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  1. Animal experiments are widely used in preclinical medical research with the goal of disease modeling and exploration of novel therapeutic approaches. In the context of sepsis and septic shock, the translation ...

    Authors: Antoine Guillon, Sebastien Preau, Jérôme Aboab, Eric Azabou, Boris Jung, Stein Silva, Julien Textoris, Fabrice Uhel, Dominique Vodovar, Lara Zafrani, Nicolas de Prost and Peter Radermacher

    Citation: Annals of Intensive Care 2019 9:66

    Content type: Review

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  2. Although no specific treatment facilitates renal tubular regeneration in acute kidney injury (AKI), the rapid increase in aging populations with more comorbidities and advances in critical care management are ...

    Authors: Subin Hwang, Hyejeong Park, Youngha Kim, Danbee Kang, Ho Suk Ku, Juhee Cho, Jung Eun Lee, Wooseong Huh, Eliseo Guallar, Gee Young Suh and Hye Ryoun Jang

    Citation: Annals of Intensive Care 2019 9:65

    Content type: Research

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  3. The mechanisms of organ failure during sepsis are not fully understood. The hypothesis of circulating factors has been suggested to explain septic myocardial dysfunction. We explored the biological coherence o...

    Authors: Keyvan Razazi, Florence Boissier, Mathieu Surenaud, Alexandre Bedet, Aurélien Seemann, Guillaume Carteaux, Nicolas de Prost, Christian Brun-Buisson, Sophie Hue and Armand Mekontso Dessap

    Citation: Annals of Intensive Care 2019 9:64

    Content type: Research

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  4. Early clinical data showed that some patients with vasodilatory shock are responsive to low doses of angiotensin II. The objective of this analysis was to compare clinical outcomes in patients requiring ≤ 5 ng kg

    Authors: Kealy R. Ham, David W. Boldt, Michael T. McCurdy, Laurence W. Busse, Raphael Favory, Michelle N. Gong, Ashish K. Khanna, Stefan N. Chock, Feng Zeng, Lakhmir S. Chawla, George F. Tidmarsh and Marlies Ostermann

    Citation: Annals of Intensive Care 2019 9:63

    Content type: Research

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  5. Immunocompromised critically ill patients constitute a population with the high risk of candidemia. This retrospective study aimed to assess the outcome of immunocompromised critically ill patients with candid...

    Authors: Etienne Ghrenassia, Djamel Mokart, Julien Mayaux, Alexandre Demoule, Imène Rezine, Lionel Kerhuel, Laure Calvet, Audrey De Jong, Elie Azoulay and Michael Darmon

    Citation: Annals of Intensive Care 2019 9:62

    Content type: Research

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  6. Femoral dP/dtmax (maximum rate of the arterial pressure increase during systole) measured by pulse contour analysis has been proposed as a surrogate of left ventricular (LV) dP/dtmax and as an estimator of LV sys...

    Authors: Sergi Vaquer, Denis Chemla, Jean-Louis Teboul, Umar Ahmad, Flora Cipriani, Joan Carles Oliva, Ana Ochagavia, Antonio Artigas, Francisco Baigorri and Xavier Monnet

    Citation: Annals of Intensive Care 2019 9:61

    Content type: Research

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    The Letter to the Editor to this article has been published in Annals of Intensive Care 2019 9:111

  7. The actual effects of oxygen therapy on patients who have suffered a stroke are still unknown, and its recommendation as a routine measure in emergency services remains controversial. The aim of this study is ...

    Authors: Héctor Vargas López, Miguel Fernández Vivas, Rafael Núñez Ruiz, José Ros Martínez, Blanca García-Villalba Navaridas, Manuel García Villa, Cristina Llamas Lázaro, Rubén Jara Rubio, Ana Morales Ortiz, Laura Albert Lacal and Antonio Moreno Diéguez

    Citation: Annals of Intensive Care 2019 9:59

    Content type: Research

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  8. Muscular weakness developing from critical illness neuropathy, myopathy and muscle atrophy has been characterized as intensive care unit-acquired weakness (ICUAW). This entity occurs commonly during and after ...

