- Open Access
New-onset supraventricular arrhythmia during septic shock: prevalence, risk factors and prognosis
© Seemann et al. 2015
Received: 17 July 2015
Accepted: 13 September 2015
Published: 22 September 2015
The aims of this study were to prospectively assess the prevalence of sustained (lasting more than 30 s) new-onset supraventricular arrhythmia (NOSVA) during septic shock, identify the associated factors (including septic myocardial dysfunction), and evaluate its impact on hemodynamics and prognosis.
Patients with a diagnosis of septic shock were screened in a medical intensive care unit of a tertiary hospital center in France with a continuous 12-lead EKG for the occurrence of NOSVA. Biological and clinical data (including septic myocardial dysfunction characterized by echocardiography) were collected. We also assessed the hemodynamic tolerance and prognosis of NOSVA.
Among the 71 septic shock episodes assessed during the study, NOSVA occurred in 30 [prevalence of 42 %, 95 % confidence interval (CI) 30–53 %]. Among all recorded factors, only renal failure (as assessed by renal SOFA score at day 1) was associated with NOSVA and this difference persisted by multivariable analysis (odds ratio of 1.29, 95 % CI 1.03–1.62, p = 0.03). There was a significant increase in norepinephrine dosage during the first hour after SVA onset. NOSVA was associated with longer catecholamine use during septic shock as compared with patients in sinus rhythm, whereas ICU mortality was identical between groups.
We found a high prevalence of sustained NOSVA during septic shock. NOSVA was not related to septic myocardial dysfunction, but rather to acute renal failure, raising the hypothesis of an acute renocardiac syndrome.
Supraventricular arrhythmia (SVA) is the most common cardiac rhythm disturbance occurring in intensive care unit (ICU) patients . Sepsis is frequently associated with new-onset SVA (NOSVA), which has been reported in 6 % of patients with severe sepsis  and in 46 % of those with septic shock . Data evaluating risk factors for NOSVA during septic shock are scarce [2, 4].
Septic myocardial dysfunction is characterized by an acute, reversible depression of left ventricle (LV) contractility with normal or low filling pressures . Its mechanisms are not fully understood, though circulating cytokines or cellular respiration alteration resulting from mitochondrial dysfunction may play a crucial role . Septic cardiomyopathy may also involve diastolic dysfunction  and right ventricle dysfunction . Whether septic cardiomyopathy may constitute an arrythmogenic condition is unknown to date. In addition, whether inotropic drugs used to correct LV systolic dysfunction in septic shock patients  may increase the risk of NOSVA remains unclear.
SVA has been associated with increased morbidity related to circulatory compromise, cardio-embolic events or hemorrhagic complications of anticoagulant treatments. Little is known about the prognostic impact of NOSVA in the context of septic shock .
The aim of our study was to prospectively assess the prevalence of NOSVA during septic shock, to identify the associated factors (including the role of septic myocardial dysfunction), and to evaluate its impact on hemodynamics and outcome of patients.
Patients and methods
Patients who met septic shock criteria (as defined according to the ACCP/SCCM Consensus Conference ) were prospectively included at the medical ICU of Henri Mondor University Hospital (Créteil, France) between October 2011 and December 2012. Non-inclusion criteria were cardiac surgery within the preceding month, chronic heart failure (defined by a baseline left ventricular ejection fraction below 45 %) or a history of persistent SVA. The study was approved by the institutional ethics committee (Comité de Protection de Personnes Ile de France IX) as a component of standard care and patient’s consent was waived. Written and oral information about the study was given to the families. Patient’s severity was evaluated by the McCabe and Jackson score for underlying diseases , the SAPS II score for acute illness at ICU admission  and the SOFA (sequential organ failure assessment) score for organ dysfunction during septic shock . Chronic renal failure was defined as a glomerular filtration rate below 30 ml/min/1.73 m2 according to MDRD formula . Acute renal failure and other organ failures were defined using the SOFA score . Acute respiratory distress syndrome (ARDS) was defined according to the Berlin criteria . Blood concentration of thyroid stimulating hormone, NT-pro BNP and cardiac troponin T were assessed using an immuno-assay on a COBAS 6000 analyzer (Roche Diagnostics, Boulogne-Billancourt, France). Follow-up for the study was at least until ICU discharge.
