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  1. Content type: Research

    Crush syndrome (CS) is a serious medical condition characterized by muscle cell damage resulting from decompression after compression (i.e., ischemia/reperfusion injury). A large number of CS patients develop ...

    Authors: Isamu Murata, Yuji Abe, Yuka Yaginuma, Kayako Yodo, Yuka Kamakari, Yurika Miyazaki, Daichi Baba, Yuko Shinoda, Toru Iwasaki, Kunihiko Takahashi, Jun Kobayashi, Yutaka Inoue and Ikuo Kanamoto

    Citation: Annals of Intensive Care 2017 7:90

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  2. Content type: Research

    Microvesicles (MV) are extracellular vesicles known to be associated with cellular activation and inflammation. Hemofiltration is an effective blood purification technique for patients with renal failure and p...

    Authors: Georg Franz Lehner, Ulrich Harler, Clemens Feistritzer, Viktoria Maria Haller, Julia Hasslacher, Romuald Bellmann and Michael Joannidis

    Citation: Annals of Intensive Care 2017 7:89

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  3. Content type: Research

    Opioids and benzodiazepines are frequently used in the intensive care unit (ICU). Regular use and prolonged exposure to opioids in ICU patients followed by abrupt tapering or cessation may lead to iatrogenic w...

    Authors: Pan Pan Wang, Elaine Huang, Xue Feng, Charles-André Bray, Marc M. Perreault, Philippe Rico, Patrick Bellemare, Paul Murgoi, Céline Gélinas, Annie Lecavalier, Dev Jayaraman, Anne Julie Frenette and David Williamson

    Citation: Annals of Intensive Care 2017 7:88

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  4. Content type: Research

    Extracorporeal cardiopulmonary resuscitation (ECPR) has been considered in selected candidates with potentially reversible causes during a limited period. Candidate selection and the identification of predicta...

    Authors: Sung Woo Lee, Kap Su Han, Jong Su Park, Ji Sung Lee and Su Jin Kim

    Citation: Annals of Intensive Care 2017 7:87

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  5. Content type: Research

    Transpulmonary thermodilution is recommended in the treatment of critically ill patients presenting with complex shock. However, so far it has not been validated in hemodynamically stable patients with heart d...

    Authors: Matthias Peter Hilty, Daniel Peter Franzen, Christophe Wyss, Patric Biaggi and Marco Maggiorini

    Citation: Annals of Intensive Care 2017 7:86

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  6. Content type: Research

    A decrease in circulating lymphocytes has been described as a marker of poor prognosis after septic shock; however, scarce data are available after cardiac arrest (CA). The aim of this study was to evaluate th...

    Authors: Paola Villois, David Grimaldi, Savino Spadaro, Claudia Righy Shinotsuka, Vito Fontana, Sabino Scolletta, Federico Franchi, Jean-Louis Vincent, Jacques Creteur and Fabio Silvio Taccone

    Citation: Annals of Intensive Care 2017 7:85

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  7. Content type: Research

    Blood purification is an emerging approach to dampening the cytokine storm. This study aims to assess the efficacy of HA330 resin-directed hemoadsorption (HA) on endotoxin-induced porcine acute respiratory dis...

    Authors: Xuefeng Xu, Chune Jia, Sa Luo, Yanming Li, Fei Xiao, Huaping Dai and Chen Wang

    Citation: Annals of Intensive Care 2017 7:84

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  8. Content type: Research

    Extracorporeal membrane oxygenation (ECMO) or pumpless extracorporeal lung assist (pECLA) requires effective anticoagulation. Knowledge on the use of argatroban in patients with acute respiratory distress synd...

    Authors: Mario Menk, Philipp Briem, Björn Weiss, Martina Gassner, David Schwaiberger, Anton Goldmann, Christian Pille and Steffen Weber-Carstens

    Citation: Annals of Intensive Care 2017 7:82

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  9. Content type: Research

    Growing evidence suggests that critical illness often results in significant long-term neurocognitive impairments in one-third of survivors. Although these neurocognitive impairments are long-lasting and devas...

