Articles

Patient–ventilator asynchrony during conventional mechanical ventilation in children

We aimed (1) to describe the characteristics of patient–ventilator asynchrony in a population of critically ill children, (2) to describe the risk factors associated with patient–ventilator asynchrony, and (3)...

Authors: Guillaume Mortamet, Alexandrine Larouche, Laurence Ducharme-Crevier, Olivier Fléchelles, Gabrielle Constantin, Sandrine Essouri, Amélie-Ann Pellerin-Leblanc, Jennifer Beck, Christer Sinderby, Philippe Jouvet and Guillaume Emeriaud

Application of updated guidelines on diastolic dysfunction in patients with severe sepsis and septic shock

Left ventricular diastolic dysfunction is suggested to be associated with higher mortality in severe sepsis and septic shock, yet the methods of diagnosis described in the literature are often inconsistent. Th...

Authors: David J. Clancy, Timothy Scully, Michel Slama, Stephen Huang, Anthony S. McLean and Sam R. Orde

Frequency and prognostic impact of basic critical care echocardiography abnormalities in patients with acute respiratory distress syndrome

Among intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS), apart from acute cor pulmonale (ACP), the frequency and prognostic impact of basic critical care echocardiography (BCCE...

Authors: Kay Choong See, Jeffrey Ng, Wen Ting Siow, Venetia Ong and Jason Phua

Risks of bleeding and thrombosis in intensive care unit patients with haematological malignancies

Patients with malignant haematological disease and especially those who require intensive care have an increased risk of bleeding and thrombosis, but none of these data were obtained in ICU patients only. We a...

Authors: Lene Russell, Lars Broksø Holst, Lars Kjeldsen, Jakob Stensballe and Anders Perner

Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats

Septic shock-induced disseminated intravascular coagulation is responsible for increased occurrence of multiple organ dysfunction and mortality. Immunothrombosis-induced coagulopathy may contribute to hypercoa...

Authors: Julie Helms, Raphaël Clere-Jehl, Elsa Bianchini, Pierrick Le Borgne, Mélanie Burban, Fatiha Zobairi, Jean-Luc Diehl, Lelia Grunebaum, Florence Toti, Ferhat Meziani and Delphine Borgel

Immunohaemostasis: a new view on haemostasis during sepsis

Host infection by a micro-organism triggers systemic inflammation, innate immunity and complement pathways, but also haemostasis activation. The role of thrombin and fibrin generation in host defence is now re...

Authors: Xavier Delabranche, Julie Helms and Ferhat Meziani

Does metformin exposure before ICU stay have any impact on patients’ outcome? A retrospective cohort study of diabetic patients

Impact of metformin exposure before ICU stay remains controversial. Metformin is thought to induce lactic acidosis and haemodynamic instability but may reduce ICU mortality. We evaluated its influence on outco...

Authors: Sebastien Jochmans, Jean-Emmanuel Alphonsine, Jonathan Chelly, Ly Van Phach Vong, Oumar Sy, Nathalie Rolin, Olivier Ellrodt, Mehran Monchi and Christophe Vinsonneau

Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?

Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened...

Authors: Antoine Dewitte, Sébastien Lepreux, Julien Villeneuve, Claire Rigothier, Christian Combe, Alexandre Ouattara and Jean Ripoche

Procalcitonin-guided antibiotic therapy in intensive care unit patients: a systematic review and meta-analysis

Serum procalcitonin (PCT) concentration is used to guide antibiotic decisions in choice, timing, and duration of anti-infection therapy to avoid antibiotic overuse. Thus, we performed a systematic review and m...

Authors: Hui-Bin Huang, Jin-Min Peng, Li Weng, Chun-Yao Wang, Wei Jiang and Bin Du

Piperacillin–tazobactam as alternative to carbapenems for ICU patients

Several studies suggest that alternatives to carbapenems, and particulary beta-lactam/beta-lactamase inhibitor combinations, can be used for therapy of extended-spectrum beta-lactamase-producing Enterobacteria...

