Articles

Renal protection in sepsis: Is hypertonic sodium (lactate) the solution?

Authors: Patrick M. Honore, Leonel Barreto Gutierrez and Herbert D. Spapen

The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis

Sepsis is characterized by a complex immune response. This meta-analysis evaluated the clinical effectiveness of intravenous IgM-enriched immunoglobulin (IVIgGM) in patients with sepsis and septic shock.

Authors: Jie Cui, Xuxia Wei, Haijin Lv, Yuntao Li, Ping Li, Zhen Chen and Genglong Liu

Risk factors for mortality in elderly and very elderly critically ill patients with sepsis: a prospective, observational, multicenter cohort study

Age has been traditionally considered a risk factor for mortality in elderly patients admitted to intensive care units. The aim of this prospective, observational, multicenter cohort study is to determine the ...

Authors: Ignacio Martin-Loeches, Maria Consuelo Guia, Maria Sole Vallecoccia, David Suarez, Mercedes Ibarz, Marian Irazabal, Ricard Ferrer and Antonio Artigas

Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know?

Checkpoint protein inhibitor antibodies (CPI), including cytotoxic T-lymphocyte-associated antigen 4 inhibitors (ipilimumab, tremelimumab) and the programmed cell death protein 1 pathway/programmed cell death ...

Authors: Virginie Lemiale, Anne-Pascale Meert, François Vincent, Michael Darmon, Philippe R. Bauer, Andry Van de Louw and Elie Azoulay

Impact of levosimendan on weaning from peripheral venoarterial extracorporeal membrane oxygenation in intensive care unit

Few data are available on the impact of levosimendan in refractory cardiogenic shock patients undergoing peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO). The aim of this study was to eval...

Authors: Shamir Vally, Cyril Ferdynus, Romain Persichini, Bruno Bouchet, Eric Braunberger, Hugo Lo Pinto, Olivier Martinet, David Vandroux, Thomas Aujoulat, Jérôme Allyn and Nicolas Allou

Factors associated with renal Doppler resistive index in critically ill patients: a prospective cohort study

The renal Doppler resistive index (renal RI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. However, many parameters have been described as influen...

Authors: Raphael A. G. Oliveira, Pedro V. Mendes, Marcelo Park and Leandro U. Taniguchi

Hemoadsorption therapy in the critically ill: solid base but clinical haze

Authors: Patrick M. Honoré, David De Bels, Leonel Barreto Gutierrez and Herbert D. Spapen

Comparing video and direct laryngoscopy for tracheal intubation in the general ward

Authors: Liu-Jia-Zi Shao, Fu-Shan Xue, Rui-Juan Guo and He Yang

Current use of vasopressors in septic shock

Vasopressors are commonly applied to restore and maintain blood pressure in patients with sepsis. We aimed to evaluate the current practice and therapeutic goals regarding vasopressor use in septic shock as a ...

Authors: Thomas W. L. Scheeren, Jan Bakker, Daniel De Backer, Djillali Annane, Pierre Asfar, E. Christiaan Boerma, Maurizio Cecconi, Arnaldo Dubin, Martin W. Dünser, Jacques Duranteau, Anthony C. Gordon, Olfa Hamzaoui, Glenn Hernández, Marc Leone, Bruno Levy, Claude Martin…

Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study

Septic coagulopathy represents a very dynamic disease entity, tilting from initial hypercoagulability towards a subsequent hypocoagulable disease state, entitled overt disseminated intravascular coagulation. A...

Authors: Felix Carl Fabian Schmitt, Vasil Manolov, Jakob Morgenstern, Thomas Fleming, Stefan Heitmeier, Florian Uhle, Mohammed Al-Saeedi, Thilo Hackert, Thomas Bruckner, Herbert Schöchl, Markus Alexander Weigand, Stefan Hofer and Thorsten Brenner

The prognostic accuracy evaluation of SAPS 3, SOFA and APACHE II scores for mortality prediction in the surgical ICU: an external validation study and decision-making analysis

The early postoperative period is critical for surgical patients. SOFA, SAPS 3 and APACHE II are prognostic scores widely used to predict mortality in ICU patients. This study aimed to evaluate these index tes...

