All authors participated in the initial PlasmaTV study. OK and SL designed this ancillary study. OK, AD, and SL analyzed the data. OK and SL drafted the manuscript, and all authors participated in the final version of the manuscript. All authors read and approved the final manuscript.
Acknowledgements
We would like to thank all of the PlasmaTV investigators for their tremendous work. We would also like to thank the Plateforme de Recherche Clinique of the Department of Pediatrics, Geneva University Hospital, for their help with this study.
Competing interests
Dr. Spinella reports personal fees from Octapharma and personal fees from Entegrion. The authors declare that they have no competing interests.
Availability of data and materials
Due to regulations in some countries, we are unfortunately not authorized to provide the dataset.
Ethics approval and consent to participate
The primary submission was approved by the Commission Cantonale d’Ethique de la Recherche (protocol GE 13-206). Ethics committees or boards at all 101 sites then individually approve this study.
Funding
This study was funded by the Groupe Francophone de Réanimation et Urgences Pédiatriques (GFRUP) and the Marisa Sophie Research Foundation for Critically Ill Children.
PlasmaTV investigators
Australia: Warwick Butt, Carmel Delzoppo, Kym Bain (Royal Children’s Hospital, Melbourne); Simon Erickson, Nathan Smalley (Princess Margaret Hospital for Children, Perth; Tavey Dorofaeff, Debbie Long (Royal Children’s Hospital, Brisbane); Nathan Smalley, Greg Wiseman (Townsville Hospital, Townsville). Belgium: Stéphan Clénent de Cléty, Caroline Berghe (Cliniquesuniversitaires Saint-Luc, Brussels); Annick de Jaeger (Princess Elisabeth Children’s University Hospital, Ghent); Pierre Demaret, Marc Trippaerts (CHC-CHR, Liège); Ariane Willems, ShancyRooze (Hôpitaluniversitaire des enfantsReine Fabiola, Brussels); Jozef De Dooy (Antwerp University Hospital, Edegem). Canada: Elaine Gilfoyle, Lynette Wohlgemuth (Alberta Children’s Hospital, Calgary, AB); Marisa Tucci, Mariana Dumitrascu (CHU Sainte-Justine, Montréal, QC); Davinia Withington, Julia Hickey (Montreal Children’s Hospital, Montreal, QC); Karen Choong, Lois Sanders (McMaster Children’s Hospital, Hamilton, ON); Gavin Morrison (IWK Health Centre, Halifax, NS); Janice Tijssen (Children’s Hospital, London Health Sciences Centre, London, ON); David Wensley, Gordon Krahn (British Columbia Children’s Hospital, Vancouver, BC); Marc-Andre Dugas, Louise Gosselin (Centre Mère Enfant Soleil, CHU de Québec, Québec, QC); Miriam Santschi (CHUS, Sherbrooke, QC). Chile: Bettina Von Dessauer, Nadia Ordenes (Hospital De Niños Roberto Del Río, Santiago). Denmark: Arash Afshari, Lasse Hoegh Andersen, Jens Christian Nilsson, Mathias Johansen, Anne-Mette Baek Jensen (Rigshospitalet, University of Copenhagen, Copenhagen). Ecuador: Santiago Campos Mino, Michelle Grunauer (Hospital de los Valles, Universidad San Francisco de Quito, Quito. France: Nicolas Joram (Hôpital mère enfant, Nantes); Nicolas Roullet-Renoleau (Hôpital Gatien de Clocheville, CHU Tours, Tours); Etienne Javouhey, Fleur Cour-Andlauer, Aurélie Portefaix (Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon); Olivier Brissaud, Julie Guichoux (Hôpital des Enfants, Bordeaux); Valérie Payen (CHU Grenoble, Grenoble); Pierre-Louis Léger (Hôpital Armand-Trousseau, Paris); Mickael Afanetti (Hopitaux Pédiatriques CHU Lenval, Nice); Guillaume Mortamet (Hopital Necker, Paris); Matthieu Maria (Hôpital d’Enfants CHRU de Nancy, Nancy); Audrey Breining (Hopitaux Universitaires de Strasbourg, Strasbourg); Pierre Tissieres (Hôpital Kremlin-Bicêtre, Paris); Aimée Dorkenoo (CHU Lille, Lille); Anna Deho (Hopital Robert Debré, Paris). Germany: Harry Steinherr (MedizinischeHochschule Hannover, Hannover). Greece: Filippia Nikolaou (Athens Children Hospital P&A Kyriakou, Athens). Italy: Anna Camporesi (Children Hospital VittoreBuzzi, Milano); Federica Mario (Department of Women’s and Children’s Health, Padua). Japan: Tatsuya Kawasaki, Shinya Miura (Shizuoka Children’s Hospital, Shizuoka City). New Zealand: John Beca, Miriam Rea, Claire Sherring, Tracey Bushell (Starship Children’s Hospital, Auckland). Norway: Gunnar Bentsen (Oslo