, Haijin Lv, Yuntao Li, Ping Li, Zhen Chen and Genglong Liu

Risk factors for mortality in elderly and very elderly critically ill patients with sepsis: a prospective, observational, multicenter cohort study

Age has been traditionally considered a risk factor for mortality in elderly patients admitted to intensive care units. The aim of this prospective, observational, multicenter cohort study is to determine the ...

Authors: Ignacio Martin-Loeches, Maria Consuelo Guia, Maria Sole Vallecoccia, David Suarez, Mercedes Ibarz, Marian Irazabal, Ricard Ferrer and Antonio Artigas

Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know?

Checkpoint protein inhibitor antibodies (CPI), including cytotoxic T-lymphocyte-associated antigen 4 inhibitors (ipilimumab, tremelimumab) and the programmed cell death protein 1 pathway/programmed cell death ...

Authors: Virginie Lemiale, Anne-Pascale Meert, François Vincent, Michael Darmon, Philippe R. Bauer, Andry Van de Louw and Elie Azoulay

Impact of levosimendan on weaning from peripheral venoarterial extracorporeal membrane oxygenation in intensive care unit

Few data are available on the impact of levosimendan in refractory cardiogenic shock patients undergoing peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO). The aim of this study was to eval...

Authors: Shamir Vally, Cyril Ferdynus, Romain Persichini, Bruno Bouchet, Eric Braunberger, Hugo Lo Pinto, Olivier Martinet, David Vandroux, Thomas Aujoulat, Jérôme Allyn and Nicolas Allou

Factors associated with renal Doppler resistive index in critically ill patients: a prospective cohort study

The renal Doppler resistive index (renal RI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. However, many parameters have been described as influen...

Authors: Raphael A. G. Oliveira, Pedro V. Mendes, Marcelo Park and Leandro U. Taniguchi

Hemoadsorption therapy in the critically ill: solid base but clinical haze

Authors: Patrick M. Honoré, David De Bels, Leonel Barreto Gutierrez and Herbert D. Spapen

Comparing video and direct laryngoscopy for tracheal intubation in the general ward

Authors: Liu-Jia-Zi Shao, Fu-Shan Xue, Rui-Juan Guo and He Yang

Current use of vasopressors in septic shock

Vasopressors are commonly applied to restore and maintain blood pressure in patients with sepsis. We aimed to evaluate the current practice and therapeutic goals regarding vasopressor use in septic shock as a ...

Authors: Thomas W. L. Scheeren, Jan Bakker, Daniel De Backer, Djillali Annane, Pierre Asfar, E. Christiaan Boerma, Maurizio Cecconi, Arnaldo Dubin, Martin W. Dünser, Jacques Duranteau, Anthony C. Gordon, Olfa Hamzaoui, Glenn Hernández, Marc Leone, Bruno Levy, Claude Martin…

Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study

Septic coagulopathy represents a very dynamic disease entity, tilting from initial hypercoagulability towards a subsequent hypocoagulable disease state, entitled overt disseminated intravascular coagulation. A...

Authors: Felix Carl Fabian Schmitt, Vasil Manolov, Jakob Morgenstern, Thomas Fleming, Stefan Heitmeier, Florian Uhle, Mohammed Al-Saeedi, Thilo Hackert, Thomas Bruckner, Herbert Schöchl, Markus Alexander Weigand, Stefan Hofer and Thorsten Brenner

The prognostic accuracy evaluation of SAPS 3, SOFA and APACHE II scores for mortality prediction in the surgical ICU: an external validation study and decision-making analysis

The early postoperative period is critical for surgical patients. SOFA, SAPS 3 and APACHE II are prognostic scores widely used to predict mortality in ICU patients. This study aimed to evaluate these index tes...

Authors: Antônio Luis Eiras Falcão, Alexandre Guimarães de Almeida Barros, Angela Alcântara Magnani Bezerra, Natália Lopes Ferreira, Claudinéia Muterle Logato, Filipa Pais Silva, Ana Beatriz Francioso Oliveira do Monte, Rodrigo Marques Tonella, Luciana Castilho de Figueiredo, Rui Moreno, Desanka Dragosavac and Nelson Adami Andreollo

Infectious complications following heart transplantation in the era of high-priority allocation and extracorporeal membrane oxygenation

Infectious complications are a major cause of morbidity and mortality after heart transplantation (HT). However, the epidemiology and outcomes of these infections in the recent population of adult heart transp...

Authors: Stéphanie Pons, Romain Sonneville, Lila Bouadma, Lenka Styfalova, Stéphane Ruckly, Mathilde Neuville, Aguila Radjou, Jordane Lebut, Marie-Pierre Dilly, Bruno Mourvillier, Richard Dorent, Patrick Nataf, Michel Wolff and Jean-François Timsit