    Authors: Paolo Formenti, Michele Umbrello, Silvia Coppola, Sara Froio and Davide Chiumello

    Citation: Annals of Intensive Care 2019 9:57

    Content type: Review

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  9. Although improving, the mortality from septic shock still remains high despite increased international awareness. As a consequence, much effort has focused on alternative treatment strategies in an effort to i...

    Authors: Patrick M. Honore, Eric Hoste, Zsolt Molnár, Rita Jacobs, Olivier Joannes-Boyau, Manu L. N. G. Malbrain and Lui G. Forni

    Citation: Annals of Intensive Care 2019 9:56

    Content type: Review

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  10. Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respir...

    Authors: Laura R. Schouten, Anton H. van Kaam, Franziska Kohse, Floor Veltkamp, Lieuwe D. Bos, Friso M. de Beer, Roosmarijn T. van Hooijdonk, Janneke Horn, Marleen Straat, Esther Witteveen, Gerie J. Glas, Luuk Wieske, Lonneke A. van Vught, Maryse A. Wiewel, Sarah A. Ingelse, Bart Cortjens…

    Citation: Annals of Intensive Care 2019 9:55

    Content type: Research

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  11. It is unknown whether the recommended mean arterial pressure (MAP) target of 65 mmHg during initial resuscitation of septic shock is sufficient to maintain cerebral perfusion. Thus, we tested the hypothesis th...

    Authors: Youenn Jouan, Valérie Seegers, Ferhat Meziani, Fabien Grelon, Bruno Megarbane, Nadia Anguel, Jean-Paul Mira, Pierre-François Dequin, Soizic Gergaud, Nicolas Weiss, François Legay, Yves Le Tulzo, Marie Conrad, René Robert, Frédéric Gonzalez, Christophe Guitton…

    Citation: Annals of Intensive Care 2019 9:54

    Content type: Research

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  12. Mortality of critically ill hematology (HM) patients has improved over time. Thus, those patients require an extensive diagnostic workup and the optimal use of available treatments. There are no data regarding...

    Authors: Florence Ettori, Aurélia Henin, Christophe Zemmour, Laurent Chow-Chine, Antoine Sannini, Magali Bisbal, Frédéric Gonzalez, Luca Servan, Jean Manuel de Guibert, Marion Faucher, Jean Marie Boher and Djamel Mokart

    Citation: Annals of Intensive Care 2019 9:53

    Content type: Research

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  13. The incidence of intra-abdominal hypertension (IAH) is high and still underappreciated by critical care physicians throughout the world. One in four to one in three patients will have IAH on admission, while o...

    Authors: Adrian Regli, Paolo Pelosi and Manu L. N. G. Malbrain

    Citation: Annals of Intensive Care 2019 9:52

    Content type: Review

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  14. Increased renal resistive index (RI) measured by Doppler ultrasonography has been shown to be associated with acute kidney injury (AKI) in septic patients. However, its clinical use is limited by poor sensitiv...

    Authors: François Beloncle, Natacha Rousseau, Jean-François Hamel, Alexis Donzeau, Anne-Lise Foucher, Marc-Antoine Custaud, Pierre Asfar, René Robert and Nicolas Lerolle

    Citation: Annals of Intensive Care 2019 9:51

    Content type: Research

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  15. Diaphragm paresis is common after cardiac surgery and may delay the weaning from the ventilator. Our objective was to evaluate diaphragm thickening during weaning and secondly the muscle thickness as a marker ...

    Authors: Pierre-Henri Moury, Adrien Cuisinier, Michel Durand, Jean-Luc Bosson, Olivier Chavanon, Jean-François Payen, Samir Jaber and Pierre Albaladejo

    Citation: Annals of Intensive Care 2019 9:50

    Content type: Research

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  16. Central venous catheters (CVCs) are commonly secured with sutures which are associated with microbial colonization and infection. We report a comparison of a suture-free system with standard sutures for securi...

