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COVID-19 Research Updates

2021

Research
The Ockham’s razor for estimating the needs of ICU beds during a pandemic
Pierre Squara
Annals of Intensive Care 2021 11:94
Published on: 12 June 2021

Research
Protective ventilation and outcomes of critically ill patients with COVID-19: a cohort study
Juliana C. Ferreira, Yeh-Li Ho, et al.
Annals of Intensive Care 2021 11:92
Published on: 7 June 2021

Research
Short-term health-related quality of life, physical function and psychological consequences of severe COVID-19
Luca Carenzo, Alessandro Protti, Francesca Dalla Corte, et al.
Annals of Intensive Care 2021 11:91
Published on: 4 June 2021

Research
Mental health and stress among ICU healthcare professionals in France according to intensity of the COVID-19 epidemic
Alexandra Laurent, Alicia Fournier, Florent Lheureux, et al.
Annals of Intensive Care 2021 11:90
Published on: 4 June 2021
Annals of Intensive Care 2021 11:90

Research
Impact of dexamethasone on the incidence of ventilator-associated pneumonia and blood stream infections in COVID-19 patients requiring invasive mechanical ventilation: a multicenter retrospective study
Ines Gragueb-Chatti, Alexandre Lopez, Dany Hamidi, et al.
Annals of Intensive Care 2021 11:87
Published on: 31 May 2021

Research
Acute kidney injury in SARS-CoV2-related pneumonia ICU patients: a retrospective multicenter study
Guillaume Geri, Michael Darmon, Lara Zafrani, et al.
Annals of Intensive Care 2021 11:86
Published on: 31 May 2021

Research
Infectious events in patients with severe COVID-19: results of a cohort of patients with high prevalence of underlying immune defect
Anastasia Saade, Giulia Moratelli, Guillaume Dumas, et al.
Annals of Intensive Care 2021 11:83
Published on: 25 May 2021

Research
Characteristics, management, and prognosis of elderly patients with COVID-19 admitted in the ICU during the first wave: insights from the COVID-ICU study
Martin Dres, David Hajage, Said Lebbah, et al.
Annals of Intensive Care 2021 11:77
Published on: 14 May 2021

Research
Specific exposure of ICU staff to SARS-CoV-2 seropositivity: a wide seroprevalence study in a French city-center hospital
Emmanuel Vivier, Caroline Pariset, Stephane Rio, et al.
Annals of Intensive Care 2021 11:75
Published on: 13 May 2021

Research
Convalescent plasma therapy and mortality in COVID-19 patients admitted to the ICU: a prospective observational study
Stefan Hatzl, Florian Posch, Nazanin Sareban, et al.
Annals of Intensive Care 2021 11:73
Published on: 12 May 2021

Research
Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort study
Gaetano Scaramuzzo, Lorenzo Gamberini, Tommaso Tonetti, et al.
Annals of Intensive Care 2021 11:63
Published on: 26 April 2021

Research
Inter-hospital transport of critically ill patients to manage the intensive care unit surge during the COVID-19 pandemic in France
Benoit Painvin, Hélène Messet, Maeva Rodriguez, et al.
Annals of Intensive Care 2021 11:54
Published on: 31 March 2021

Research
Clinical performance of lung ultrasound in predicting ARDS morphology
Andrea Costamagna, Emanuele Pivetta, Alberto Goffi, et al.
Annals of Intensive Care 2021 11:51
Published on: 29 March 2021

Research
Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COVID-19 disease severity and indicator of the need for mechanical ventilation, ARDS and mortality
Adeline Lim, Aleksandar Radujkovic, Markus A. Weigand and Uta Merle
Annals of Intensive Care 2021 11:50
Published on: 22 March 2021

Research
Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?
Kevin Roedl, Dominik Jarczak, Andreas Drolz,  et al.
Annals of Intensive Care 2021 11:44
Published on: 15 March 2021

Research
New clinical algorithm including fungal biomarkers to better diagnose probable invasive pulmonary aspergillosis in ICU
Joffrey Hamam, Jean-Christophe Navellou, Anne-Pauline Bellanger, et al.
Annals of Intensive Care 2021 11:41
Published on: 8 March 2021

Research
Continuous positive airway pressure for respiratory support during COVID-19 pandemic: a frugal approach from bench to bedside
Guillaume Carteaux, Manuella Pons, François Morin, et al.
Annals of Intensive Care 2021 11:38
Published on: 2 March 2021