    Authors: Marc Turon, Sol Fernandez-Gonzalo, Mercè Jodar, Gemma Gomà, Jaume Montanya, David Hernando, Raquel Bailón, Candelaria de Haro, Victor Gomez-Simon, Josefina Lopez-Aguilar, Rudys Magrans, Melcior Martinez-Perez, Joan Carles Oliva and Lluís Blanch

    Citation: Annals of Intensive Care 2017 7:81

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  10. Content type: Research

    Increase in mortality and in recurrent infections in the year following ICU discharge continues in survivors of septic shock, even after total clinical recovery from the initial septic event and its complicati...

    Authors: Violette Zorio, Fabienne Venet, Benjamin Delwarde, Bernard Floccard, Guillaume Marcotte, Julien Textoris, Guillaume Monneret and Thomas Rimmelé

    Citation: Annals of Intensive Care 2017 7:80

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  11. Content type: Research

    Neuromuscular blocking agents (NMBAs) have been shown to improve the outcome of the most severely hypoxemic, acute respiratory distress syndrome (ARDS) patients. However, the recommended dosage as well as the ...

    Authors: Sami Hraiech, Jean-Marie Forel, Christophe Guervilly, Romain Rambaud, Samuel Lehingue, Mélanie Adda, Pierre Sylla, Sabine Valera, Julien Carvelli, Marc Gainnier, Laurent Papazian and Jérémy Bourenne

    Citation: Annals of Intensive Care 2017 7:79

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  12. Content type: Review

    Nebulized antibiotic therapy directly targets airways and lung parenchyma resulting in high local concentrations and potentially lower systemic toxicities. Experimental and clinical studies have provided evide...

    Authors: Stephan Ehrmann, Jean Chastre, Patrice Diot and Qin Lu

    Citation: Annals of Intensive Care 2017 7:78

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  13. Content type: Research

    Intermittent hemodialysis (IHD) is the modality of choice in the extracorporeal treatment (ECTR) of acute methanol poisoning. However, the comparative clinical effectiveness of intermittent versus continuous m...

    Authors: Sergey Zakharov, Jan Rulisek, Olga Nurieva, Katerina Kotikova, Tomas Navratil, Martin Komarc, Daniela Pelclova and Knut Erik Hovda

    Citation: Annals of Intensive Care 2017 7:77

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  14. Content type: Research

    Positive end-expiratory pressure (PEEP) is a key element of mechanical ventilation. It should optimize recruitment, without causing excessive overdistension, but controversy exists on the best method to set it...

    Authors: Nilde Eronia, Tommaso Mauri, Elisabetta Maffezzini, Stefano Gatti, Alfio Bronco, Laura Alban, Filippo Binda, Tommaso Sasso, Cristina Marenghi, Giacomo Grasselli, Giuseppe Foti, Antonio Pesenti and Giacomo Bellani

    Citation: Annals of Intensive Care 2017 7:76

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  15. Content type: Erratum

    Authors: Sandra Funcke, Michael Sander, Matthias S. Goepfert, Heinrich Groesdonk, Matthias Heringlake, Jan Hirsch, Stefan Kluge, Claus Krenn, Marco Maggiorini, Patrick Meybohm, Cornelie Salzwedel, Bernd Saugel, Gudrun Wagenpfeil, Stefan Wagenpfeil and Daniel A. Reuter

    Citation: Annals of Intensive Care 2017 7:75

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    The original article was published in Annals of Intensive Care 2016 6:49

  16. Content type: Research

    Glucose control is an important issue in post-operative patients. The objective here was to compare two insulin infusion lines by syringe pumps to assess the impact of medical devices on glycaemic variability ...