All patients were continuously monitored with a reconstructed 12-lead EKG (using a continuous 6-lead cardiac monitoring, Dräger Infinity® Acute Care System, Antony, France). EKG data were automatically recorded, digitally stored and checked daily for occurrence of NOSVA during the entire course of septic shock. SVA episodes lasting more than 30 s were assessed by two cardiologists (any discrepancy being solved by consensus) and classified as atrial fibrillation, atrial flutter or atypical flutter, using standard definitions .
Septic myocardial dysfunction
To evaluate cardiac function, we used transthoracic echocardiography (TTE) or multiplane transesophageal echocardiography (TEE), when TTE did not allow accurate measurements because of poor acoustic windows. Echocardiograms were performed by trained operators (competence in advanced critical care echocardiography)  using an iE33 system (Philips Ultrasound, Bothell, WA, USA) with a standard procedure . Briefly, the following echocardiographic views were examined: four-chamber and two-chamber long-axis views to assess left ventricle (LV) ejection fraction (computed from LV volumes using the bi-plane Simpson method  when image quality was good, or visually estimated when poor image quality did not allow sufficient identification of the endocardium ), right and left atrium size , right ventricle size (a dilated RV was defined by an end-diastolic RV/LV area ratio >0.6) ), right ventricle function (using the tricuspid annular plane systolic excursion and tissue Doppler peak systolic wave at the tricuspid valve annulus ); long-axis M-mode view of the superior (TEE) or inferior (TTE) vena cava to assess their respiratory variability ; and the presence of pericardial effusion. Pulsed-wave Doppler aortic flow was obtained at the level of the aortic annulus and the velocity–time integral was automatically processed by tracing the envelope of aortic flow for cardiac index calculation. Echocardiographic images were digitally stored, and a computer-assisted evaluation was performed off-line by two trained operators. Septic cardiac dysfunction was defined as an LVEF <45 % or the need for an inotrope infusion in order to achieve an LVEF ≥45 %.
The data were analyzed using SPSS Base 13.0 (SPSS Inc, Chicago, IL, USA) and R 2.15.2 (The R Foundation for Statistical Computing, Vienna, Austria) statistical software packages. Continuous data were expressed as median [25th–75th percentiles], unless otherwise specified and were compared using the Mann–Whitney test for independent samples and the Friedman test for related samples. Categorical variables, expressed as percentages, were evaluated using the Chi-square test or Fisher exact test. To evaluate independent factors associated with NOSVA (time-dependent variable), significant or marginally significant univariate risk factors (p < 0.10) recorded prior or at the time of the first episode of NOSVA, were examined using backward stepwise multivariate Cox proportional-hazards regression model; septic myocardial dysfunction and patient severity as assessed by SAPS II score at ICU admission were also included in the model; thus, the five variables included in the model were SAPS II score at ICU admission, age, septic myocardial dysfunction, renal and non-renal SOFA scores at day 1 of septic shock. Coefficients were computed by the method of maximum likelihood. Two-tailed p values lower than 0.05 were considered significant.
Patients’ characteristics and NOSVA
Patients’ baseline characteristics, according to the occurrence of new-onset supraventricular arrhythmia during at least one septic shock episode
NOSVA during septic shock episode
Never (n = 38)
Ever (n = 27)
History of cardiac disease
Coronary artery disease
Valvular heart disease
PM or ICD
Chronic renal failure
History of stroke
History of thyroid dysfunction
History of dyslipidemia
History of hypertension
SAPS II score at ICU admission
Factors associated with NOSVA occurrence
Organ dysfunction, biological data and treatments during septic shock according to supraventricular arrhythmia occurrence
Sinus rhythm (n = 41)
SVA (n = 30)
SOFA day 1
Day 1 blood gases
Thyroid stimulating hormone, µUI/L
Cardiac Troponin peak between day 1 and day 3, ng/L