Authors: Antônio Luis Eiras Falcão, Alexandre Guimarães de Almeida Barros, Angela Alcântara Magnani Bezerra, Natália Lopes Ferreira, Claudinéia Muterle Logato, Filipa Pais Silva, Ana Beatriz Francioso Oliveira do Monte, Rodrigo Marques Tonella, Luciana Castilho de Figueiredo, Rui Moreno, Desanka Dragosavac and Nelson Adami Andreollo

Infectious complications following heart transplantation in the era of high-priority allocation and extracorporeal membrane oxygenation

Infectious complications are a major cause of morbidity and mortality after heart transplantation (HT). However, the epidemiology and outcomes of these infections in the recent population of adult heart transp...

Authors: Stéphanie Pons, Romain Sonneville, Lila Bouadma, Lenka Styfalova, Stéphane Ruckly, Mathilde Neuville, Aguila Radjou, Jordane Lebut, Marie-Pierre Dilly, Bruno Mourvillier, Richard Dorent, Patrick Nataf, Michel Wolff and Jean-François Timsit

Concurrent initiation of intra-aortic balloon pumping with extracorporeal membrane oxygenation reduced in-hospital mortality in postcardiotomy cardiogenic shock

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is widely used in postcardiotomy cardiac shock (PCS). The factors that affect mortality in patients who receive ECMO for PCS remain unclear. In this ...

Authors: Kai Chen, Jianfeng Hou, Hanwei Tang and Shengshou Hu

NUTRI-REAPED study: nutritional assessment of French critically ill children and nutrition practice survey in French-speaking pediatric intensive care units

Impaired nutritional status is adversely associated with suboptimal outcomes in critically ill children. Undernutrition at pediatric intensive care unit (PICU) admission ranges from 15 to 65%. A lack of knowle...

Authors: Aurélien Jacquot, Frédéric Victor Valla, Thibault Mura, Lyvonne Nicole Tume, Héléna Bertet, Carole Ford-Chessel, Christophe Milesi, Gilles Cambonie, Arnaud De Luca and Bénédicte Gaillard-Le Roux

Admission to the intensive care unit: the need to study complexity and solutions

Authors: Ashraf Roshdy

Experts’ guidelines of intubation and extubation of the ICU patient of French Society of Anaesthesia and Intensive Care Medicine (SFAR) and French-speaking Intensive Care Society (SRLF)

Intubation and extubation of ventilated patients are not risk-free procedures in the intensive care unit (ICU) and can be associated with morbidity and mortality. Intubation in the ICU is frequently required i...

Authors: Hervé Quintard, Erwan l’Her, Julien Pottecher, Frédéric Adnet, Jean-Michel Constantin, Audrey De Jong, Pierre Diemunsch, Rose Fesseau, Anne Freynet, Christophe Girault, Christophe Guitton, Yann Hamonic, Eric Maury, Armand Mekontso-Dessap, Fabrice Michel, Paul Nolent…

Lung recruitment: What has computed tomography taught us in the last decade?

Although chest X-ray remains a fundamental lung imaging technique, through the years, CT scan has significantly improved our knowledge of the pathophysiological process and currently is the reference lung imag...

Authors: D. Chiumello, P. Formenti and S. Coppola

Photoplethysmographic determination of the respiratory rate in acutely ill patients: validation of a new algorithm and implementation into a biomedical device

Respiratory rate is among the first vital signs to change in deteriorating patients. The aims of this study were to evaluate the accuracy of respiratory rate measurements using a specifically dedicated reflect...

Authors: Erwan L’Her, Quang-Thang N’Guyen, Victoire Pateau, Laetitia Bodenes and François Lellouche

Correction to: Hypoxemia in the ICU: prevalence, treatment, and outcome

Following publication of the original article [1], we have been notified that only the 11 members of the writing committee are listed as the collaborators of the SRLF Trial group

Authors:

Feasibility of an alternative, physiologic, individualized open-lung approach to high-frequency oscillatory ventilation in children

High-frequency oscillatory ventilation (HFOV) is a common but unproven management strategy in paediatric critical care. Oscillator settings have been traditionally guided by patient age and/or weight rather th...

Authors: Pauline de Jager, Tamara Kamp, Sandra K. Dijkstra, Johannes G. M. Burgerhof, Dick G. Markhorst, Martha A. Q. Curley, Ira M. Cheifetz and Martin C. J. Kneyber

Effect of preadmission glucocorticoid therapy on 30-day mortality in critically ill patients: a retrospective study of a mixed ICU population in a tertiary hospital

This study aimed to investigate the association between preadmission glucocorticoid (GC) therapy and 30-day mortality in critically ill patients following admission to an intensive care unit (ICU). We aimed to...