    Authors: Stéphanie Genay, Bertrand Décaudin, Sabine Ethgen, Arnaud Alluin, Elodie Babol, Julien Labreuche, Hélène Behal, Marie-Christine Vantyghem, Pascal Odou and Gilles Lebuffe

    Citation: Annals of Intensive Care 2017 7:74

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  17. Content type: Research

    The transmission of extended-spectrum beta-lactamase-producing enterobacteriaceae (ESBL) is prevented by additional contact precautions, mainly relying on isolation in a single room and hand hygiene. Contact isol...

    Authors: Xavier Repessé, Margaux Artiguenave, Sophie Paktoris-Papine, Florence Espinasse, Aurélien Dinh, Cyril Charron, Faten El Sayed, Guillaume Geri and Antoine Vieillard-Baron

    Citation: Annals of Intensive Care 2017 7:73

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  18. Content type: Research

    Antibiotics are frequently used in intensive care units (ICUs), and their use is associated with the emergence of bacterial resistance to antibiotics. The aim of this study was to investigate the association b...

    Authors: Erlangga Yusuf, Bruno Van Herendael, Walter Verbrugghe, Margareta Ieven, Emiel Goovaerts, Kristof Bergs, Kristien Wouters, Philippe G. Jorens and Herman Goossens

    Citation: Annals of Intensive Care 2017 7:72

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  19. Content type: Research

    Burnout appears to be common among critical care providers. It is characterized by three components: emotional exhaustion, depersonalization and personal accomplishment. Moral distress is the inability of a mo...

    Authors: Renata Rego Lins Fumis, Gustavo Adolpho Junqueira Amarante, Andréia de Fátima Nascimento and José Mauro Vieira Junior

    Citation: Annals of Intensive Care 2017 7:71

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  20. Content type: Review

    Over the recent period, the use of induced hypothermia has gained an increasing interest for critically ill patients, in particular in brain-injured patients. The term “targeted temperature management” (TTM) h...

    Authors: Alain Cariou, Jean-François Payen, Karim Asehnoune, Gerard Audibert, Astrid Botte, Olivier Brissaud, Guillaume Debaty, Sandrine Deltour, Nicolas Deye, Nicolas Engrand, Gilles Francony, Stéphane Legriel, Bruno Levy, Philippe Meyer, Jean-Christophe Orban, Sylvain Renolleau…

    Citation: Annals of Intensive Care 2017 7:70

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  21. Content type: Research

    Patients meeting the Berlin definition for the acute respiratory distress syndrome (ARDS) might lack exposure to one or more “common” risk factors and exhibit different clinical phenotype and outcomes. We aime...

    Authors: Nicolas de Prost, Tài Pham, Guillaume Carteaux, Armand Mekontso Dessap, Christian Brun-Buisson, Eddy Fan, Giacomo Bellani, John Laffey, Alain Mercat, Laurent Brochard and Bernard Maître

    Citation: Annals of Intensive Care 2017 7:69

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  22. Content type: Research

    Early-onset ventilator-associated pneumonia (EO-VAP) is the leading cause of morbidity and mortality in comatose patients. However, VAP prevention bundles focus mainly on late-onset VAP and may be less effecti...

    Authors: Cássia Righy, Pedro Emmanuel Americano do Brasil, Jordi Vallés, Fernando A. Bozza and Ignacio Martin-Loeches

    Citation: Annals of Intensive Care 2017 7:67

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  23. Content type: Research

    According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloid...

    Authors: Pierre-Yves Olivier, François Beloncle, Valérie Seegers, Maher Tabka, Mathilde Renou de La Bourdonnaye, Alain Mercat, Paul Cales, Daniel Henrion, Peter Radermacher, Lise Piquilloud, Nicolas Lerolle and Pierre Asfar

    Citation: Annals of Intensive Care 2017 7:66

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  24. Content type: Research

    The identification of anaerobic metabolism in critically ill patients is a challenging task. Observational studies have suggested that the ratio of venoarterial PCO2 (Pv–aCO2) to arteriovenous oxygen content diff...