Research
High flow nasal oxygen therapy to avoid invasive mechanical ventilation in SARS-CoV-2 pneumonia: a retrospective study
Nicolas Bonnet, Olivier Martin, Marouane Boubaya, et al.
Annals of Intensive Care 2021 11:37
Published on: 27 February 2021

Review
Intensive care management of patients with COVID-19: a practical approach
Ludhmila Abrahão Hajjar, Isabela Bispo Santos da Silva Costa, Stephanie Itala Rizk, et al.
Annals of Intensive Care 2021 11:36
Published on: 18 February 202

Letter to the Editor
Predicting fluid responsiveness in non-intubated COVID-19 patients: two methods are better than one
Morgan Caplan, Michael Howsam, Raphael Favory & Sebastien Preau
Annals of Intensive Care 2021 11:34
Published on: 15 February 202
A related Letter to the Editor was published in Annals of Intensive Care 2020 11:19
The original article was published in Annals of Intensive Care 2020 10:168

Research
Non-invasive method to detect high respiratory effort and transpulmonary driving pressures in COVID-19 patients during mechanical ventilation
Lisanne Roesthuis, Maarten van den Berg and Hans van der Hoeven
Annals of Intensive Care 2021 11:26
Published on: 8 February 2021

Research
Increased susceptibility to intensive care unit-acquired pneumonia in severe COVID-19 patients: a multicentre retrospective cohort study
Jean-François Llitjos, Swann Bredin, Jean-Baptiste Lascarrou, et al.
Annals of Intensive Care 2021 11:20
Published on: 29 January 2021

Letter to the Editor
Predicting fluid responsiveness in non-intubated COVID-19 patients
Frederic Michard
Annals of Intensive Care 2021 11:19
Published on: 27 January 2021
An Authors' response can be found here
The original article was published in Annals of Intensive Care 2020 10:168

Letter to the Editor
Triage policy of severe Covid-19 patients: what to do now?Pieter Depuydt and Bertrand Guidet
Annals of Intensive Care 2021 11:18
Published on: 27 January 2021
The original article was published in Annals of Intensive Care 2020 10:133

Research
Higher anticoagulation targets and risk of thrombotic events in severe COVID-19 patients: bi-center cohort study
Julie Helms, François Severac, Hamid Merdji, et al.
Annals of Intensive Care 2021 11:14
Published on: 25 January 2021

Research
Elevated plasma IL-6 and CRP levels are associated with adverse clinical outcomes and death in critically ill SARS-CoV-2 patients: inflammatory response of SARS-CoV-2 patients
Jean-Rémi Lavillegrand, Marc Garnier, Agathe Spaeth, et al.
Annals of Intensive Care 2020 11:9
Published on: 13 January 2021

Research
Lung ultrasound score predicts outcomes in COVID-19 patients admitted to the emergency department
Julio Cesar Garcia de Alencar, Julio Flavio Meirelles Marchini, Lucas Oliveira Marino, et al.
Annals of Intensive Care 2020 11:6
Published on: 11 January 2021

Research
Pilot trial of high-dose vitamin C in critically ill COVID-19 patients
Jing Zhang, Xin Rao, Yiming Li, Yuan Zhu, et al.
Annals of Intensive Care 2020 11:5
Published on: 9 January 2021


2020

Research
Characteristics and risk factors associated with critical illness in pediatric COVID-19
Grace Fisler, Stephanie M. Izard, Sareen Shah, et al.
Annals of Intensive Care 2020 10:171
Published on: 19 December 2020

Research
Protracted viral shedding and viral load are associated with ICU mortality in Covid-19 patients with acute respiratory failure
L. Bitker, F. Dhelft, L. Chauvelot, et al.
Annals of Intensive Care 2020 10:167
Published on: 10 December 2020

Research
Reliability and limits of transport-ventilators to safely ventilate severe patients in special surge situations
Dominique Savary, Arnaud Lesimple, François Beloncle, et al.
Annals of Intensive Care 2020 10:166
Published on: 9 December 2020

Letter to the Editor
SORT maneuver: ease and safety for the practitioner and the patient
Mahdi Najafi
Annals of Intensive Care 2020 10:160
Published on: 30 November 2020
The original article was published in Annals of Intensive Care 2020 10:79
Letter to the Editor to this article has been published in Annals of Intensive Care 2020 10:162

Research
Ventilator-associated pneumonia in patients with SARS-CoV-2-associated acute respiratory distress syndrome requiring ECMO: a retrospective cohort study
Charles-Edouard Luyt, Tarek Sahnoun, Melchior Gautier, et al.
Ann Intensive Care 2020 10:158
Published on: 23 November 2020