University Hospital—Rikshospitalet, Oslo). Portugal: Alexandra Dinis (Hospital Pediátrico—CHUC, Coimbra); Gabriela Pereira (UCIP Hospital Dona Estefânia, Lisbon); Marisa Vieira (Hospital de Santa Maria, Lisbon); Marta Moniz (Hospital Prof. Dr Fernando Fonseca, Amadora). Saudi Arabia: Saleh Alshehri (King Saud Medical City, Riyadh); Manal Alasnag, Ahmad Rajab (King Fahd Armed Forces Hospital, Jeddah). Slovakia: Maria Pisarcikova (DFN Kosice, Kosice). Spain: Iolanda Jordan (Hospital Sant Joan de Déu, Barcelona); Joan Balcells (Hospital Valld’Hebron, Barcelona); Antonio Perez-Ferrer, Jesús de Vicente Sánchez, Marta Vazquez Moyano (La Paz University Hospital, Madrid); Antonio Morales Martinez (Malaga Regional University Hospital, Malaga); Jesus Lopez-Herce, Maria Jose Solana (Hospital General Universitario Gregorio Marañón, Madrid); Jose Carlos Flores González (Puerta del Mar University Hospital, Cadiz); Maria Teresa Alonso (Hospital Virgen del Rocío, Sevilla); Manuel Nieto Faza (Hospital Universitario Cruces, Bilbao). Switzerland: Marie-Hélène Perez, Vivianne Amiet (CHUV, Lausanne); Carsten Doell (Kinderspital Zürich, Zürich); Alice Bordessoule (Geneva University Hospital, Geneva). The Netherlands: Suzan Cochius-den Otter, Berber Kapitein (Erasmus MC—Sophia Children’s Hospital, Rotterdam); Martin Kneyber (Beatrix Children’s Hospital, Groningen). United Kingdom: Joe Brierley, Vanessa Rea, Stephen McKeever (Great Ormond Street, London); Andrea Kelleher (Royal Brompton Hospital, London); Barney Scholefield, Anke Top, Nicola Kelly, SatnamVirdee (Birmingham Children’s Hospital, Birmingham); Peter Davis, Susan George (Bristol Royal Hospital for Children, Bristol); Kay C. Hawkins, Katie McCall, Victoria Brown (Royal Manchester Children’s Hospital, Manchester); Kim Sykes (University Hospital Southampton, Southampton); Richard Levin, Isobel MacLeod (Yorkhill Children’s Hospital, Glasgow); Marie Horan, PetrJirasek (Alder Hey Children’s hospital, Liverpool); David Inwald, Amina Abdulla, Sophie Raghunanan (Imperial College Healthcare, London); Bob Taylor (Royal Belfast Hospital for Sick Children, Belfast); Alison Shefler, Hannah Sparkes (Oxford University Hospitals, Oxford). USA: Sheila Hanson, Katherine Woods, David Triscari, Kathy Murkowski (Children’s Hospital of Wisconsin, Milwaukee, WI); Caroline Ozment (Duke University, Durham, NC); Marie Steiner, Dan Nerheim, Amanda Galster (University of Minneapolis, Minneapolis, MN); Renee Higgerson, LeeAnn Christie (Dell Children’s Medical Center, Austin, TX); Philip C. Spinella, Daniel Martin, Liz Rourke (Washington University in St. Louis, Saint Louis, MO); Jennifer Muszynski, Lisa Steele, (Nationwide Children’s Hospital, Columbus, OH); Samuel Ajizian, Michael C. McCrory (Wake Forest School of Medicine, Winston-Salem, NC); Kevin O’Brien, Christopher Babbitt, Erin Felkel, Glenn Levine (Miller Children’s Hospital Long Beach, Long Beach, CA); Edward J. Truemper, Machelle Zink (Children’s Hospital and Medical Center, Omaha, NE); Marianne Nellis (NYPH—Weill Cornell Medical College, New York, NY); Neal J. Thomas, Debbie Spear (Penn State Hershey Children’s Hospital, Hershey, PA); Barry Markovitz, Jeff Terry, Rica Morzov (Children’s Hospital Los Angeles, Los Angeles, CA); Vicki Montgomery, Andrew Michael, Melissa Thomas (University of Louisville and Kosair Children’s Hospital, Louisville, KY); Marcy Singleton, Dean Jarvis, Sholeen Nett (Dartmouth Hitchcock Medical Center, Lebanon, NH); Douglas Willson, Michelle Hoot (Virginia Commonwealth University, Richmond, VA); Melania Bembea, Alvin Yiu (Johns Hopkins University, Baltimore, MD); David McKinley, Elizabeth Scarlett, Jennifer Sankey, Minal Parikh (Geisinger, Danville, PA); E. Vincent S. Faustino (Yale School of Medicine, New Haven, CT); Kelly Michelson, Jay Rilinger, Laura Campbell (Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL); Shira Gertz (Hackensack University Medical Center, Hackensack, NJ); Jill M. Cholette (University of Rochester, Rochester, NY); Asumthia Jeyapalan (Holtz Children’s Hospital-Jackson Memorial Hospital, Miami, FL); Margaret Parker (Stony Brook University, Stony Brook, NY); Scot Bateman, Amanda Johnson (UMass Memorial Children’s Medical Center, Worcester, MA).