    Authors: Arnaldo Dubin, Gonzalo Ferrara, Vanina Siham Kanoore Edul, Enrique Martins, Héctor Saúl Canales, Carlos Canullán, Gastón Murias, Mario Omar Pozo and Elisa Estenssoro

    Citation: Annals of Intensive Care 2017 7:65

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  25. Content type: Research

    Early exercise of critically ill patients may have beneficial effects on muscle strength, mass and systemic inflammation. During pressure support ventilation (PSV), a mismatch between demand and assist could i...

    Authors: Evangelia Akoumianaki, Nicolas Dousse, Aissam Lyazidi, Jean-Claude Lefebvre, Severine Graf, Ricardo Luiz Cordioli, Nathalie Rey, Jean-Christophe Marie Richard and Laurent Brochard

    Citation: Annals of Intensive Care 2017 7:64

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  26. Content type: Research

    Somatosensory (SSEP) and brainstem auditory (BAEP) evoked potentials are neurophysiological tools which, respectively, explore the intracranial conduction time (ICCT) and the intrapontine conduction time (IPCT...

    Authors: Eric Azabou, Benjamin Rohaut, Nicholas Heming, Eric Magalhaes, Régine Morizot-Koutlidis, Stanislas Kandelman, Jeremy Allary, Guy Moneger, Andrea Polito, Virginie Maxime, Djillali Annane, Frederic Lofaso, Fabrice Chrétien, Jean Mantz, Raphael Porcher and Tarek Sharshar

    Citation: Annals of Intensive Care 2017 7:63

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  27. Content type: Research

    Indications for red blood cell (RBC) transfusion in septic acute circulatory failure remain unclear. We addressed the practices and the prognostic impact of RBC transfusion in the early resuscitation of severe...

    Authors: Adrien Mirouse, Matthieu Resche-Rigon, Virginie Lemiale, Djamel Mokart, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne Renault, Anne-Pascale Meert, Dominique Benoit, Rebecca Hamidfar…

    Citation: Annals of Intensive Care 2017 7:62

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  28. Content type: Research

    We assessed prevalence, associated factors and prognosis of extended-spectrum beta-lactamase-producing Enterobacteriaceae pneumonia acquired in intensive care unit (ESBL-PE pneumonia) among carriers. Variable...

    Authors: Keyvan Razazi, Armand Mekontso Dessap, Guillaume Carteaux, Chloé Jansen, Jean-Winoc Decousser, Nicolas de Prost and Christian Brun-Buisson

    Citation: Annals of Intensive Care 2017 7:61

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  29. Content type: Research

    The protective cardiovascular effect of high-density lipoproteins (HDLs) is considered to chiefly rely on reverse cholesterol transport from peripheral tissues back to the liver. However, HDL particles display...

    Authors: Sébastien Tanaka, Julien Labreuche, Elodie Drumez, Anatole Harrois, Sophie Hamada, Bernard Vigué, David Couret, Jacques Duranteau and Olivier Meilhac

    Citation: Annals of Intensive Care 2017 7:60

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  30. Content type: Review

    When used as a driving gas during NIV in hypercapnic COPD exacerbation, a helium–oxygen (He/O2) mixture reduces the work of breathing and gas trapping. The potential for He/O2 to reduce the rate of NIV failure le...

    Authors: Fekri Abroug, Lamia Ouanes-Besbes, Zeineb Hammouda, Saoussen Benabidallah, Fahmi Dachraoui, Islem Ouanes and Philippe Jolliet

    Citation: Annals of Intensive Care 2017 7:59

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  31. Content type: Research

    Nutritional supplementation of omega-3 fatty acids has been proposed to modulate the balance of pro- and anti-inflammatory mediators in sepsis. If proved to improve clinical outcomes in critically ill patients...