Letter to the Editor
P-SILI as justification for intubation in COVID-19: readers as arbiters
Martin J. Tobin, Amal Jubran and Franco Laghi
Ann Intensive Care 2020 10:156
Published on: 18 November 2020

Research
Adsorption therapy in critically ill with septic shock and acute kidney injury: a retrospective and prospective cohort study
Gregor A. Schittek, Philipp Zoidl, Michael Eichinger, et al.
Ann Intensive Care 2020 10:154
Published on: 18 November 2020

Research
Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndrome
François Bagate, Samuel Tuffet, Paul Masi,  et al.
Ann Intensive Care 2020 10:151
Published on: 4 November 2020

Letter to the Editor
Comment on “Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study”
Elisa Damiani, Andrea Carsetti, Erika Casarotta, et al.
Ann Intensive Care 2020 10:147
Published on: 23 October 2020
Response Letter by 
Dhiel et al.
Original manuscript: Dhiel et al. 

Research
Biased and unbiased estimation of the average length of stay in intensive care units in the Covid-19 pandemic
Nathanael Lapidus, Xianlong Zhou, Fabrice Carrat, et al.
Ann Intensive Care 2020 10:135
Published on: 16 October 2020

Letter to the Editor
Response to Damiani and colleague
J-L Diehl, N. Peron, A. Philippe and D. M. Smadja
Ann Intensive Care 2020 10:140
Published on: 14 October 2020
This is a response to the Letter of Damiani et al.
Original manuscript: Dhiel et al. 

Letter to the Editor
COVID-19: scientific reasoning, pragmatism and emotional bias
Luciano Gattinoni, John J. Marini, Davide Chiumello, et al.
Ann Intensive Care 2020 10:134
Published on: 12 October 2020
This is a response to the Letter of Tobin et al 
Original manuscript: Gattinoni et al.

Research
Use of critical care resources during the first 2 weeks (February 24–March 8, 2020) of the Covid-19 outbreak in Italy
Tommaso Tonetti, Giacomo Grasselli, Alberto Zanella, et al.
Ann Intensive Care 2020 10:133
Published on: 12 October 2020
Letter to the Editor to this article has been published in Annals of Intensive Care 2021 11:18

Review
Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis
Axel Nierhaus, Giorgio Berlot, Detlef Kindgen-Milles, et al.
Ann Intensive Care 2020 10:132
Published on: 7 October 2020

Research
Characteristics and outcomes of acute respiratory distress syndrome related to COVID-19 in Belgian and French intensive care units according to antiviral strategies: the COVADIS multicentre observational study
David Grimaldi, Nadia Aissaoui, Gauthier Blonz,
Ann Intensive Care 2020 10:131
Published on: 6 October 2020

Letter to the Editor
Transpulmonary pressures in obese and non-obese COVID-19 ARDS
Mehdi Mezidi, Florence Daviet, Paul Chabert, et al.
Ann Intensive Care 2020 10:129
Published on: 1 October 2020

Letter to the Editor
Vitamins as adjunctive treatment for coronavirus disease!
Indu Kapoor, Hemanshu Prabhakar and Charu Mahajan
Ann Intensive Care 2020 10:127
Published on: 29 September 2020

Research
Surgical mask on top of high-flow nasal cannula improves oxygenation in critically ill COVID-19 patients with hypoxemic respiratory failure
Virginie Montiel, Arnaud Robert, Annie Robert, et al.
Ann Intensive Care 2020 10:125
Published on: 29 September 2020

Review
Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review
Yasser Sakr, Manuela Giovini, Marc Leone, et al.
Ann Intensive Care 2020 10:124
Published on: 16 September 2020

Research
Bacterial and viral co-infections in patients with severe SARS-CoV-2 pneumonia admitted to a French ICU
Damien Contou, Aurore Claudinon, Olivier Pajot, et al.
Ann Intensive Care 2020 10:119
Published on: 3 September 2020

Research
Acute kidney injury in patients with SARS-CoV-2 infection
Adrien Joseph, Lara Zafrani, Asma Mabrouki, et al.
Ann Intensive Care 2020 10:117
Published on: 3 September 2020

Research
Symptoms of burnout in intensive care unit specialists facing the COVID-19 outbreak
Elie Azoulay, Jan De Waele, Ricard Ferrer, et al.
Ann Intensive Care 2020 10:110
Published on: 3 August 2020