Authors: Benoit Pilmis, Vincent Jullien, Alexis Tabah, Jean-Ralph Zahar and Christian Brun-Buisson

Admission of tetanus patients to the ICU: a retrospective multicentre study

An extended course of tetanus (up to 6 weeks) requiring ICU admission and protracted mechanical ventilation (MV) may have a significant impact on short- and long-term survival. The subject is noteworthy and d...

Authors: Rafael Mahieu, Thomas Reydel, Adel Maamar, Jean-Marc Tadié, Angeline Jamet, Arnaud W. Thille, Nicolas Chudeau, Julien Huntzinger, Steven Grangé, Gaetan Beduneau, Anne Courte, Stephane Ehrmann, Jérémie Lemarié, Sébastien Gibot, Michael Darmon, Christophe Guitton…

Venovenous extracorporeal membrane oxygenation devices-related colonisations and infections

Nosocomial infections occurring during extracorporeal membrane oxygenation (ECMO) support have already been reported, but few studied infections directly related to ECMO devices. This study aims to evaluate t...

Authors: Guillemette Thomas, Sami Hraiech, Nadim Cassir, Samuel Lehingue, Romain Rambaud, Sandrine Wiramus, Christophe Guervilly, Fanny Klasen, Mélanie Adda, Stéphanie Dizier, Antoine Roch, Laurent Papazian and Jean-Marie Forel

Effects of combination therapy using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation

No single anticoagulant has been proven effective for sepsis-associated disseminated intravascular coagulation (DIC). Thus, the concomitant use of antithrombin concentrate and recombinant thrombomodulin has be...

Authors: Toshiaki Iba, Akiyoshi Hagiwara, Daizoh Saitoh, Hideaki Anan, Yutaka Ueki, Koichi Sato and Satoshi Gando

Incidence of airway complications in patients using endotracheal tubes with continuous aspiration of subglottic secretions

Continuous aspiration of subglottic secretions is effective in preventing ventilator-associated pneumonia, but it involves a risk of mucosal damage. The main objective of our study was to determine the inciden...

Authors: Jordi Vallés, Susana Millán, Emili Díaz, Eva Castanyer, Xavier Gallardo, Ignacio Martín-Loeches, Marta Andreu, Mario Prenafeta, Paula Saludes, Jorge Lema, Montse Batlle, Néstor Bacelar and Antoni Artigas

Risk stratification using SpO₂/FiO₂ and PEEP at initial ARDS diagnosis and after 24 h in patients with moderate or severe ARDS

We assessed the potential of risk stratification of ARDS patients using SpO₂/FiO₂ and positive end-expiratory pressure (PEEP) at ARDS onset and after 24 h.

Authors: Luigi Pisani, Jan-Paul Roozeman, Fabienne D. Simonis, Antonio Giangregorio, Sophia M. van der Hoeven, Laura R. Schouten, Janneke Horn, Ary Serpa Neto, Emir Festic, Arjen M. Dondorp, Salvatore Grasso, Lieuwe D. Bos and Marcus J. Schultz

Anemia at pediatric intensive care unit discharge: prevalence and risk markers

Anemia is prevalent at pediatric intensive care unit (PICU) admission and incident during PICU stay, but little is known about anemia at PICU discharge . Anemia after critical illness is an important issue bec...

Authors: Pierre Demaret, Oliver Karam, Marisa Tucci, Jacques Lacroix, Hélène Behal, Alain Duhamel, Frédéric Lebrun, André Mulder and Stéphane Leteurtre

Protective effect of early low-dose hydrocortisone on ventilator-associated pneumonia in the cancer patients: a propensity score analysis

Ventilator-associated pneumonia (VAP) is a care-related event that could be promoted by immune suppression caused by critical diseases, malignancies and cancer treatments. Low dose of hydrocortisone was propos...

Authors: David Lagier, Laura Platon, Jérome Lambert, Laurent Chow-Chine, Antoine Sannini, Magali Bisbal, Jean-Paul Brun, Karim Asehnoune, Marc Leone, Marion Faucher and Djamel Mokart

Heparin-binding protein (HBP) improves prediction of sepsis-related acute kidney injury

Sepsis-related acute kidney injury (AKI) accounts for major morbidity and mortality among the critically ill. Heparin-binding protein (HBP) is a promising biomarker in predicting development and prognosis of s...