    Authors: Clara Lu, Sunjay Sharma, Lauralyn McIntyre, Andrew Rhodes, Laura Evans, Saleh Almenawer, Lori Leduc, Derek C. Angus and Waleed Alhazzani

    Citation: Annals of Intensive Care 2017 7:58

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  32. Content type: Research

    Compliance with the clinical practice guidelines of sepsis management has been low. The objective of our study was to describe the results of implementing a multifaceted intervention including an electronic al...

    Authors: Yaseen M. Arabi, Hasan M. Al-Dorzi, Ahmed Alamry, Ra’ed Hijazi, Sami Alsolamy, Majid Al Salamah, Hani M. Tamim, Saad Al-Qahtani, Abdulaziz Al-Dawood, Abdellatif M. Marini, Fatimah H. Al Ehnidi, Shihab Mundekkadan, Amal Matroud, Mohamed S. Mohamed and Saadi Taher

    Citation: Annals of Intensive Care 2017 7:57

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  33. Content type: Research

    Significant effort has been devoted to defining parameters for predicting fluid responsiveness. Our goal was to study the feasibility of predicting fluid responsiveness by transcutaneous partial pressure of ox...

    Authors: Jingyuan Xu, Xiao Peng, Chun Pan, Shixia Cai, Xiwen Zhang, Ming Xue, Yi Yang and Haibo Qiu

    Citation: Annals of Intensive Care 2017 7:56

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  34. Content type: Research article

    Asthma is the most common obstructive airway disease in children and adults. Nasal high flow (NHF) is a recent device that is now used as a primary support for respiratory distress. Several studies have report...

    Authors: Florent Baudin, Alexandra Buisson, Blandine Vanel, Bruno Massenavette, Robin Pouyau and Etienne Javouhey

    Citation: Annals of Intensive Care 2017 7:55

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  35. Content type: Research

    Little is known about the causes, clinical course and long-term outcome of comatose patients with prolonged hypoglycemic encephalopathy.

    Authors: Guillaume Barbara, Bruno Mégarbane, Laurent Argaud, Guillaume Louis, Nicolas Lerolle, Francis Schneider, Stéphane Gaudry, Nicolas Barbarot, Angéline Jamet, Hervé Outin, Sébastien Gibot and Pierre-Edouard Bollaert

    Citation: Annals of Intensive Care 2017 7:54

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  36. Content type: Research

    The performance of severity-of-illness scores varies in different scenarios and must be validated prior of being used in a specific settings and geographic regions. Moreover, models’ calibration may deteriorat...

    Authors: Giulliana Martines Moralez, Ligia Sarmet Cunha Farah Rabello, Thiago Costa Lisboa, Mariza da Fonte Andrade Lima, Rodrigo Marques Hatum, Fernando Vinicius Cesar De Marco, Alessandra Alves, Jorge Eduardo da Silva Soares Pinto, Hélia Beatriz Nunes de Araújo, Grazielle Viana Ramos, Aline Reis Silva, Guilherme Côrtes Fernandes, Guilherme Brenande Alves Faria, Ciro Leite Mendes, Roberto Álvaro Ramos Filho, Valdênia Pereira de Souza…

    Citation: Annals of Intensive Care 2017 7:53

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  37. Content type: Review

    Veno-venous extracorporeal membrane oxygenation (ECMO) for refractory acute respiratory distress syndrome (ARDS) is a rapidly expanding technique. We performed a systematic review and meta-analysis of the most...

    Authors: Sergi Vaquer, Candelaria de Haro, Paula Peruga, Joan Carles Oliva and Antonio Artigas

    Citation: Annals of Intensive Care 2017 7:51

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  38. Content type: Research

    In critically ill patients with permissive hyperglycemia, it is uncertain whether exogenous insulin administration suppresses or enhances c-peptide secretion (a marker of pancreatic beta-cell response). We aim...