NT proBNP peak between day 1 and day 3, pg/mL
Minimal potassium level during septic shock, mmol/L
Maximal potassium level during septic shock, mmol/L
Cumulative fluid balance during shock, mL
Daily fluid balance during shock, mL/day
Dobutamine use during shock
Dobutamine maximal dose, µg/kg/mina
Dobutamine maximal dose, µg/kg/min, mean (SD)a
Norepinephrine use during shock
Norepinephrine maximal dose, mg/ha
Norepinephrine maximal dose, mg/h, mean (SD)a
Epinephrine use during shock
Dual catecholamine use during shock
Length of catecholamine use during shock, days
Length of vasopressor use during shock, days
Invasive mechanical ventilation
Moderate to severe ARDS
Dialysis during shock
Steroid use during shock
Steroid use before SVA onset
Superior vena cava central line in place during shock
Body temperature and biological variables stratified according to their reference limits, at time of first occurrence of supraventricular arrhythmia during septic shock
SVA (n = 30)
Temperature >38.3 °C
Temperature <36.0 °C
Potassium level, mmol/L
Potassium level <3.5 mmol/L
Potassium level >5 mmol/L
Glycemia <4 mmol/L
Glycemia >10 mmol/L
PaO2 <60 mmHg
1 (3.1 %)
Serum creatinine, µmol/L
Serum creatinine >130 µmol/L
Serum urea, mmol/L
Serum urea >7 mmol/L
Echocardiographic data during septic shock
Sinus rhythm (n = 41)
SVA (n = 30)
Echocardiogram on sinus rhythm
Echocardiogram under inotropes
Septic myocardial dysfunction (n = 69)b
Cardiac index, L/min/m2
RA size, cm2
LA size, cm2
Tricuspid tissue Doppler s’ wave, cm/s
Factors associated with new-onset supraventricular arrhythmia occurrence by Cox analysis
Hazard ratio (95 % CI), p value
SAPS II score at ICU admission
1.02 (1.00–1.03), p = 0.05
1.02 (0.99–1.05), p = 0.23
Septic myocardial dysfunction
1.40 (0.68–2.92), p = 0.36
1.28 (1.02–1.60), p = 0.03
1.29 (1.03 1.62), p = 0.03
0.99 (0.90–1.11), p = 0.97
Treatment of NOSVA
A treatment for cardioversion was administered in 21 of 30 episodes of NOSVA, including magnesium sulfate (n = 6), amiodarone (n = 19), and/or electric shock (n = 3). Cardioversion was effective in 18 (86 %) cases. Curative anticoagulant treatment with heparin was used in eight (27 %) patients with NOSVA; in the other cases, the attending physician considered that the benefit/risk ratio of curative anticoagulation was unfavorable. No stroke was diagnosed among patients with NOSVA up to ICU discharge.
Outcome of NOSVA
Hemodynamic data immediately before and during the first hour of the first episode of supraventricular arrhythmia
Before SVA onset (n = 30)
After SVA onset (n = 30)
Systolic arterial pressure, mmHg
Diastolic arterial pressure, mmHg
Mean arterial pressure, mmHg
Arterial pulse pressure, mmHg
Heart rate, beats/min
Dobutamine dose, µg/kg/mina
Norepinephrine dose, mg/ha
Epinephrine dose, mg/ha
When repeating the analyses while considering only the first episode of septic shock in patients with multiple episodes, we found concordant results: (1) in the Cox proportional-hazards regression analysis, the only factor associated with NOSVA was the renal SOFA score at day 1 of septic shock [hazard ratio of 1.26 (95 % CI 0.99–1.60), with a marginally significant p value (p = 0.06]; (2) NOSVA was associated with longer catecholamine use (4 [3–7] vs. 3 [2–6], p = 0.049), and vasopressor use (4 [3–7] vs. 3 [2–5], p = 0.03) during septic shock, and a trend towards longer ICU length of stay in survivors (16.0 [10.0–32.0] days vs. 8.5 [4.0–24.0] days, p = 0.067).
We report a high prevalence of NOSVA (42 %; 95 % CI [30–54 %]) during septic shock. NOSVA was not associated with septic myocardial dysfunction, but with renal failure by multivariable analysis. Patients with NOSVA exhibited longer durations of shock and a trend towards longer ICU stay.
The prevalence of NOSVA in our study is higher than reported in the general ICU population [1, 2, 23], but comparable to the 46 % atrial fibrillation rate reported by Meierhenrich et al.  in a cohort of patients with septic shock. The higher prevalence of SVA in septic shock patients might be related to their higher severity of illness. The use of inotropes in septic shock patients is unlikely to fully explain such a difference, since many of our patients presented NOSVA before initiating catecholamine support.