Authors: Jonas Tverring, Suvi T. Vaara, Jane Fisher, Meri Poukkanen, Ville Pettilä and Adam Linder

Ultrasound assessment of rectus femoris and anterior tibialis muscles in young trauma patients

Quantitative and qualitative changes of skeletal muscle are typical and early findings in trauma patients, being possibly associated with functional impairment. Early assessment of muscle changes—as evaluated ...

Authors: Maria Giuseppina Annetta, Mauro Pittiruti, Davide Silvestri, Domenico Luca Grieco, Alessio Maccaglia, Michele Fabio La Torre, Nicola Magarelli, Giovanna Mercurio, Anselmo Caricato and Massimo Antonelli

Outcome of in- and out-of-hospital cardiac arrest survivors with liver cirrhosis

Organ failure increases mortality in patients with liver cirrhosis. Data about resuscitated cardiac arrest patients with liver cirrhosis are missing. This study aims to assess aetiology, survival and functiona...

Authors: Kevin Roedl, Christian Wallmüller, Andreas Drolz, Thomas Horvatits, Karoline Rutter, Alexander Spiel, Julia Ortbauer, Peter Stratil, Pia Hubner, Christoph Weiser, Jasmin Katrin Motaabbed, Dominik Jarczak, Harald Herkner, Fritz Sterz and Valentin Fuhrmann

Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction

Disruption of the endothelial glycocalyx contributes to acute lung injury in experimental sepsis but has not been well studied in humans. To study glycocalyx degradation in sepsis-induced ARDS, we measured pla...

Authors: Laura S. Murphy, Nancy Wickersham, J. Brennan McNeil, Ciara M. Shaver, Addison K. May, Julie A. Bastarache and Lorraine B. Ware

Prognostic implications of blood lactate concentrations after cardiac arrest: a retrospective study

Elevated lactate concentration has been associated with increased mortality after out-of-hospital cardiac arrest (CA). We investigated the variables associated with high blood lactate concentrations and explor...

Authors: Antonio Maria Dell’Anna, Claudio Sandroni, Irene Lamanna, Ilaria Belloni, Katia Donadello, Jacques Creteur, Jean-Louis Vincent and Fabio Silvio Taccone

Effect of inspiratory synchronization during pressure-controlled ventilation on lung distension and inspiratory effort

In pressure-controlled (PC) ventilation, tidal volume (V _T) and transpulmonary pressure (P _L ) result from the addition...

Authors: Nuttapol Rittayamai, François Beloncle, Ewan C. Goligher, Lu Chen, Jordi Mancebo, Jean-Christophe M. Richard and Laurent Brochard

The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case–control study

Acetaminophen (APAP)-induced acute liver failure (ALF) is associated with significant mortality due to intracranial hypertension (ICH), a result of cerebral edema (CE) and astrocyte swelling. Brain-type fatty ...

Authors: Constantine J. Karvellas, Jaime L. Speiser, Mélanie Tremblay, William M. Lee and Christopher F. Rose

Interstitial pneumonia with autoimmune features: an additional risk factor for ARDS?

Interstitial pneumonia with autoimmune features (IPAF) identifies a recently recognized autoimmune syndrome characterized by interstitial lung disease and autoantibodies positivity, but absence of a specific c...

Authors: Giacomo Grasselli, Beatrice Vergnano, Maria Rosa Pozzi, Vittoria Sala, Gabriele D’Andrea, Vittorio Scaravilli, Marco Mantero, Alberto Pesci and Antonio Pesenti

High level of venous thromboembolism in critically ill trauma patients despite early and well-driven thromboprophylaxis protocol

Venous thromboembolism (VTE) is one of the most common preventable causes of in-hospital death in trauma patients surviving their injuries. We assessed the prevalence, incidence and risk factors for deep venou...