    Authors: Marco Crisman, Luca Lucchetta, Nora Luethi, Luca Cioccari, Que Lam, Glenn M. Eastwood, Rinaldo Bellomo and Johan Mårtensson

    Citation: Annals of Intensive Care 2017 7:50

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  39. Content type: Review

    The French Intensive Care Society organized its yearly Paris International Conference in intensive care on June 18–19, 2015. The main purpose of this meeting is to gather the best experts in the field in order...

    Authors: Rinaldo Bellomo, Claudio Ronco, Ravindra L. Mehta, Pierre Asfar, Julie Boisramé-Helms, Michael Darmon, Jean-Luc Diehl, Jacques Duranteau, Eric A. J. Hoste, Joannes-Boyau Olivier, Matthieu Legrand, Nicolas Lerolle, Manu L. N. G. Malbrain, Johan Mårtensson, Heleen M. Oudemans-van Straaten, Jean-Jacques Parienti…

    Citation: Annals of Intensive Care 2017 7:49

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  40. Content type: Research

    Jaundice and cholestatic hepatic dysfunction are frequent findings in critically ill patients associated with increased mortality. Cholestasis in critically ill patients is closely associated with stimulation ...

    Authors: Thomas Horvatits, Andreas Drolz, Karoline Rutter, Kevin Roedl, Lies Langouche, Greet Van den Berghe, Günter Fauler, Brigitte Meyer, Martin Hülsmann, Gottfried Heinz, Michael Trauner and Valentin Fuhrmann

    Citation: Annals of Intensive Care 2017 7:48

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  41. Content type: Research

    Extubation failure is associated with increased morbidity and mortality, but cannot be safely predicted or avoided. High-flow nasal cannula (HFNC) prevents postextubation respiratory failure in low-risk patients.

    Authors: Rafael Fernandez, Carles Subira, Fernando Frutos-Vivar, Gemma Rialp, Cesar Laborda, Joan Ramon Masclans, Amanda Lesmes, Luna Panadero and Gonzalo Hernandez

    Citation: Annals of Intensive Care 2017 7:47

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  42. Content type: Research

    Despite the central role of nurses in intensive care, a relationship between intensive care nurse workload/staffing ratios and survival has not been clearly established. We determined whether there is a thresh...

    Authors: Anna Lee, Yip Sing Leo Cheung, Gavin Matthew Joynt, Czarina Chi Hung Leung, Wai-Tat Wong and Charles David Gomersall

    Citation: Annals of Intensive Care 2017 7:46

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  43. Content type: Research

    Pneumonia is one of the major complications of drowning, but the optimal empirical antibiotic treatment is not clearly defined. Multidrug-resistant (MDR) bacteria and fungi have been identified in a recent se...

    Authors: Alexandre Robert, Pierre-Éric Danin, Hervé Quintard, Nicolas Degand, Nihal Martis, Denis Doyen, Céline Pulcini, Raymond Ruimy, Carole Ichai, Gilles Bernardin and Jean Dellamonica

    Citation: Annals of Intensive Care 2017 7:45

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  44. Content type: Research

    Pre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could ben...

    Authors: Ignacio Martin-Loeches, Arturo Muriel-Bombín, Ricard Ferrer, Antonio Artigas, Jordi Sole-Violan, Leonardo Lorente, David Andaluz-Ojeda, Adriele Prina-Mello, Ruben Herrán-Monge, Borja Suberviola, Ana Rodriguez-Fernandez, Pedro Merino, Ana M. Loza, Pablo Garcia-Olivares, Eduardo Anton, Eduardo Tamayo…

    Citation: Annals of Intensive Care 2017 7:44

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  45. Content type: Editorial

    Protocols can be helpful in specific situations and may have show benefits in clinical trials. So-called evidence based protocols and checklists frequently remind clinicians to do the obvious, but may also co...

    Authors: Armand R. J. Girbes and Paul E. Marik

    Citation: Annals of Intensive Care 2017 7:42

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