Authors: Tak Kyu Oh, In-Ae Song, Jae Ho Lee, Cheong Lim, Young-Tae Jeon, Hee-Joon Bae and You Hwan Jo

Positive end-expiratory pressure titration with electrical impedance tomography and pressure–volume curve in severe acute respiratory distress syndrome

The study objective was to compare titration of positive end-expiratory pressure (PEEP) with electrical impedance tomography (EIT) and with ventilator-embedded pressure–volume loop in severe acute respiratory ...

Authors: Zhanqi Zhao, Mei-Ying Chang, Mei-Yun Chang, Chien-Hung Gow, Jia-Hao Zhang, Yeong-Long Hsu, Inez Frerichs, Hou-Tai Chang and Knut Möller

Weaning failure of cardiovascular origin: how to suspect, detect and treat—a review of the literature

Among the multiple causes of weaning failure from mechanical ventilation, cardiovascular dysfunction is increasingly recognized as a quite frequent cause that can be treated successfully. In this review, we su...

Authors: Christina Routsi, Ioannis Stanopoulos, Stelios Kokkoris, Antonios Sideris and Spyros Zakynthinos

Comparison of the accuracy of neutrophil CD64, procalcitonin, and C-reactive protein for sepsis identification: a systematic review and meta-analysis

Neutrophil CD64 is widely described as an accurate biomarker for the diagnosis of infection in patients with septic syndrome. We performed a systematic review and meta-analysis to evaluate the diagnostic accur...

Authors: Chun-Fu Yeh, Chin-Chieh Wu, Su-Hsun Liu and Kuan-Fu Chen

High-flow oxygen therapy in tracheostomized patients at high risk of weaning failure

High-flow oxygen therapy delivered through nasal cannulae improves oxygenation and decreases work of breathing in critically ill patients. Little is known of the physiological effects of high-flow oxygen thera...

Authors: Tania Stripoli, Savino Spadaro, Rosa Di mussi, Carlo Alberto Volta, Paolo Trerotoli, Francesca De Carlo, Rachele Iannuzziello, Fabio Sechi, Paola Pierucci, Francesco Staffieri, Francesco Bruno, Luigi Camporota and Salvatore Grasso

Low-flow CO₂ removal in combination with renal replacement therapy effectively reduces ventilation requirements in hypercapnic patients: a pilot study

Lung-protective strategies are the cornerstone of mechanical ventilation in critically ill patients with both ARDS and other disorders. Extracorporeal CO₂ removal (ECCO₂R) may enhance lung protection by allowing ...

Authors: Jens Nentwich, Dominic Wichmann, Stefan Kluge, Simone Lindau, Haitham Mutlak and Stefan John

Long-term health-related quality of life of critically ill patients with haematological malignancies: a prospective observational multicenter study

Although outcomes of critically ill patients with haematological malignancies (HMs) have been fully investigated in terms of organ failure and mortality, data are scarce on health-related quality of life (HRQO...

Authors: Franck Ehooman, Lucie Biard, Virginie Lemiale, Damien Contou, Nicolas de Prost, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, Alexandre Demoule, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez…

Driving pressure during proportional assist ventilation: an observational study

During passive mechanical ventilation, the driving pressure of the respiratory system is an important mediator of ventilator-induced lung injury. Monitoring of driving pressure during assisted ventilation, sim...

Authors: Katerina Vaporidi, Charalambos Psarologakis, Athanasia Proklou, Emmanouil Pediaditis, Evangelia Akoumianaki, Elisavet Koutsiana, Achilleas Chytas, Ioanna Chouvarda, Eumorfia Kondili and Dimitris Georgopoulos

Ischemic and hemorrhagic brain injury during venoarterial-extracorporeal membrane oxygenation

Structural neurological complications (ischemic stroke and intracranial bleeding) and their risk factors in patients receiving venoarterial-extracorporeal membrane oxygenation (VA-ECMO) are poorly described. O...

Authors: Loïc Le Guennec, Clémentine Cholet, Florent Huang, Matthieu Schmidt, Nicolas Bréchot, Guillaume Hékimian, Sébastien Besset, Guillaume Lebreton, Ania Nieszkowska, Pascal Leprince, Alain Combes and Charles-Edouard Luyt

Nasal high-flow bronchodilator nebulization: a randomized cross-over study

There is an absence of controlled clinical data showing bronchodilation effectiveness after nebulization via nasal high-flow therapy circuits.