    Authors: Tarja J. Karpanen, Anna L. Casey, Tony Whitehouse, Jean-Francois Timsit, Olivier Mimoz, Mercedes Palomar and Tom S. J. Elliott

    Citation: Annals of Intensive Care 2019 9:49

    Content type: Research

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  17. The aim of this study was to quantify the impact of different cardiovascular factors on left ventricular ejection fraction (LVEF) and test a novel LVEF calculation considering these factors.

    Authors: Manuel Ignacio Monge García, Zhongping Jian, Jos J. Settels, Charles Hunley, Maurizio Cecconi, Feras Hatib and Michael R. Pinsky

    Citation: Annals of Intensive Care 2019 9:48

    Content type: Research

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  18. The 2018 Paris Intensive Care symposium entitled “Update in Neurocritical Care” was organized in Paris, June 21–22, 2018, under the auspices of the French Intensive Care Society. This 2-day post-graduate educa...

    Authors: Mauro Oddo, Serge Bracard, Alain Cariou, Gérald Chanques, Giuseppe Citerio, Béatrix Clerckx, Bertrand Godeau, Anne Godier, Janneke Horn, Samir Jaber, Boris Jung, Khaldoun Kuteifan, Marc Leone, Alexandra Mailles, Mikael Mazighi, Bruno Mégarbane…

    Citation: Annals of Intensive Care 2019 9:47

    Content type: Review

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  19. Airway pressure release ventilation (APRV) has been considered a tempting mode of ventilation during acute respiratory failure within the concept of open lung ventilation. We performed a systematic review and ...

    Authors: Andrea Carsetti, Elisa Damiani, Roberta Domizi, Claudia Scorcella, Simona Pantanetti, Stefano Falcetta, Abele Donati and Erica Adrario

    Citation: Annals of Intensive Care 2019 9:44

    Content type: Research

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  20. Few studies analyzed gender-related outcome differences of critically ill patients and found inconsistent results. This study aimed to test the independent association of gender and long-term survival of ICU p...

    Authors: Alexa Hollinger, Etienne Gayat, Elodie Féliot, Catherine Paugam-Burtz, Marie-Céline Fournier, Jacques Duranteau, Jean-Yves Lefrant, Marc Leone, Samir Jaber, Alexandre Mebazaa and Mattia Arrigo

    Citation: Annals of Intensive Care 2019 9:43

    Content type: Research

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  21. Lung fibroproliferation in ARDS patients is associated with mortality. Alveolar procollagen III (NT-PCP-III) is a validated biomarker of lung fibroproliferation. A chest CT scan could be useful for the diagnos...

    Authors: Annabelle Hamon, Ugo Scemama, Jérémy Bourenne, Florence Daviet, Benjamin Coiffard, Nicolas Persico, Mélanie Adda, Christophe Guervilly, Sami Hraiech, Kathia Chaumoitre, Antoine Roch, Laurent Papazian and Jean-Marie Forel

    Citation: Annals of Intensive Care 2019 9:42

    Content type: Research

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  22. Lung-protective ventilation and prolonged prone positioning (PP) are presented as essential in treating acute respiratory distress syndrome (ARDS). The optimal respirator mode, however, remains controversial. ...

    Authors: Jascha Heider, Joachim Bansbach, Kai Kaufmann, Sebastian Heinrich, Torsten Loop and Johannes Kalbhenn

    Citation: Annals of Intensive Care 2019 9:41

    Content type: Research

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  23. To investigate the determinants and the prognosis of intensive care unit (ICU)-acquired pneumonia in patients with septic shock.

    Authors: Jean-François Llitjos, Aïcha Gassama, Julien Charpentier, Jérôme Lambert, Charles de Roquetaillade, Alain Cariou, Jean-Daniel Chiche, Jean-Paul Mira, Matthieu Jamme and Frédéric Pène

    Citation: Annals of Intensive Care 2019 9:39

    Content type: Research

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  24. Acute kidney injury (AKI) occurs in up to 50% of all critically ill patients and hemodynamic abnormalities are assumed to contribute, but their nature and share is still unclear. We explored the associations b...