Authors: S. R. Hamada, C. Espina, T. Guedj, R. Buaron, A. Harrois, S. Figueiredo and J. Duranteau

Derivation and validation of a prognostic model for postoperative risk stratification of critically ill patients with faecal peritonitis

Prognostic scores and models of illness severity are useful both clinically and for research. The aim of this study was to develop two prognostic models for the prediction of long-term (6 months) and 28-day m...

Authors: Ascanio Tridente, Julian Bion, Gary H. Mills, Anthony C. Gordon, Geraldine. M. Clarke, Andrew Walden, Paula Hutton, Paul A. H. Holloway, Jean-Daniel Chiche, Frank Stuber, Christopher Garrard and Charles Hinds

Short-term effects of passive mobilization on the sublingual microcirculation and on the systemic circulation in patients with septic shock

Active mobilization is not possible in patients under deep sedation and unable to follow commands. In this scenario, passive therapy is an interesting alternative. However, in patients with septic shock, passi...

Authors: Tuanny Teixeira Pinheiro, Flávio Geraldo Rezende de Freitas, Karla Tuanny Fiorese Coimbra, Vanessa Marques Ferreira Mendez, Heloísa Baccaro Rossetti, Paulo Vinicius Talma, Antônio Tonete Bafi and Flávia Ribeiro Machado

Prognostic impact of isolated right ventricular dysfunction in sepsis and septic shock: an 8-year historical cohort study

Echocardiographic myocardial dysfunction is reported commonly in sepsis and septic shock, but there are limited data on sepsis-related right ventricular dysfunction. This study sought to evaluate the associati...

Authors: Saraschandra Vallabhajosyula, Mukesh Kumar, Govind Pandompatam, Ankit Sakhuja, Rahul Kashyap, Kianoush Kashani, Ognjen Gajic, Jeffrey B. Geske and Jacob C. Jentzer

Endocan as an early biomarker of severity in patients with acute respiratory distress syndrome

Plasma concentrations of endocan, a proteoglycan preferentially expressed in the pulmonary vasculature, may represent a biomarker of lung (dys)function. We sought to determine whether the measurement of plasma...

Authors: Diego Orbegozo, Lokmane Rahmania, Marian Irazabal, Manuel Mendoza, Filippo Annoni, Daniel De Backer, Jacques Creteur and Jean-Louis Vincent

Cell-cycle arrest biomarkers in urine to predict acute kidney injury in septic and non-septic critically ill patients

To analyse the usefulness of the composite index of the tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) as urinary biomarkers for the early predictio...

Authors: M. Cuartero, J. Ballús, J. Sabater, X. Pérez, N. Nin, J. Ordonez-Llanos and A. J. Betbesé

Comparison of diagnostic accuracy in sepsis between presepsin, procalcitonin, and C-reactive protein: a systematic review and meta-analysis

The soluble cluster of differentiation 14 (or presepsin) is a free fragment of glycoprotein expressed on monocytes and macrophages. Although many studies have been conducted recently, the diagnostic performan...

Authors: Chin-Chieh Wu, Hao-Min Lan, Shih-Tsung Han, Chung-Hsien Chaou, Chun-Fu Yeh, Su-Hsun Liu, Chih-Huang Li, Gerald N. Blaney III, Zhen-Ying Liu and Kuan-Fu Chen

Astragaloside-IV prevents acute kidney injury and inflammation by normalizing muscular mitochondrial function associated with a nitric oxide protective mechanism in crush syndrome rats

Crush syndrome (CS) is a serious medical condition characterized by muscle cell damage resulting from decompression after compression (i.e., ischemia/reperfusion injury). A large number of CS patients develop ...

Authors: Isamu Murata, Yuji Abe, Yuka Yaginuma, Kayako Yodo, Yuka Kamakari, Yurika Miyazaki, Daichi Baba, Yuko Shinoda, Toru Iwasaki, Kunihiko Takahashi, Jun Kobayashi, Yutaka Inoue and Ikuo Kanamoto

Hemofiltration induces generation of leukocyte-derived CD31+/CD41− microvesicles in sepsis

Microvesicles (MV) are extracellular vesicles known to be associated with cellular activation and inflammation. Hemofiltration is an effective blood purification technique for patients with renal failure and p...