Authors: François Reminiac, Laurent Vecellio, Laetitia Bodet-Contentin, Valérie Gissot, Deborah Le Pennec, Charlotte Salmon Gandonnière, Maria Cabrera, Pierre-François Dequin, Laurent Plantier and Stephan Ehrmann

ICU survival and need of renal replacement therapy with respect to AKI duration in critically ill patients

Transient and persistent acute kidney injury (AKI) could share similar physiopathological mechanisms. The objective of our study was to assess prognostic impact of AKI duration on ICU mortality.

Authors: A. S. Truche, S. Perinel Ragey, B. Souweine, S. Bailly, L. Zafrani, L. Bouadma, C. Clec’h, M. Garrouste-Orgeas, G. Lacave, C. Schwebel, F. Guebre-Egziabher, C. Adrie, A. S. Dumenil, Ph. Zaoui, L. Argaud, S. Jamali…

Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study

The clinical interest of using bubble humidification of oxygen remains controversial. This study was designed to further explore whether delivering dry oxygen instead of bubble-moistened oxygen had an impact o...

Authors: Laurent Poiroux, Lise Piquilloud, Valérie Seegers, Cyril Le Roy, Karine Colonval, Carole Agasse, Vanessa Zinzoni, Vanessa Hodebert, Alexandre Cambonie, Josselin Saletes, Irma Bourgeon, François Beloncle and Alain Mercat

Lung ultrasound estimation of pleural effusion fluid and the importance of patient position

Authors: Luigi Vetrugno and Tiziana Bove

Impact of individualized target mean arterial pressure for septic shock resuscitation on the incidence of acute kidney injury: a retrospective cohort study

To examine the relationship between delta mean arterial pressure (ΔMAP; MAP change between pre-admission minus post-resuscitation) and acute kidney injury (AKI) among patients with septic shock. In this retros...

Authors: Rajat N. Moman, Stuart A. Ostby, Abbasali Akhoundi, Rahul Kashyap and Kianoush Kashani

Proportional modes versus pressure support ventilation: a systematic review and meta-analysis

Proportional modes (proportional assist ventilation, PAV, and neurally adjusted ventilatory assist, NAVA) could improve patient–ventilator interaction and consequently may be efficient as a weaning mode. The p...

Authors: Jun Kataoka, Akira Kuriyama, Yasuhiro Norisue and Shigeki Fujitani

Effects of the timing of administration of IgM- and IgA-enriched intravenous polyclonal immunoglobulins on the outcome of septic shock patients

The administration of endovenous immunoglobulins in patients with septic shock could be beneficial and preparations enriched with IgA and IgM (ivIgGAM) seem to be more effective than those containing only IgG....

Authors: Giorgio Berlot, Michele Claudio Vassallo, Nicola Busetto, Margarita Nieto Yabar, Tatiana Istrati, Silvia Baronio, Giada Quarantotto, Mattia Bixio, Giulia Barbati, Roberto Dattola, Irene Longo, Antonino Chillemi, Alice Scamperle, Fulvio Iscra and Ariella Tomasini

Impact of hemoperfusion with polymyxin B added to hemofiltration in patients with endotoxic shock: a case–control study

Septic shock is a leading cause of death in critical patients. In patients with gram-negative septic shock, hemoperfusion with polymyxin B aims to remove endotoxins from plasma. We analyzed the clinical and bi...

Authors: Ana Navas, Ricard Ferrer, Maria Luisa Martínez, Gemma Gomà, Gisela Gili, Jordi Masip, David Suárez and Antonio Artigas

Hemodynamic effects of extended prone position sessions in ARDS

Hemodynamic response to prone position (PP) has never been studied in a large series of patients with acute respiratory distress syndrome (ARDS). The primary aim of this study was to estimate the rate of PP se...

Authors: Martin Ruste, Laurent Bitker, Hodane Yonis, Zakaria Riad, Aurore Louf-Durier, Floriane Lissonde, Sophie Perinel-Ragey, Claude Guerin and Jean-Christophe Richard

Driving pressure and long-term outcomes in moderate/severe acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) patients may present impaired in lung function and structure after hospital discharge that may be related to mechanical ventilation strategy. The aim of this study wa...