    Authors: Renske Wiersema, Jacqueline Koeze, Bart Hiemstra, Ville Pettilä, Anders Perner, Frederik Keus and Iwan C. C. van der Horst

    Citation: Annals of Intensive Care 2019 9:38

    Content type: Research

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  25. Sepsis is one of the main reasons for intensive care unit admission and is responsible for high morbidity and mortality. The usual hemodynamic targets for resuscitation of patients with septic shock use macro-...

    Authors: Geoffroy Hariri, Jérémie Joffre, Guillaume Leblanc, Michael Bonsey, Jean-Remi Lavillegrand, Tomas Urbina, Bertrand Guidet, Eric Maury, Jan Bakker and Hafid Ait-Oufella

    Citation: Annals of Intensive Care 2019 9:37

    Content type: Review

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  26. Following the publication of the original article [1], the author reported a mistake in Fig. 1.

    Authors: Ignacio Martin-Loeches, Maria Consuelo Guia, Maria Sole Vallecoccia, David Suarez, Mercedes Ibarz, Marian Irazabal, Ricard Ferrer and Antonio Artigas

    Citation: Annals of Intensive Care 2019 9:36

    Content type: Correction

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    The original article was published in Annals of Intensive Care 2019 9:26

  27. Following publication of the original article [1], we have been notified that the tagging of the author name was done incorrectly in the XML version of the paper. The correct given name is Michele Claudio, and...

    Authors: Giorgio Berlot, Michele Claudio Vassallo, Nicola Busetto, Margarita Nieto Yabar, Tatiana Istrati, Silvia Baronio, Giada Quarantotto, Mattia Bixio, Giulia Barbati, Roberto Dattola, Irene Longo, Antonino Chillemi, Alice Scamperle, Fulvio Iscra and Ariella Tomasini

    Citation: Annals of Intensive Care 2019 9:33

    Content type: Correction

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    The original article was published in Annals of Intensive Care 2018 8:122

  28. To review the mechanisms of action, expected efficacy and side effects of strategies to control hyperkalemia in acutely ill patients.

    Authors: François Dépret, W. Frank Peacock, Kathleen D. Liu, Zubaid Rafique, Patrick Rossignol and Matthieu Legrand

    Citation: Annals of Intensive Care 2019 9:32

    Content type: Review

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  29. Cirrhosis is not recognised as one of the main risk factors of invasive pulmonary aspergillosis (IPA), although its prevalence is increasing. The aim of our study was to identify factors for IPA in such patien...

    Authors: Eric Levesque, Nawel Ait-Ammar, Daniela Dudau, Noémie Clavieras, Cyrille Feray, Françoise Foulet and Françoise Botterel

    Citation: Annals of Intensive Care 2019 9:31

    Content type: Research

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  30. Intravenous crystalloid solutions are administered commonly for critically ill patients. We performed this meta-analysis of randomized trials with trial sequential analysis (TSA) to evaluate effects of chlorid...

    Authors: Ming Xue, Xiwen Zhang, Feng Liu, Wei Chang, Jianfeng Xie, Jingyuan Xu, Yi Yang and Haibo Qiu

    Citation: Annals of Intensive Care 2019 9:30

    Content type: Research

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  31. Sepsis is characterized by a complex immune response. This meta-analysis evaluated the clinical effectiveness of intravenous IgM-enriched immunoglobulin (IVIgGM) in patients with sepsis and septic shock.

    Authors: Jie Cui, Xuxia Wei, Haijin Lv, Yuntao Li, Ping Li, Zhen Chen and Genglong Liu

    Citation: Annals of Intensive Care 2019 9:27

    Content type: Research

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  32. Age has been traditionally considered a risk factor for mortality in elderly patients admitted to intensive care units. The aim of this prospective, observational, multicenter cohort study is to determine the ...