Authors: Georg Franz Lehner, Ulrich Harler, Clemens Feistritzer, Viktoria Maria Haller, Julia Hasslacher, Romuald Bellmann and Michael Joannidis

Opioid-associated iatrogenic withdrawal in critically ill adult patients: a multicenter prospective observational study

Opioids and benzodiazepines are frequently used in the intensive care unit (ICU). Regular use and prolonged exposure to opioids in ICU patients followed by abrupt tapering or cessation may lead to iatrogenic w...

Authors: Pan Pan Wang, Elaine Huang, Xue Feng, Charles-André Bray, Marc M. Perreault, Philippe Rico, Patrick Bellemare, Paul Murgoi, Céline Gélinas, Annie Lecavalier, Dev Jayaraman, Anne Julie Frenette and David Williamson

Prognostic indicators of survival and survival prediction model following extracorporeal cardiopulmonary resuscitation in patients with sudden refractory cardiac arrest

Extracorporeal cardiopulmonary resuscitation (ECPR) has been considered in selected candidates with potentially reversible causes during a limited period. Candidate selection and the identification of predicta...

Authors: Sung Woo Lee, Kap Su Han, Jong Su Park, Ji Sung Lee and Su Jin Kim

Validation of transpulmonary thermodilution variables in hemodynamically stable patients with heart diseases

Transpulmonary thermodilution is recommended in the treatment of critically ill patients presenting with complex shock. However, so far it has not been validated in hemodynamically stable patients with heart d...

Authors: Matthias Peter Hilty, Daniel Peter Franzen, Christophe Wyss, Patric Biaggi and Marco Maggiorini

Lymphopaenia in cardiac arrest patients

A decrease in circulating lymphocytes has been described as a marker of poor prognosis after septic shock; however, scarce data are available after cardiac arrest (CA). The aim of this study was to evaluate th...

Authors: Paola Villois, David Grimaldi, Savino Spadaro, Claudia Righy Shinotsuka, Vito Fontana, Sabino Scolletta, Federico Franchi, Jean-Louis Vincent, Jacques Creteur and Fabio Silvio Taccone

Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model

Blood purification is an emerging approach to dampening the cytokine storm. This study aims to assess the efficacy of HA330 resin-directed hemoadsorption (HA) on endotoxin-induced porcine acute respiratory dis...

Authors: Xuefeng Xu, Chune Jia, Sa Luo, Yanming Li, Fei Xiao, Huaping Dai and Chen Wang

Association between elevated central venous pressure and outcomes in critically ill patients

Some prior studies have shown that elevated mean central venous pressure in certain patient populations and disease processes may lead to poor prognosis. However, these studies failed to generalize the concept...

Authors: Dong-kai Li, Xiao-ting Wang and Da-wei Liu

Efficacy and safety of argatroban in patients with acute respiratory distress syndrome and extracorporeal lung support

Extracorporeal membrane oxygenation (ECMO) or pumpless extracorporeal lung assist (pECLA) requires effective anticoagulation. Knowledge on the use of argatroban in patients with acute respiratory distress synd...

Authors: Mario Menk, Philipp Briem, Björn Weiss, Martina Gassner, David Schwaiberger, Anton Goldmann, Christian Pille and Steffen Weber-Carstens

Feasibility and safety of virtual-reality-based early neurocognitive stimulation in critically ill patients

Growing evidence suggests that critical illness often results in significant long-term neurocognitive impairments in one-third of survivors. Although these neurocognitive impairments are long-lasting and devas...

Authors: Marc Turon, Sol Fernandez-Gonzalo, Mercè Jodar, Gemma Gomà, Jaume Montanya, David Hernando, Raquel Bailón, Candelaria de Haro, Victor Gomez-Simon, Josefina Lopez-Aguilar, Rudys Magrans, Melcior Martinez-Perez, Joan Carles Oliva and Lluís Blanch

Assessment of sepsis-induced immunosuppression at ICU discharge and 6 months after ICU discharge

Increase in mortality and in recurrent infections in the year following ICU discharge continues in survivors of septic shock, even after total clinical recovery from the initial septic event and its complicati...