Authors: Carlos Toufen Junior, Roberta R. De Santis Santiago, Adriana S. Hirota, Alysson Roncally S. Carvalho, Susimeire Gomes, Marcelo Brito Passos Amato and Carlos Roberto Ribeiro Carvalho

Melatonin and cortisol exhibit different circadian rhythm profiles during septic shock depending on timing of onset: a prospective observational study

Septic shock has been found to disrupt circadian rhythms. Moreover, timing of onset has been associated with different circadian profiles in experimental studies.

Authors: Eleni N. Sertaridou, Ioanna G. Chouvarda, Konstantinos I. Arvanitidis, Eirini K. Filidou, George C. Kolios, Ioannis N. Pnevmatikos and Vasilios E. Papaioannou

Evaluation of emotional excitation during standardized endotracheal intubation in simulated conditions

To assess how stressful conditions in endotracheal intubation could induct emotional excitation in a population of acute care physicians.

Authors: Nicolas S. Marjanovic, Christelle Teiten, Nicola Pallamin and Erwan L’Her

Defending a mean arterial pressure in the intensive care unit: Are we there yet?

Authors: Ashish K. Khanna

Validation of a new WIND classification compared to ICC classification for weaning outcome

Although the WIND (Weaning according to a New Definition) classification based on duration of ventilation after the first separation attempt has been proposed, this new classification has not been tested in cl...

Authors: Byeong-Ho Jeong, Kyeong Yoon Lee, Jimyoung Nam, Myeong Gyun Ko, Soo Jin Na, Gee Young Suh and Kyeongman Jeon

Caring for the critically ill patients over 80: a narrative review

There is currently no international recommendation for the admission or treatment of the critically ill older patients over 80 years of age in the intensive care unit (ICU), and there is no valid prognostic se...

Authors: Bertrand Guidet, Helene Vallet, Jacques Boddaert, Dylan W. de Lange, Alessandro Morandi, Guillaume Leblanc, Antonio Artigas and Hans Flaatten

Sustained low efficiency dialysis should not be interrupted for performing transpulmonary thermodilution measurements

Treatment of multiple organ failure frequently requires enhanced hemodynamic monitoring. When renal replacement is indicated, it remains unclear whether transpulmonary thermodilution (TPTD) measurements are in...

Authors: Stefanie Geith, Lynne Stecher, Christian Rabe, Stefan Sack and Florian Eyer

Development and performance of a novel vasopressor-driven mortality prediction model in septic shock

Vasoactive medications are essential in septic shock, but are not fully incorporated into current mortality prediction risk scores. We sought to develop a novel mortality prediction model for septic shock inco...

Authors: Saraschandra Vallabhajosyula, Jacob C. Jentzer, Aditya A. Kotecha, Dennis H. Murphree Jr., Erin F. Barreto, Ashish K. Khanna and Vivek N. Iyer

Inflammatory and coagulatory parameters linked to survival in critically ill children with sepsis

Sepsis is associated with a deflection of inflammatory and coagulative parameters, since some clotting factors are known to be involved in the host’s defense against infection and inflammation. These parameter...

Authors: Christian Niederwanger, Mirjam Bachler, Tobias Hell, Caroline Linhart, Andreas Entenmann, Agnes Balog, Katharina Auer and Petra Innerhofer

Lung aeration and ventilation after percutaneous tracheotomy measured by electrical impedance tomography in non-hypoxemic critically ill patients: a prospective observational study

Percutaneous dilatational tracheotomy (PDT) may lead to transient impairment of pulmonary function due to suboptimal ventilation, loss of positive end-expiratory pressure (PEEP) and repetitive suction maneuver...

Authors: Lars Eichler, Jakob Mueller, Jörn Grensemann, Inez Frerichs, Christian Zöllner and Stefan Kluge

Artificial liver support systems: what is new over the last decade?

The liver is a complex organ that performs vital functions of synthesis, heat production, detoxification and regulation; its failure carries a highly critical risk. At the end of the last century, some artific...

Authors: Juan José García Martínez and Karim Bendjelid

ICU physicians’ and internists’ survival predictions for patients evaluated for admission to the intensive care unit

A higher chance of survival is a key justification for admission to the intensive care unit (ICU). This implies that physicians should be able to accurately estimate a patient’s prognosis, whether cared for on...

Authors: Monica Escher, Bara Ricou, Mathieu Nendaz, Fabienne Scherer, Stéphane Cullati, Patricia Hudelson and Thomas Perneger