    Authors: Ignacio Martin-Loeches, Maria Consuelo Guia, Maria Sole Vallecoccia, David Suarez, Mercedes Ibarz, Marian Irazabal, Ricard Ferrer and Antonio Artigas

    Citation: Annals of Intensive Care 2019 9:26

    Content type: Research

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    The Correction to this article has been published in Annals of Intensive Care 2019 9:36

  33. Checkpoint protein inhibitor antibodies (CPI), including cytotoxic T-lymphocyte-associated antigen 4 inhibitors (ipilimumab, tremelimumab) and the programmed cell death protein 1 pathway/programmed cell death ...

    Authors: Virginie Lemiale, Anne-Pascale Meert, François Vincent, Michael Darmon, Philippe R. Bauer, Andry Van de Louw and Elie Azoulay

    Citation: Annals of Intensive Care 2019 9:25

    Content type: Review

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  34. Few data are available on the impact of levosimendan in refractory cardiogenic shock patients undergoing peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO). The aim of this study was to eval...

    Authors: Shamir Vally, Cyril Ferdynus, Romain Persichini, Bruno Bouchet, Eric Braunberger, Hugo Lo Pinto, Olivier Martinet, David Vandroux, Thomas Aujoulat, Jérôme Allyn and Nicolas Allou

    Citation: Annals of Intensive Care 2019 9:24

    Content type: Research

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  35. The renal Doppler resistive index (renal RI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. However, many parameters have been described as influen...

    Authors: Raphael A. G. Oliveira, Pedro V. Mendes, Marcelo Park and Leandro U. Taniguchi

    Citation: Annals of Intensive Care 2019 9:23

    Content type: Research

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  36. Vasopressors are commonly applied to restore and maintain blood pressure in patients with sepsis. We aimed to evaluate the current practice and therapeutic goals regarding vasopressor use in septic shock as a ...

    Authors: Thomas W. L. Scheeren, Jan Bakker, Daniel De Backer, Djillali Annane, Pierre Asfar, E. Christiaan Boerma, Maurizio Cecconi, Arnaldo Dubin, Martin W. Dünser, Jacques Duranteau, Anthony C. Gordon, Olfa Hamzaoui, Glenn Hernández, Marc Leone, Bruno Levy, Claude Martin…

    Citation: Annals of Intensive Care 2019 9:20

    Content type: Research

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  37. Septic coagulopathy represents a very dynamic disease entity, tilting from initial hypercoagulability towards a subsequent hypocoagulable disease state, entitled overt disseminated intravascular coagulation. A...

    Authors: Felix Carl Fabian Schmitt, Vasil Manolov, Jakob Morgenstern, Thomas Fleming, Stefan Heitmeier, Florian Uhle, Mohammed Al-Saeedi, Thilo Hackert, Thomas Bruckner, Herbert Schöchl, Markus Alexander Weigand, Stefan Hofer and Thorsten Brenner

    Citation: Annals of Intensive Care 2019 9:19

    Content type: Research

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  38. The early postoperative period is critical for surgical patients. SOFA, SAPS 3 and APACHE II are prognostic scores widely used to predict mortality in ICU patients. This study aimed to evaluate these index tes...

    Authors: Antônio Luis Eiras Falcão, Alexandre Guimarães de Almeida Barros, Angela Alcântara Magnani Bezerra, Natália Lopes Ferreira, Claudinéia Muterle Logato, Filipa Pais Silva, Ana Beatriz Francioso Oliveira do Monte, Rodrigo Marques Tonella, Luciana Castilho de Figueiredo, Rui Moreno, Desanka Dragosavac and Nelson Adami Andreollo

    Citation: Annals of Intensive Care 2019 9:18

    Content type: Research

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  39. Infectious complications are a major cause of morbidity and mortality after heart transplantation (HT). However, the epidemiology and outcomes of these infections in the recent population of adult heart transp...

    Authors: Stéphanie Pons, Romain Sonneville, Lila Bouadma, Lenka Styfalova, Stéphane Ruckly, Mathilde Neuville, Aguila Radjou, Jordane Lebut, Marie-Pierre Dilly, Bruno Mourvillier, Richard Dorent, Patrick Nataf, Michel Wolff and Jean-François Timsit

    Citation: Annals of Intensive Care 2019 9:17

    Content type: Research

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