Letter to the Editor
Is hypoxemia explained by intracardiac or intrapulmonary shunt in COVID-19-related acute respiratory distress syndrome?
Paul Masi, François Bagate, Thomas d’Humières, et al.
Ann Intensive Care 2020 10:108
Published on: 3 August 2020

Letter to the Editor
P-SILI is not justification for intubation of COVID-19 patients
Martin J. Tobin, Franco Laghi and Amal Jubran
Ann Intensive Care 2020 10:105
Published on: 3 August 2020

Research
Clinical outcomes of COVID-19 in Wuhan, China: a large cohort study
Jiao Liu, Sheng Zhang, Zhixiong Wu, et al.
Ann Intensive Care 2020 10:99
Published on: 31 July 2020

Review
SARS-CoV-2 post-infective myocarditis: the tip of COVID-19 immune complications?
Pierre Tissières and Jean-Louis Teboul
Ann Intensive Care 2020 10:98
Published on: 23 July 2020

Research
Respiratory mechanics and gas exchanges in the early course of COVID-19 ARDS: a hypothesis-generating study
J.-L. Diehl, N. Peron, R. Chocron, B. Debuc, et al.
Ann Intensive Care 2020 10:95
Published on: 16 July 2020

Letter to the Editor
Spontaneous breathing, transpulmonary pressure and mathematical trickery
Luciano Gattinoni, John J. Marini, Mattia Busana, et al.
Ann Intensive Care 2020 10:88
Published on: 8 July 2020

Review
Ethical dilemmas due to the Covid-19 pandemic
René Robert, Nancy Kentish-Barnes, Alexandre Boyer, et al.
Ann Intensive Care 2020 10:84
Published on: 17 June 2020

Review
Caution about early intubation and mechanical ventilation in COVID-19
Martin J. Tobin, Franco Laghi and Amal Jubran
Ann Intensive Care 2020 10:78
Published on: 9 June 2020

Review
Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China
You Shang, Chun Pan, Xianghong Yang, et al.
Ann Intensive Care 2020 10:73
Published on: 6 June 2020

Letter to the Editor
COVID-19-associated invasive pulmonary aspergillosis
Lynn Rutsaert, Nicky Steinfort, Tine Van Hunsel, et al.
Ann Intensive Care 2020 10:69
Published on: 1 June 2020

Research
Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children
Marion Grimaud, Julie Starck, Michael Levy, et al.
Ann Intensive Care 2020 10:69
Published on: 1 June 2020

Letter to the Editor
Lack of viral clearance by the combination of hydroxychloroquine and azithromycin or lopinavir and ritonavir in SARS-CoV-2-related acute respiratory distress syndrome
Sami Hraiech, Jérémy Bourenne, Khaldoun Kuteifan, et al.
Ann Intensive Care 2020 10:63
Published on: 24 May 2020

Letter to the Editor
Nitric oxide inhalation as an interventional rescue therapy for COVID-19-induced acute respiratory distress syndrome
Jun Kobayashi and Isamu Murata
Ann Intensive Care 2020 10:61
Published on: 20 May 2020

Letter to the Editor
Microvascular alterations in patients with SARS-COV-2 severe pneumonia
Elisa Damiani, Andrea Carsetti, Erika Casarotta, et al.
Ann Intensive Care 2020 10:60
Published on: 20 May 2020

Letter to the Editor
The outbreak of COVID-19 in Mulhouse
Khaldoun Kuteifan, Pierre Pasquier, Christian Meyer, et al.
Ann Intensive Care 2020 10:59
Published on: 19 May 2020

Research
Recruitability and effect of PEEP in SARS-Cov-2-associated acute respiratory distress syndrome
François M. Beloncle, Bertrand Pavlovsky, Christophe Desprez, et al.
Ann Intensive Care 2020 10:55
Published on: 12 May 2020

Review
Therapeutic strategies for critically ill patients with COVID-19
Lei Li, Ranran Li, Zhixiong Wu, Xianghong Yang, et al.
Ann Intensive Care 2020 10:45
Published on: 20 April 2020

Letter to the Editor
Critically ill SARS-CoV-2-infected patients are not stratified as sepsis by the qSOFA
Marion Ferreira, Timothee Blin, Nived Collercandy, et al.
Ann Intensive Care 2020 10:43
Published on: 19 April 2020

Letter to the Editor
Lower mortality of COVID-19 by early recognition and intervention: experience from Jiangsu Province
Qin Sun, Haibo Qiu, Mao Huang and Yi Yang
Ann Intensive Care 2020 10:33
Published on: 18 March 2020