Authors: Violette Zorio, Fabienne Venet, Benjamin Delwarde, Bernard Floccard, Guillaume Marcotte, Julien Textoris, Guillaume Monneret and Thomas Rimmelé

How to reduce cisatracurium consumption in ARDS patients: the TOF-ARDS study

Neuromuscular blocking agents (NMBAs) have been shown to improve the outcome of the most severely hypoxemic, acute respiratory distress syndrome (ARDS) patients. However, the recommended dosage as well as the ...

Authors: Sami Hraiech, Jean-Marie Forel, Christophe Guervilly, Romain Rambaud, Samuel Lehingue, Mélanie Adda, Pierre Sylla, Sabine Valera, Julien Carvelli, Marc Gainnier, Laurent Papazian and Jérémy Bourenne

Nebulized antibiotics in mechanically ventilated patients: a challenge for translational research from technology to clinical care

Nebulized antibiotic therapy directly targets airways and lung parenchyma resulting in high local concentrations and potentially lower systemic toxicities. Experimental and clinical studies have provided evide...

Authors: Stephan Ehrmann, Jean Chastre, Patrice Diot and Qin Lu

Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks

Intermittent hemodialysis (IHD) is the modality of choice in the extracorporeal treatment (ECTR) of acute methanol poisoning. However, the comparative clinical effectiveness of intermittent versus continuous m...

Authors: Sergey Zakharov, Jan Rulisek, Olga Nurieva, Katerina Kotikova, Tomas Navratil, Martin Komarc, Daniela Pelclova and Knut Erik Hovda

Bedside selection of positive end-expiratory pressure by electrical impedance tomography in hypoxemic patients: a feasibility study

Positive end-expiratory pressure (PEEP) is a key element of mechanical ventilation. It should optimize recruitment, without causing excessive overdistension, but controversy exists on the best method to set it...

Authors: Nilde Eronia, Tommaso Mauri, Elisabetta Maffezzini, Stefano Gatti, Alfio Bronco, Laura Alban, Filippo Binda, Tommaso Sasso, Cristina Marenghi, Giacomo Grasselli, Giuseppe Foti, Antonio Pesenti and Giacomo Bellani

Erratum to: Practice of hemodynamic monitoring and management in German, Austrian, and Swiss intensive care units: the multicenter cross-sectional ICU-CardioMan Study

Authors: Sandra Funcke, Michael Sander, Matthias S. Goepfert, Heinrich Groesdonk, Matthias Heringlake, Jan Hirsch, Stefan Kluge, Claus Krenn, Marco Maggiorini, Patrick Meybohm, Cornelie Salzwedel, Bernd Saugel, Gudrun Wagenpfeil, Stefan Wagenpfeil and Daniel A. Reuter

Effect of insulin infusion line on glycaemic variability in a perioperative high dependency unit (HDU): a prospective randomised controlled trial

Glucose control is an important issue in post-operative patients. The objective here was to compare two insulin infusion lines by syringe pumps to assess the impact of medical devices on glycaemic variability ...

Authors: Stéphanie Genay, Bertrand Décaudin, Sabine Ethgen, Arnaud Alluin, Elodie Babol, Julien Labreuche, Hélène Behal, Marie-Christine Vantyghem, Pascal Odou and Gilles Lebuffe

Epidemiology of extended-spectrum beta-lactamase-producing Enterobacteriaceae in an intensive care unit with no single rooms

The transmission of extended-spectrum beta-lactamase-producing enterobacteriaceae (ESBL) is prevented by additional contact precautions, mainly relying on isolation in a single room and hand hygiene. Contact isol...

Authors: Xavier Repessé, Margaux Artiguenave, Sophie Paktoris-Papine, Florence Espinasse, Aurélien Dinh, Cyril Charron, Faten El Sayed, Guillaume Geri and Antoine Vieillard-Baron