We were unable to demonstrate an association between the occurrence of NOSVA and septic myocardial dysfunction, as assessed by LVEF. Several explanations are possible. First, LVEF may not be the ideal criterion to assess septic cardiomyopathy, notably because of its load-dependency. However, evaluation of cardiac function in our patients was done after fluid loading and while receiving vasoconstrictors. Whether echocardiographic parameters less dependent on afterload, such as speckle tracking derived strain-rate, may better characterize septic cardiomyopathy warrants further research. Second, the mechanisms of septic myocardial dysfunction and substrates/triggers of SVA may differ. Septic cardiomyopathy mainly affects heart ventricles, with depressed contractility and low or normal filling pressures , whereas SVA is an atrial disorder that is mainly influenced by atrial pressure and autonomous nervous system tone. Cardiac biomarkers (B-type natriuretic peptides and troponins), which are mainly released from the ventricular myocytes and mostly influenced by left ventricle function and mass, were not significantly associated with SVA in our series despite a trend towards higher values in the NOSVA group.
We found an association between NOSVA and renal failure by univariate and multivariable analysis. Patients with NOSVA exhibited higher values of serum urea and creatinine, and a higher renal SOFA score as compared to patients in sinus rhythm, whereas the prevalence of chronic renal failure and chronic dialysis was similar between groups. Cardiorenal syndrome (CRS) is a complex pathophysiological disorder of the heart and kidneys in which acute or chronic dysfunction in one organ may induce acute or chronic dysfunction in the other organ . The association we observed between acute renal failure and NOSVA may correspond to either a type 1 CRS (acute cardiorenal syndrome, i.e., an acute deterioration in cardiac function that leads to acute kidney injury), a type 3 CRS (acute renocardiac syndrome, i.e., an acute kidney injury that leads to acute cardiac injury), or a type 5 CRS (secondary cardiorenal syndrome, i.e., a systemic disorder causing cardiac and renal dysfunction) [25, 26]. Hemodynamic alteration during SVA episodes might have impeded renal perfusion, thus leading to an acute cardiorenal syndrome. However, the renal SOFA score was significantly different between the NOSVA group and the sinus rhythm group from the very start of septic shock (day 1), favoring the hypothesis of an acute renocardiac syndrome. The mechanisms underlying acute renocardiac syndrome are not clearly understood, but may involve direct (e.g., cytokines, sympathetic tonus and renin–angiotensin–aldosterone system) or indirect (e.g., fluid and electrolyte imbalances) effects of acute kidney injury on the heart [27, 28]. However, in our study, the potential role of dyskalemia and fluid balance on the occurrence of NOSVA did not seem pivotal. Further studies are needed to better scrutinize the spectrum of acute renocardiac syndrome in septic shock patients.
As expected, the occurrence of NOSVA during septic shock was associated with a poor acute hemodynamic tolerance, with a fall in arterial pressure and increased doses of catecholamines. Indeed, the loss of auricular systole and tachycardia-related shortening of ventricular diastole may both contribute to ventricular filling impairment. NOSVA was also associated with longer use of drugs and vasopressors, and a trend towards longer ICU stay. Whether NOSVA is a direct cause of prolonged catecholamine use and longer ICU stay or merely an indicator of severity of illness remains to be determined. The absence of clinical ischemic stroke in our study despite a low curative anticoagulation rate underscores the need to weight the benefit/risk ratio of this treatment for each patient with NOSVA in the ICU setting.
Our study has several limitations. First, the study power was limited by the inclusion of only 71 episodes of septic shock. We cannot formally exclude a possible relationship between septic myocardial dysfunction and NOSVA in a larger sample size. In view of the 30 events observed, we did not strictly follow the classical rule of a minimum of 10 outcome events per predictor variable in the multivariable analysis , but our analysis fulfilled the minimum of 5 events per predictor variable proposed by recent simulation studies . Second, we included some patients with multiple septic shock episodes (more than 1 week apart). Our sensitivity analysis considering only the first episode yielded nearly similar results despite a reduced power. However, we cannot exclude a role for personal susceptibility in the occurrence of NOSVA. Third, we could not perform consecutive echocardiograms during sinus rhythm and at the onset of SVA to better scrutinize hemodynamic changes induced by SVA.
In conclusion, our study showed that sustained NOSVA is frequent during septic shock, poorly tolerated, and is associated with longer catecholamine use. Renal failure, but not myocardial dysfunction, was significantly associated with occurrence of NOSVA during septic shock, raising the hypothesis of an acute renocardiac syndrome.
AS, AMD and CBB designed the study, interpreted the data and drafted the manuscript. AS, FB, KR, GC, and NdP collected and interpreted data. All authors read and approved the final manuscript.
Compliance with ethical guidelines
Competing interests The authors declare that they have no competing interests.
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